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    B3GALT2 beta-1,3-galactosyltransferase 2 [ Homo sapiens (human) ]

    Gene ID: 8707, updated on 8-Jul-2021

    Summary

    Official Symbol
    B3GALT2provided by HGNC
    Official Full Name
    beta-1,3-galactosyltransferase 2provided by HGNC
    Primary source
    HGNC:HGNC:917
    See related
    Ensembl:ENSG00000162630 MIM:603018
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GLCT2; BETA3GALT2; beta3Gal-T2
    Summary
    This gene is a member of the beta-1,3-galactosyltransferase (beta3GalT) gene family. This family encodes type II membrane-bound glycoproteins with diverse enzymatic functions using different donor substrates (UDP-galactose and UDP-N-acetylglucosamine) and different acceptor sugars (N-acetylglucosamine, galactose, N-acetylgalactosamine). The beta3GalT genes are distantly related to the Drosophila Brainiac gene and have the protein coding sequence contained in a single exon. The beta3GalT proteins also contain conserved sequences not found in the beta4GalT or alpha3GalT proteins. The carbohydrate chains synthesized by these enzymes are designated as type 1, whereas beta4GalT enzymes synthesize type 2 carbohydrate chains. The ratio of type 1:type 2 chains changes during embryogenesis. By sequence similarity, the beta3GalT genes fall into at least two groups: beta3GalT4 and 4 other beta3GalT genes (beta3GalT1-3, beta3GalT5). This gene encodes a protein that functions in N-linked glycoprotein glycosylation and shows strict donor substrate specificity for UDP-galactose. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in gall bladder (RPKM 11.6), brain (RPKM 11.4) and 11 other tissues See more
    Orthologs
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    Genomic context

    See B3GALT2 in Genome Data Viewer
    Location:
    1q31.2
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (193178730..193186613, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (193147860..193155743, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929160 Neighboring gene microRNA 1278 Neighboring gene cell division cycle 73 Neighboring gene long intergenic non-protein coding RNA 1031 Neighboring gene Sharpr-MPRA regulatory region 5855 Neighboring gene ribosomal protein L23a pseudogene 22

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp160, precursor env Oligosaccharide side-chains of HIV-1 gp160 are processed by glycosidase I and II, mannosidase I and II, acetylglucosaminyl transferase I and II, and fucosyl, galactosyl and sialyl transferases in both the endoplasmic reticulum and golgi apparatus PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    General protein information

    Preferred Names
    beta-1,3-galactosyltransferase 2
    Names
    UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
    UDP-galactose:2-acetamido-2-deoxy-D-glucose 3beta-galactosyltransferase 2
    beta-1,3-GalTase 2
    beta-3-galt2
    NP_003774.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_052990.1 RefSeqGene

      Range
      5001..12884
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_003783.3NP_003774.1  beta-1,3-galactosyltransferase 2

      See identical proteins and their annotated locations for NP_003774.1

      Status: REVIEWED

      Source sequence(s)
      AK314116, AL390863, DA116294
      Consensus CDS
      CCDS1383.1
      UniProtKB/Swiss-Prot
      O43825
      Related
      ENSP00000356404.4, ENST00000367434.5
      Conserved Domains (1) summary
      pfam01762
      Location:165359
      Galactosyl_T; Galactosyltransferase

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      193178730..193186613 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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