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    Pou3f3 POU class 3 homeobox 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 192109, updated on 21-Jul-2018

    Summary

    Official Symbol
    Pou3f3provided by RGD
    Official Full Name
    POU class 3 homeobox 3provided by RGD
    Primary source
    RGD:619768
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Brn1; RHS1
    Summary
    acts as a transcriptional activator in oligodendrocytes; may play a role in regulation of neural development [RGD, Feb 2006]
    Annotation information
    Annotation category: partial on reference assembly
    Expression
    Biased expression in Kidney (RPKM 166.4) and Brain (RPKM 66.4) See more
    Orthologs

    Genomic context

    See Pou3f3 in Genome Data Viewer
    Location:
    9q22
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (49479148..49482246)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 9 NC_005108.3 (49152036..49154632)

    Chromosome 9 - NC_005108.4Genomic Context describing neighboring genes Neighboring gene similar to 60S ribosomal protein L35 Neighboring gene POU3F3 adjacent non-coding transcript 1 Neighboring gene uncharacterized LOC103690527 Neighboring gene uncharacterized LOC102547455 Neighboring gene uncharacterized LOC103690528

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    HMG box domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    HMG box domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    brain development IEA
    Inferred from Electronic Annotation
    more info
     
    cerebral cortex radially oriented cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    cerebral cortex radially oriented cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    chemical homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    chemical homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    excretion IEA
    Inferred from Electronic Annotation
    more info
     
    excretion ISO
    Inferred from Sequence Orthology
    more info
     
    forebrain ventricular zone progenitor cell division IEA
    Inferred from Electronic Annotation
    more info
     
    forebrain ventricular zone progenitor cell division ISO
    Inferred from Sequence Orthology
    more info
     
    kidney development ISO
    Inferred from Sequence Orthology
    more info
     
    metanephric DCT cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    metanephric DCT cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    metanephric DCT cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    metanephric ascending thin limb development IEA
    Inferred from Electronic Annotation
    more info
     
    metanephric ascending thin limb development ISO
    Inferred from Sequence Orthology
    more info
     
    metanephric ascending thin limb development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    metanephric loop of Henle development ISO
    Inferred from Sequence Orthology
    more info
     
    metanephric loop of Henle development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    metanephric macula densa development IEA
    Inferred from Electronic Annotation
    more info
     
    metanephric macula densa development ISO
    Inferred from Sequence Orthology
    more info
     
    metanephric macula densa development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    metanephric thick ascending limb development IEA
    Inferred from Electronic Annotation
    more info
     
    metanephric thick ascending limb development ISO
    Inferred from Sequence Orthology
    more info
     
    metanephric thick ascending limb development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    POU domain, class 3, transcription factor 3
    Names
    brain-1
    brain-specific homeobox/POU domain protein 1
    brn-1 protein
    class III POU protein POU-domain

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138837.1NP_620192.1  POU domain, class 3, transcription factor 3

      See identical proteins and their annotated locations for NP_620192.1

      Status: PROVISIONAL

      Source sequence(s)
      AJ001641
      UniProtKB/Swiss-Prot
      Q63262
      Conserved Domains (2) summary
      smart00352
      Location:311385
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:406459
      Homeobox; Homeobox domain

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005108.4 Reference Rnor_6.0 Primary Assembly

      Range
      49479148..49482246
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000077.1 Alternate Rn_Celera

      Range
      42631024..42668104
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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