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    N4BP1 NEDD4 binding protein 1 [ Homo sapiens (human) ]

    Gene ID: 9683, updated on 5-Sep-2021

    Summary

    Official Symbol
    N4BP1provided by HGNC
    Official Full Name
    NEDD4 binding protein 1provided by HGNC
    Primary source
    HGNC:HGNC:29850
    See related
    Ensembl:ENSG00000102921 MIM:619138
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Ubiquitous expression in lung (RPKM 13.3), esophagus (RPKM 11.1) and 25 other tissues See more
    Orthologs
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    Genomic context

    See N4BP1 in Genome Data Viewer
    Location:
    16q12.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (48538726..48610214, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (48572637..48644091, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene chromosome 18 open reading frame 32 pseudogene Neighboring gene molybdenum cofactor synthesis 1 pseudogene 1 Neighboring gene uncharacterized LOC112268166 Neighboring gene probable ribosome biogenesis protein RLP24 pseudogene Neighboring gene ribosomal protein S2 pseudogene 44 Neighboring gene uncharacterized LOC105371240 Neighboring gene RNA, U6 small nuclear 257, pseudogene Neighboring gene Kruppel like factor 8 pseudogene 1 Neighboring gene VISTA enhancer hs101

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Phenotypes

    Associated conditions

    Description Tests
    Genome-wide association analysis implicates the involvement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis.
    GeneReviews: Not available
    Genome-wide association study of autistic-like traits in a general population study of young adults.
    GeneReviews: Not available

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ31821, KIAA0615, MGC176730

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ribonuclease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in PML body IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in PML body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153029.4NP_694574.3  NEDD4-binding protein 1

      See identical proteins and their annotated locations for NP_694574.3

      Status: VALIDATED

      Source sequence(s)
      AB014515, AK026937, AK056383, AK124782, AL831882, BC051897
      Consensus CDS
      CCDS45479.1
      UniProtKB/Swiss-Prot
      O75113
      Related
      ENSP00000262384.3, ENST00000262384.4
      Conserved Domains (1) summary
      pfam11977
      Location:616769
      RNase_Zc3h12a; Zc3h12a-like Ribonuclease NYN domain

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

      Range
      48538726..48610214 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011523482.1XP_011521784.1  NEDD4-binding protein 1 isoform X1

      Conserved Domains (1) summary
      pfam11977
      Location:616746
      RNase_Zc3h12a; Zc3h12a-like Ribonuclease NYN domain

    RNA

    1. XR_001752040.1 RNA Sequence

    2. XR_001752039.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_014664.1: Suppressed sequence

      Description
      NM_014664.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
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