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    NDST2 N-deacetylase and N-sulfotransferase 2 [ Homo sapiens (human) ]

    Gene ID: 8509, updated on 21-Apr-2019

    Summary

    Official Symbol
    NDST2provided by HGNC
    Official Full Name
    N-deacetylase and N-sulfotransferase 2provided by HGNC
    Primary source
    HGNC:HGNC:7681
    See related
    Ensembl:ENSG00000166507 MIM:603268
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NST2; HSST2; N-HSST 2
    Summary
    This gene encodes a member of the N-deacetylase/N-sulfotransferase subfamily of the sulfotransferase 1 proteins. The encoded enzyme has dual functions in processing glucosamine and heparin polymers, including N-deacetylation and N-sulfation. The encoded protein may be localized to the Golgi. [provided by RefSeq, Feb 2009]
    Expression
    Ubiquitous expression in spleen (RPKM 13.3), bone marrow (RPKM 9.9) and 25 other tissues See more
    Orthologs

    Genomic context

    See NDST2 in Genome Data Viewer
    Location:
    10q22.2
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 10 NC_000010.11 (73801911..73811849, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (75561669..75571589, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 1 Neighboring gene zinc finger SWIM-type containing 8 Neighboring gene ZSWIM8 antisense RNA 1 Neighboring gene calcium/calmodulin dependent protein kinase II gamma Neighboring gene chromosome 10 open reading frame 55 Neighboring gene plasminogen activator, urokinase

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC129697, MGC129705

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    glycosaminoglycan biosynthetic process TAS
    Traceable Author Statement
    more info
     
    heparin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi membrane TAS
    Traceable Author Statement
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2
    Names
    N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
    N-heparan sulfate sulfotransferase 2
    glucosaminyl N-deacetylase/N-sulfotransferase 2
    NP_001317036.1
    NP_003626.1
    XP_005270313.1
    XP_011538612.1
    XP_016872346.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_046905.1 RefSeqGene

      Range
      5001..14921
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001330107.1NP_001317036.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC022400, AL045074, AU125430, BC035711, CB959603, CN266932, DN999958
      Consensus CDS
      CCDS81476.1
      UniProtKB/Swiss-Prot
      P52849
      UniProtKB/TrEMBL
      S4R438
      Related
      ENSP00000492373.1, ENST00000639645.1
      Conserved Domains (2) summary
      pfam00685
      Location:603797
      Sulfotransfer_1; Sulfotransferase domain
      pfam12062
      Location:25514
      HSNSD; heparan sulfate-N-deacetylase
    2. NM_003635.3NP_003626.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 isoform 1

      See identical proteins and their annotated locations for NP_003626.1

      Status: REVIEWED

      Source sequence(s)
      AK303648, BC035711
      Consensus CDS
      CCDS7335.1
      UniProtKB/Swiss-Prot
      P52849
      UniProtKB/TrEMBL
      B4E139
      Related
      ENSP00000310657.6, ENST00000309979.10
      Conserved Domains (2) summary
      pfam00685
      Location:603852
      Sulfotransfer_1; Sulfotransferase domain
      pfam12062
      Location:25514
      HSNSD; heparan sulfate-N-deacetylase

    RNA

    1. NR_160743.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC022400
    2. NR_160744.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC022400
    3. NR_160745.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) is represented as non-coding because it lacks the coding region found in variant 1.
      Source sequence(s)
      AC022400, AK303648, BC018681

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p12 Primary Assembly

      Range
      73801911..73811849 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017016857.1XP_016872346.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 isoform X3

      UniProtKB/TrEMBL
      B4DE98
      Conserved Domains (2) summary
      pfam00685
      Location:126375
      Sulfotransfer_1; Sulfotransferase domain
      pfam12062
      Location:137
      HSNSD; heparan sulfate-N-deacetylase
    2. XM_011540310.3XP_011538612.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 isoform X1

      See identical proteins and their annotated locations for XP_011538612.1

      UniProtKB/Swiss-Prot
      P52849
      Conserved Domains (2) summary
      pfam00685
      Location:603852
      Sulfotransfer_1; Sulfotransferase domain
      pfam12062
      Location:25514
      HSNSD; heparan sulfate-N-deacetylase
    3. XM_005270256.4XP_005270313.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 isoform X2

      See identical proteins and their annotated locations for XP_005270313.1

      UniProtKB/TrEMBL
      B4DU70
      Conserved Domains (2) summary
      pfam00685
      Location:229478
      Sulfotransfer_1; Sulfotransferase domain
      pfam12062
      Location:1140
      HSNSD; heparan sulfate-N-deacetylase

    RNA

    1. XR_002957036.1 RNA Sequence

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