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    Hmgcs2 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 [ Mus musculus (house mouse) ]

    Gene ID: 15360, updated on 2-Oct-2018

    Summary

    Official Symbol
    Hmgcs2provided by MGI
    Official Full Name
    3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2provided by MGI
    Primary source
    MGI:MGI:101939
    See related
    Ensembl:ENSMUSG00000027875 Vega:OTTMUSG00000026370
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mHS; 1300002P16
    Expression
    Biased expression in liver E18 (RPKM 447.3), liver adult (RPKM 391.9) and 3 other tissues See more
    Orthologs

    Genomic context

    See Hmgcs2 in Genome Data Viewer
    Location:
    3 F2.2; 3 42.74 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (98280431..98310738)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (98084354..98114661)

    Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 40104 Neighboring gene regenerating islet-derived family, member 4 Neighboring gene 3-phosphoglycerate dehydrogenase Neighboring gene predicted gene, 31420

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydroxymethylglutaryl-CoA synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    hydroxymethylglutaryl-CoA synthase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    hydroxymethylglutaryl-CoA synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acetyl-CoA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cholesterol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    cholesterol metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    farnesyl diphosphate biosynthetic process, mevalonate pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    isoprenoid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    steroid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    steroid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    sterol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    mitochondrial inner membrane HDA PubMed 
    mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion HDA PubMed 
    mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    hydroxymethylglutaryl-CoA synthase, mitochondrial
    Names
    3-hydroxy-3-methylglutaryl coenzyme A synthase
    HMG-CoA synthase
    NP_032282.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008256.4NP_032282.2  hydroxymethylglutaryl-CoA synthase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_032282.2

      Status: VALIDATED

      Source sequence(s)
      AC121771, AC147476, AK004865
      Consensus CDS
      CCDS17662.1
      UniProtKB/Swiss-Prot
      P54869
      Related
      ENSMUSP00000088249.2, OTTMUSP00000032467, ENSMUST00000090746.2, OTTMUST00000065217
      Conserved Domains (3) summary
      TIGR01833
      Location:50505
      HMG-CoA-S_euk; 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade
      pfam01154
      Location:53223
      HMG_CoA_synt_N; Hydroxymethylglutaryl-coenzyme A synthase N terminal
      pfam08540
      Location:224505
      HMG_CoA_synt_C; Hydroxymethylglutaryl-coenzyme A synthase C terminal

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

      Range
      98280431..98310738
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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