EDNRA endothelin receptor type A [Sus scrofa (pig)] - Gene

Summary

Official Symbol: EDNRAprovided by VGNC
Official Full Name: endothelin receptor type Aprovided by VGNC
Primary source: VGNC:VGNC:87549
See related: Ensembl:ENSSSCG00000009031 RGD:13910339
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression: Broad expression in heart (RPKM 33.7), lung (RPKM 12.0) and 5 other tissues See more
Orthologs: all
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Genomic context

Location:: chromosome: 8

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2026_06	current	Sscrofa_HxYL_maternal_Yorkshire_Landrace_v2.0 (GCF_054392235.1)	8	NC_139390.1 (87670578..87738578, complement)
106	previous assembly	Sscrofa11.1 (GCF_000003025.6)	8	NC_010450.4 (81210750..81279053, complement)

Chromosome 8 - NC_139390.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

sub-vasomotor concentration of ET-1 leads to vascular dysfunction by impairing endothelium-dependent NO-mediated dilation via p38 kinase-mediated production of superoxide from NADPH oxidase following ETA receptor activation
Title: Endothelin-1 impairs coronary arteriolar dilation: Role of p38 kinase-mediated superoxide production from NADPH oxidase.
PDE5 inhibition and increase in cGMP produce pulmonary vasodilation that is mediated in part through inhibition of the ET pathway, thereby precluding an additional vasodilator effect of ETA/ETB receptor blockade in the presence of PDE5 inhibition.
Title: Pulmonary vasoconstrictor influence of endothelin in exercising swine depends critically on phosphodiesterase 5 activity.
Blocking ET(A) and ET(B) receptors partially protects sinusoidal circulation and tissue oxygenation against stress induced by high intra-abdominal pressure (IAP).
Title: Effect of intra-abdominal pressure on hepatic microcirculation: implications of the endothelin-1 receptor.
Dual endothelin receptor blockade with tezosentan attenuates hypoxia-induced pulmonary vasoconstriction in porcine model.
Title: Dual endothelin receptor blockade with tezosentan markedly attenuates hypoxia-induced pulmonary vasoconstriction in a porcine model.
These results suggest that endothelin released during endotoxemia acts via endothelin A receptors to impair renal medullary blood flow causing ischemia.
Title: Endothelin receptor A antagonism attenuates renal medullary blood flow impairment in endotoxemic pigs.
Anti-endothelin receptor A therapy accelerated the reversal of flow-induced pulmonary arterial disease after flow correction.
Title: Endothelin A receptor blockade improves regression of flow-induced pulmonary vasculopathy in piglets.
study suggests a possible role for endothelin-1(resulting from the actions of endothelin-converting enzyme-1) acting via endothelin receptor A in the control of luteolytic sensitivity in the pig
Title: Endothelin-1, endothelin converting enzyme-1 and endothelin receptors in the porcine corpus luteum.
Report that inhalation of the endothelin-A receptor antagonist LU-135252 at various doses in experimental acute lung injury improved gas exchange and hemodynamics.
Title: Inhalation of the endothelin-A receptor antagonist LU-135252 at various doses in experimental acute lung injury.
Endothelin-A receptor antagonist alters the expression of vasoactive genes and proinflammatory cytokines during hepatic ischemic/reperfusion.
Title: Changes of vasoregulatory gene expression following hepatic ischemia/reperfusion and treatment with endothelin-A receptor blockade.
PKC and MAPK seem to be involved in the regulation of endothelin type A and type B receptor expression in porcine coronary arteries
Title: PKC and MAPK signalling pathways regulate vascular endothelin receptor expression.

Submit: New GeneRIF Correction See all GeneRIFs (13)

General gene information

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Markers

SHGC-59477 (e-PCR)
- UniSTS:25684

MARC_33531-33532:1052491296:3 (e-PCR)
- UniSTS:471505

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables endothelin receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in developmental pigmentation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in endothelin receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in enteric nervous system development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of blood pressure	IEA Inferred from Electronic Annotation more info	PubMed
involved_in vasoconstriction	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: endothelin-1 receptor

Names: ET-A; ET-AR; endothelin A receptor; endothelin receptor subtype A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_214229.1 → NP_999394.1 endothelin-1 receptor precursor

See identical proteins and their annotated locations for NP_999394.1

Status: PROVISIONAL

Source sequence(s)

S80652

UniProtKB/Swiss-Prot

Q29010

Conserved Domains (1) summary

pfam00001
Location:97 → 367

7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_054392235.1-RS_2026_06

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa_HxYL_maternal_Yorkshire_Landrace_v2.0

Genomic

NC_139390.1 Reference Sscrofa_HxYL_maternal_Yorkshire_Landrace_v2.0

Range

87670578..87738578 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021100476.2 → XP_020956135.1 endothelin-1 receptor isoform X1

UniProtKB/TrEMBL

F1RS70

Conserved Domains (1) summary

cd15975
Location:81 → 380

7tmA_ET-AR; endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_021100475.2 → XP_020956134.1 endothelin-1 receptor isoform X1

UniProtKB/TrEMBL

F1RS70

Related

ENSSSCP00000009635.3

Conserved Domains (1) summary

cd15975
Location:81 → 380

7tmA_ET-AR; endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors