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    KMT2D lysine methyltransferase 2D [ Pan troglodytes (chimpanzee) ]

    Gene ID: 100610362, updated on 7-Oct-2018

    Summary

    Official Symbol
    KMT2Dprovided by VGNC
    Official Full Name
    lysine methyltransferase 2Dprovided by VGNC
    Primary source
    VGNC:VGNC:8437
    Locus tag
    CK820_G0026884
    See related
    Ensembl:ENSPTRG00000004896
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Pan troglodytes
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
    Also known as
    MLL2
    Orthologs

    Genomic context

    See KMT2D in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    55
    Annotation release Status Assembly Chr Location
    105 current Clint_PTRv2 (GCF_002880755.1) 12 NC_036891.1 (40035607..40078005)
    103 previous assembly Pan_troglodytes-2.1.4 (GCF_000001515.6) 12 NC_006479.3 (40316149..40358497)

    Chromosome 12 - NC_036891.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107967522 Neighboring gene desert hedgehog Neighboring gene RHEB like 1 Neighboring gene uncharacterized LOC107967523 Neighboring gene protein kinase AMP-activated non-catalytic subunit gamma 1 Neighboring gene dendrin Neighboring gene Wnt family member 10B Neighboring gene Wnt family member 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific RNA-sequencing for ten non-human primate species
    • Description: Total RNA sequencing of fifteen different tissues for ten non-human primates
    • BioProject: PRJNA271912
    • Publication: PMID 25392405
    • Analysis date: Tue Apr 3 07:13:10 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    General protein information

    Preferred Names
    histone-lysine N-methyltransferase 2D
    Names
    lysine (K)-specific methyltransferase 2D

    NCBI Reference Sequences (RefSeq)

    RefSeqs of Annotated Genomes: Pan troglodytes Annotation Release 105 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Clint_PTRv2 Primary Assembly

    Genomic

    1. NC_036891.1 Reference Clint_PTRv2 Primary Assembly

      Range
      40035607..40078005
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024347885.1XP_024203653.1  histone-lysine N-methyltransferase 2D isoform X5

      Conserved Domains (13) summary
      smart00398
      Location:19652016
      HMG; high mobility group
      smart00542
      Location:52005287
      FYRC; FY-rich domain, C-terminal region
      smart00317
      Location:53575479
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      smart00508
      Location:54815497
      PostSET; Cysteine-rich motif following a subset of SET domains
      cd15509
      Location:228273
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15513
      Location:14291475
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15597
      Location:13781428
      PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15601
      Location:15061556
      PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15695
      Location:134217
      ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
      cd15698
      Location:49925098
      ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
      pfam05964
      Location:51415192
      FYRN; F/Y-rich N-terminus
      cl22851
      Location:275320
      PHD_SF; PHD finger superfamily
      cl26464
      Location:20512477
      Atrophin-1; Atrophin-1 family
    2. XM_016923503.2XP_016778992.2  histone-lysine N-methyltransferase 2D isoform X1

      Conserved Domains (13) summary
      smart00398
      Location:20242075
      HMG; high mobility group
      smart00542
      Location:52595346
      FYRC; FY-rich domain, C-terminal region
      smart00317
      Location:54165538
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      smart00508
      Location:55405556
      PostSET; Cysteine-rich motif following a subset of SET domains
      cd15509
      Location:228273
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15513
      Location:14291475
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15597
      Location:13781428
      PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15601
      Location:15061556
      PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15695
      Location:134217
      ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
      cd15698
      Location:50515157
      ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
      pfam05964
      Location:52005251
      FYRN; F/Y-rich N-terminus
      cl22851
      Location:275320
      PHD_SF; PHD finger superfamily
      cl26464
      Location:21102536
      Atrophin-1; Atrophin-1 family
    3. XM_016923505.2XP_016778994.2  histone-lysine N-methyltransferase 2D isoform X3

      Conserved Domains (13) summary
      smart00398
      Location:20212072
      HMG; high mobility group
      smart00542
      Location:52565343
      FYRC; FY-rich domain, C-terminal region
      smart00317
      Location:54135535
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      smart00508
      Location:55375553
      PostSET; Cysteine-rich motif following a subset of SET domains
      cd15509
      Location:228273
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15513
      Location:14291475
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15597
      Location:13781428
      PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15601
      Location:15061556
      PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15695
      Location:134217
      ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
      cd15698
      Location:50485154
      ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
      pfam05964
      Location:51975248
      FYRN; F/Y-rich N-terminus
      cl22851
      Location:275320
      PHD_SF; PHD finger superfamily
      cl26464
      Location:21072533
      Atrophin-1; Atrophin-1 family
    4. XM_016923504.2XP_016778993.2  histone-lysine N-methyltransferase 2D isoform X2

      Conserved Domains (13) summary
      smart00398
      Location:20232074
      HMG; high mobility group
      smart00542
      Location:52585345
      FYRC; FY-rich domain, C-terminal region
      smart00317
      Location:54155537
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      smart00508
      Location:55395555
      PostSET; Cysteine-rich motif following a subset of SET domains
      cd15509
      Location:228273
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15513
      Location:14281474
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15597
      Location:13771427
      PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15601
      Location:15051555
      PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15695
      Location:134217
      ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
      cd15698
      Location:50505156
      ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
      pfam05964
      Location:51995250
      FYRN; F/Y-rich N-terminus
      cl22851
      Location:275320
      PHD_SF; PHD finger superfamily
      cl26464
      Location:21092535
      Atrophin-1; Atrophin-1 family
    5. XM_024347884.1XP_024203652.1  histone-lysine N-methyltransferase 2D isoform X4

      Conserved Domains (13) summary
      smart00398
      Location:20202071
      HMG; high mobility group
      smart00542
      Location:52555342
      FYRC; FY-rich domain, C-terminal region
      smart00317
      Location:54125534
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      smart00508
      Location:55365552
      PostSET; Cysteine-rich motif following a subset of SET domains
      cd15509
      Location:228273
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15513
      Location:14281474
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15597
      Location:13771427
      PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15601
      Location:15051555
      PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15695
      Location:134217
      ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
      cd15698
      Location:50475153
      ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
      pfam05964
      Location:51965247
      FYRN; F/Y-rich N-terminus
      cl22851
      Location:275320
      PHD_SF; PHD finger superfamily
      cl26464
      Location:21062532
      Atrophin-1; Atrophin-1 family
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