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    ORAI3 ORAI calcium release-activated calcium modulator 3 [ Homo sapiens (human) ]

    Gene ID: 93129, updated on 22-Sep-2022

    Summary

    Official Symbol
    ORAI3provided by HGNC
    Official Full Name
    ORAI calcium release-activated calcium modulator 3provided by HGNC
    Primary source
    HGNC:HGNC:28185
    See related
    Ensembl:ENSG00000175938 MIM:610930; AllianceGenome:HGNC:28185
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TMEM142C
    Summary
    Predicted to enable store-operated calcium channel activity. Predicted to be involved in store-operated calcium entry. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in prostate (RPKM 8.2), testis (RPKM 7.2) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See ORAI3 in Genome Data Viewer
    Location:
    16p11.2
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (30949068..30954938)
    110 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (31336531..31342399)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (30960389..30966259)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene FBXL19 antisense RNA 1 Neighboring gene F-box and leucine rich repeat protein 19 Neighboring gene Sharpr-MPRA regulatory region 7559 Neighboring gene SET domain containing 1A, histone lysine methyltransferase Neighboring gene hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Homology

    Clone Names

    • MGC13024

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables store-operated calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in store-operated calcium entry IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    protein orai-3
    Names
    transmembrane protein 142C

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_152288.3NP_689501.1  protein orai-3

      See identical proteins and their annotated locations for NP_689501.1

      Status: VALIDATED

      Source sequence(s)
      AC135048
      Consensus CDS
      CCDS10697.1
      UniProtKB/Swiss-Prot
      Q96BI8, Q9BRQ5
      UniProtKB/TrEMBL
      A0A024QZA7
      Related
      ENSP00000322249.4, ENST00000318663.5
      Conserved Domains (1) summary
      pfam07856
      Location:48276
      Orai-1; Mediator of CRAC channel activity

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      30949068..30954938
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      31336531..31342399
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)