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    OASL 2'-5'-oligoadenylate synthetase like [ Homo sapiens (human) ]

    Gene ID: 8638, updated on 16-Oct-2021

    Summary

    Official Symbol
    OASLprovided by HGNC
    Official Full Name
    2'-5'-oligoadenylate synthetase likeprovided by HGNC
    Primary source
    HGNC:HGNC:8090
    See related
    Ensembl:ENSG00000135114 MIM:603281
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OASL1; OASLd; TRIP14; TRIP-14; p59OASL; p59 OASL; p59-OASL
    Expression
    Biased expression in bone marrow (RPKM 19.8), stomach (RPKM 11.1) and 13 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See OASL in Genome Data Viewer
    Location:
    12q24.31
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (121018882..121039242, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (121458095..121477045, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene HNF1A antisense RNA 1 Neighboring gene HNF1 homeobox A Neighboring gene chromosome 12 open reading frame 43 Neighboring gene 2'-5' oligoadenylate synthetase like 2, pseudogene Neighboring gene uncharacterized LOC105378258

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits.
    GeneReviews: Not available
    Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women.
    GeneReviews: Not available
    Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1α as a master regulator of plasma protein fucosylation.
    GeneReviews: Not available
    New variants including ARG1 polymorphisms associated with C-reactive protein levels identified by genome-wide association and pathway analysis.
    GeneReviews: Not available
    Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
    GeneReviews: Not available

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of 2'-5'-oligoadenylate synthetase-like (OASL) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 and the viral protein Tat modulate the expression of 2'-5'-oligoadenylate synthetase-like (OASL; p59-OASL) in immature dendritic cells and monocyte-derived macrophages PubMed
    Vpr vpr HIV-1 Vpr upregulates the gene expression of OASL in human monocyte-derived dendritic cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    NOT enables 2'-5'-oligoadenylate synthetase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA binding HDA PubMed 
    enables double-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables double-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables thyroid hormone receptor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in membrane HDA PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    2'-5'-oligoadenylate synthase-like protein
    Names
    2'-5'-OAS-RP
    2'-5'-OAS-related protein
    59 kDa 2'-5'-oligoadenylate synthase-like protein
    59 kDa 2'-5'-oligoadenylate synthetase-like protein
    TR-interacting protein 14
    thyroid receptor-interacting protein 14

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001261825.2NP_001248754.1  2'-5'-oligoadenylate synthase-like protein isoform c

      See identical proteins and their annotated locations for NP_001248754.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two consecutive exons in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
      Source sequence(s)
      AC079602
      Consensus CDS
      CCDS73536.1
      UniProtKB/Swiss-Prot
      Q15646
      Related
      ENSP00000479512.1, ENST00000620239.5
      Conserved Domains (5) summary
      cd05400
      Location:29212
      NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
      smart00213
      Location:304372
      UBQ; Ubiquitin homologues
      pfam00240
      Location:309375
      ubiquitin; Ubiquitin family
      pfam10421
      Location:167219
      OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
      cl00155
      Location:224303
      UBQ; Ubiquitin-like proteins
    2. NM_001395418.1NP_001382347.1  2'-5'-oligoadenylate synthase-like protein isoform b

      Status: VALIDATED

      Source sequence(s)
      AC079602
      Conserved Domains (2) summary
      cd05400
      Location:29212
      NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
      pfam10421
      Location:168219
      OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
    3. NM_001395419.1NP_001382348.1  2'-5'-oligoadenylate synthase-like protein isoform d

      Status: VALIDATED

      Source sequence(s)
      AC079602
      Conserved Domains (2) summary
      cd05400
      Location:29212
      NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
      pfam10421
      Location:168349
      OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
    4. NM_003733.4NP_003724.1  2'-5'-oligoadenylate synthase-like protein isoform a

      See identical proteins and their annotated locations for NP_003724.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AC079602
      Consensus CDS
      CCDS9211.1
      UniProtKB/Swiss-Prot
      Q15646
      Related
      ENSP00000257570.4, ENST00000257570.9
      Conserved Domains (4) summary
      cd05400
      Location:29212
      NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
      cd01811
      Location:354433
      OASL_repeat1; 2'-5' oligoadenylate synthetase-like protein, repeat 1 of 2
      pfam00240
      Location:436506
      ubiquitin; Ubiquitin family
      pfam10421
      Location:168351
      OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
    5. NM_198213.3NP_937856.1  2'-5'-oligoadenylate synthase-like protein isoform b

      See identical proteins and their annotated locations for NP_937856.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the coding region, which results in a frameshift, compared to variant 1. The encoded isoform (b) is shorter and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AC079602
      Consensus CDS
      CCDS9212.1
      UniProtKB/Swiss-Prot
      Q15646
      Related
      ENSP00000341125.5, ENST00000339275.10
      Conserved Domains (2) summary
      cd05400
      Location:29212
      NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
      pfam10421
      Location:168219
      OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

      Range
      121018882..121039242 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017020140.1XP_016875629.1  2'-5'-oligoadenylate synthase-like protein isoform X1

      Related
      ENSP00000505685.1, ENST00000680620.1
      Conserved Domains (2) summary
      cd05400
      Location:29212
      NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
      pfam10421
      Location:168349
      OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
    2. XM_017020141.1XP_016875630.1  2'-5'-oligoadenylate synthase-like protein isoform X2

      UniProtKB/Swiss-Prot
      Q15646
      Related
      ENSP00000444127.2, ENST00000543677.2
      Conserved Domains (2) summary
      cd05400
      Location:29212
      NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
      pfam10421
      Location:168219
      OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
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