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    Adra2c adrenoceptor alpha 2C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24175, updated on 18-Sep-2018

    Summary

    Official Symbol
    Adra2cprovided by RGD
    Official Full Name
    adrenoceptor alpha 2Cprovided by RGD
    Primary source
    RGD:2058
    See related
    Ensembl:ENSRNOG00000009299
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Orthologs

    Genomic context

    See Adra2c in Genome Data Viewer
    Location:
    14q21
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (80730307..80732010, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 14 NC_005113.3 (81422130..81423833, complement)

    Chromosome 14 - NC_005113.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100912062 Neighboring gene smoothelin-like Neighboring gene uncharacterized LOC108352779 Neighboring gene mCG20085-like Neighboring gene LDL receptor related protein associated protein 1

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    G protein-coupled receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    adrenergic receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    alpha-2A adrenergic receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    alpha-2A adrenergic receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    alpha2-adrenergic receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    alpha2-adrenergic receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    epinephrine binding IEA
    Inferred from Electronic Annotation
    more info
     
    epinephrine binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    activation of protein kinase B activity IEA
    Inferred from Electronic Annotation
    more info
     
    activation of protein kinase B activity ISO
    Inferred from Sequence Orthology
    more info
     
    adenylate cyclase-activating adrenergic receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    adrenergic receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    female pregnancy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of uterine smooth muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    platelet activation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of vasoconstriction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    receptor transactivation IEA
    Inferred from Electronic Annotation
    more info
     
    receptor transactivation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of sensory perception of pain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    axon terminus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    glutamatergic synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of postsynaptic density membrane EXP
    Inferred from Experiment
    more info
    PubMed 
    integral component of postsynaptic density membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    alpha-2C adrenergic receptor
    Names
    Adrenergic alpha2C- receptor class I
    Adrenergic, alpha2C-, receptor class I
    adrenergic receptor, alpha 2c
    adrenergic, alpha-2C-, receptor
    alpha-2 adrenergic receptor subtype C4
    alpha-2C adrenoceptor
    alpha-2C adrenoreceptor
    alpha-2CAR

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138506.1NP_612515.1  alpha-2C adrenergic receptor

      See identical proteins and their annotated locations for NP_612515.1

      Status: PROVISIONAL

      Source sequence(s)
      M58316
      UniProtKB/Swiss-Prot
      P22086
      Related
      ENSRNOP00000012322.1, ENSRNOT00000012322.3
      Conserved Domains (2) summary
      pfam00001
      Location:68433
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:60194
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005113.4 Reference Rnor_6.0 Primary Assembly

      Range
      80730307..80732010 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000082.1 Alternate Rn_Celera

      Range
      74399360..74401063 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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