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    PEX11G peroxisomal biogenesis factor 11 gamma [ Homo sapiens (human) ]

    Gene ID: 92960, updated on 22-Jun-2021

    Summary

    Official Symbol
    PEX11Gprovided by HGNC
    Official Full Name
    peroxisomal biogenesis factor 11 gammaprovided by HGNC
    Primary source
    HGNC:HGNC:20208
    See related
    Ensembl:ENSG00000104883 MIM:607583
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene is a member of the PEX11 family. This family is reported to regulate the number and size of peroxisomes in evolutionarily distant organisms. The protein encoded by this gene may induce clustering of peroxisomes. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
    Expression
    Broad expression in testis (RPKM 3.6), kidney (RPKM 2.2) and 23 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See PEX11G in Genome Data Viewer
    Location:
    19p13.2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (7476875..7494977, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (7541761..7554286, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene insulin receptor Neighboring gene Rho/Rac guanine nucleotide exchange factor 18 Neighboring gene uncharacterized LOC107985284 Neighboring gene Sharpr-MPRA regulatory region 11228 Neighboring gene uncharacterized LOC105372261 Neighboring gene testis expressed 45 Neighboring gene zinc finger protein 358

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC4281

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in peroxisome fission IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in peroxisome fission IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of peroxisome size IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in integral component of peroxisomal membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intrinsic component of peroxisomal membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in peroxisomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    peroxisomal membrane protein 11C
    Names
    PEX11-gamma
    Pex11pgamma
    peroxin Pex11p gamma
    peroxin-11C
    peroxisomal biogenesis factor 11C
    peroxisomal biogenesis factor 11G
    protein PEX11 homolog gamma

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270539.2NP_001257468.1  peroxisomal membrane protein 11C isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      BC008780, BI833221, HY002496
      UniProtKB/Swiss-Prot
      Q96HA9
      Related
      ENSP00000472956.1, ENST00000593547.1
      Conserved Domains (1) summary
      pfam05648
      Location:4160
      PEX11; Peroxisomal biogenesis factor 11 (PEX11)
    2. NM_001300881.2NP_001287810.1  peroxisomal membrane protein 11C isoform 3

      See identical proteins and their annotated locations for NP_001287810.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate 3' terminal exon, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 3, which has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AL833945, BC008780
      Consensus CDS
      CCDS77227.1
      UniProtKB/Swiss-Prot
      Q96HA9
      Conserved Domains (1) summary
      pfam05648
      Location:1159
      PEX11; Peroxisomal biogenesis factor 11 (PEX11)
    3. NM_080662.4NP_542393.1  peroxisomal membrane protein 11C isoform 1

      See identical proteins and their annotated locations for NP_542393.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC008780, HY002496
      Consensus CDS
      CCDS12178.1
      UniProtKB/Swiss-Prot
      Q96HA9
      Related
      ENSP00000221480.1, ENST00000221480.6
      Conserved Domains (1) summary
      pfam05648
      Location:4229
      PEX11; Peroxisomal biogenesis factor 11 (PEX11)

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

      Range
      7476875..7494977 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011528428.1XP_011526730.1  peroxisomal membrane protein 11C isoform X4

      See identical proteins and their annotated locations for XP_011526730.1

      UniProtKB/Swiss-Prot
      Q96HA9
      Related
      ENSP00000472216.1, ENST00000593942.5
      Conserved Domains (1) summary
      pfam05648
      Location:1159
      PEX11; Peroxisomal biogenesis factor 11 (PEX11)
    2. XM_011528429.2XP_011526731.1  peroxisomal membrane protein 11C isoform X4

      See identical proteins and their annotated locations for XP_011526731.1

      UniProtKB/Swiss-Prot
      Q96HA9
      Conserved Domains (1) summary
      pfam05648
      Location:1159
      PEX11; Peroxisomal biogenesis factor 11 (PEX11)
    3. XM_011528431.2XP_011526733.1  peroxisomal membrane protein 11C isoform X4

      See identical proteins and their annotated locations for XP_011526733.1

      UniProtKB/Swiss-Prot
      Q96HA9
      Conserved Domains (1) summary
      pfam05648
      Location:1159
      PEX11; Peroxisomal biogenesis factor 11 (PEX11)
    4. XM_011528432.1XP_011526734.1  peroxisomal membrane protein 11C isoform X5

      Conserved Domains (1) summary
      pfam05648
      Location:4146
      PEX11; Peroxisomal biogenesis factor 11 (PEX11)
    5. XM_005272506.2XP_005272563.1  peroxisomal membrane protein 11C isoform X2

      Conserved Domains (1) summary
      pfam05648
      Location:4208
      PEX11; Peroxisomal biogenesis factor 11 (PEX11)
    6. XM_011528427.2XP_011526729.1  peroxisomal membrane protein 11C isoform X3

      Conserved Domains (1) summary
      pfam05648
      Location:4143
      PEX11; Peroxisomal biogenesis factor 11 (PEX11)
    7. XM_011528426.2XP_011526728.1  peroxisomal membrane protein 11C isoform X1

      Conserved Domains (1) summary
      pfam05648
      Location:4143
      PEX11; Peroxisomal biogenesis factor 11 (PEX11)
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