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    VAMP8 vesicle associated membrane protein 8 [ Homo sapiens (human) ]

    Gene ID: 8673, updated on 6-Sep-2021

    Summary

    Official Symbol
    VAMP8provided by HGNC
    Official Full Name
    vesicle associated membrane protein 8provided by HGNC
    Primary source
    HGNC:HGNC:12647
    See related
    Ensembl:ENSG00000118640 MIM:603177
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EDB; VAMP-8
    Summary
    This gene encodes an integral membrane protein that belongs to the synaptobrevin/vesicle-associated membrane protein subfamily of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs). The encoded protein is involved in the fusion of synaptic vesicles with the presynaptic membrane.[provided by RefSeq, Jun 2010]
    Expression
    Ubiquitous expression in colon (RPKM 79.3), placenta (RPKM 77.9) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See VAMP8 in Genome Data Viewer
    Location:
    2p11.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (85577535..85582031)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (85804709..85809154)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene methionine adenosyltransferase 2A Neighboring gene gamma-glutamyl carboxylase Neighboring gene RNA, 7SL, cytoplasmic 126, pseudogene Neighboring gene vesicle associated membrane protein 5 Neighboring gene ring finger protein 181

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study.
    GeneReviews: Not available

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables chloride channel inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables syntaxin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in SNARE complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in autophagosome maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in autophagosome membrane docking IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in defense response to virus IEA
    Inferred from Electronic Annotation
    more info
     
    NOT involved_in eosinophil degranulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mucus secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in mucus secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of secretion by cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT involved_in neutrophil degranulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of histamine secretion by mast cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of protein localization to plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within viral entry into host cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of SNARE complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in azurophil granule membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in azurophil granule membrane TAS
    Traceable Author Statement
    more info
     
    located_in clathrin-coated endocytic vesicle membrane TAS
    Traceable Author Statement
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in early endosome TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in late endosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in mucin granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mucin granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in phagocytic vesicle membrane TAS
    Traceable Author Statement
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in recycling endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in recycling endosome membrane TAS
    Traceable Author Statement
    more info
     
    located_in secretory granule membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in secretory granule membrane TAS
    Traceable Author Statement
    more info
     
    located_in specific granule membrane TAS
    Traceable Author Statement
    more info
     
    located_in tertiary granule membrane TAS
    Traceable Author Statement
    more info
     
    located_in vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    vesicle-associated membrane protein 8
    Names
    vesicle-associated membrane protein 8 (endobrevin)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_022887.1 RefSeqGene

      Range
      5096..9541
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_003761.5NP_003752.2  vesicle-associated membrane protein 8

      See identical proteins and their annotated locations for NP_003752.2

      Status: REVIEWED

      Source sequence(s)
      BC001634, BM702226, BX092149
      Consensus CDS
      CCDS1979.1
      UniProtKB/Swiss-Prot
      Q9BV40
      Related
      ENSP00000263864.5, ENST00000263864.10
      Conserved Domains (1) summary
      cd15868
      Location:1077
      R-SNARE_VAMP8; SNARE motif of VAMP8

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

      Range
      85577535..85582031
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017005170.1XP_016860659.1  vesicle-associated membrane protein 8 isoform X1

      UniProtKB/TrEMBL
      B8ZZT4
      Related
      ENSP00000387094.1, ENST00000409760.1
      Conserved Domains (1) summary
      cl22856
      Location:1055
      SNARE; SNARE motif
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