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    ADAM9 ADAM metallopeptidase domain 9 [ Homo sapiens (human) ]

    Gene ID: 8754, updated on 6-May-2021

    Summary

    Official Symbol
    ADAM9provided by HGNC
    Official Full Name
    ADAM metallopeptidase domain 9provided by HGNC
    Primary source
    HGNC:HGNC:216
    See related
    Ensembl:ENSG00000168615 MIM:602713
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MCMP; MDC9; CORD9; Mltng
    Summary
    This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. Several alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2010]
    Expression
    Ubiquitous expression in gall bladder (RPKM 19.8), urinary bladder (RPKM 16.8) and 24 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ADAM9 in Genome Data Viewer
    Location:
    8p11.22
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    109.20210226 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (38996767..39105261)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (38854492..38962780)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene pleckstrin homology domain containing A2 Neighboring gene HtrA serine peptidase 4 Neighboring gene TM2 domain containing 2 Neighboring gene small nucleolar RNA, C/D box 38D Neighboring gene ADAM metallopeptidase domain 32 Neighboring gene ribosomal protein L3 pseudogene 10 Neighboring gene lysine acetyltransferase 2B pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0021

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables SH3 domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables SH3 domain binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables collagen binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables integrin binding IC
    Inferred by Curator
    more info
    PubMed 
    enables integrin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables integrin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables laminin binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables metalloendopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metalloendopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables metallopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase C binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in activation of MAPKK activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell adhesion mediated by integrin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell adhesion mediated by integrin ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell-cell adhesion mediated by integrin IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cell-cell adhesion mediated by integrin IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cell-matrix adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to lipopolysaccharide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in integrin-mediated signaling pathway IC
    Inferred by Curator
    more info
    PubMed 
    involved_in keratinocyte differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in membrane protein ectodomain proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in membrane protein ectodomain proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within membrane protein ectodomain proteolysis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in membrane protein ectodomain proteolysis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within membrane protein intracellular domain proteolysis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in monocyte activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell adhesion mediated by integrin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of keratinocyte migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of macrophage fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of membrane protein ectodomain proteolysis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of protein secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to antineoplastic agent IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to calcium ion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to glucocorticoid ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in response to hydrogen peroxide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to laminar fluid shear stress IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to manganese ion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to tumor necrosis factor IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in transforming growth factor beta receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in transforming growth factor beta receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in transforming growth factor beta receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in extracellular exosome HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in focal adhesion HDA PubMed 
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intrinsic component of external side of plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 

    General protein information

    Preferred Names
    disintegrin and metalloproteinase domain-containing protein 9
    Names
    ADAM metallopeptidase domain 9 (meltrin gamma)
    cellular disintegrin-related protein
    cone rod dystrophy 9
    metalloprotease/disintegrin/cysteine-rich protein 9
    myeloma cell metalloproteinase

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016335.1 RefSeqGene

      Range
      5001..113276
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_003816.3NP_003807.1  disintegrin and metalloproteinase domain-containing protein 9 precursor

      See identical proteins and their annotated locations for NP_003807.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the protein coding transcript.
      Source sequence(s)
      AC105091, AC108863
      Consensus CDS
      CCDS6112.1
      UniProtKB/Swiss-Prot
      Q13443
      Related
      ENSP00000419446.2, ENST00000487273.7
      Conserved Domains (5) summary
      smart00608
      Location:500636
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:212404
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:423497
      Disintegrin; Disintegrin
      pfam01421
      Location:212406
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:55162
      Pep_M12B_propep; Reprolysin family propeptide

    RNA

    1. NR_027638.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) omits a coding exon resulting in a frameshift and premature stop codon compared to variant 1. This suggests that the transcript is subject to nonsense-mediated decay (NMD) and therefore a predicted protein is not annotated.
      Source sequence(s)
      AC105091, AC108863, AV708278, BC027996, BC126406, BC143923
      Related
      ENST00000481873.7
    2. NR_027639.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) omits a coding exon resulting in a frameshift and premature stop codon compared to variant 1. This suggests that the transcript is subject to nonsense-mediated decay (NMD) and therefore a predicted protein is not annotated.
      Source sequence(s)
      AC105091, AC108863, AV708278, BC027996, BC143924
      Related
      ENST00000468065.5
    3. NR_027878.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 3' coding region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC105091, AC108863
      Related
      ENST00000379917.7

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

      Range
      38996767..39105261
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011544682.2XP_011542984.1  disintegrin and metalloproteinase domain-containing protein 9 isoform X2

      Conserved Domains (5) summary
      smart00608
      Location:482618
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:194386
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:405479
      Disintegrin; Disintegrin
      pfam01421
      Location:194388
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:37144
      Pep_M12B_propep; Reprolysin family propeptide
    2. XM_017013942.1XP_016869431.1  disintegrin and metalloproteinase domain-containing protein 9 isoform X1

    RNA

    1. XR_001745616.2 RNA Sequence

      Related
      ENST00000676765.1
    2. XR_001745618.2 RNA Sequence

    3. XR_001745617.1 RNA Sequence

    4. XR_001745615.1 RNA Sequence

    Reference GRCh38.p13 ALT_REF_LOCI_1

    Genomic

    1. NT_187577.1 Reference GRCh38.p13 ALT_REF_LOCI_1

      Range
      7546..10944
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001005845.1: Suppressed sequence

      Description
      NM_001005845.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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