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    TOC1 CCT motif -containing response regulator protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836259, updated on 18-Apr-2019

    Summary

    Gene symbol
    TOC1
    Gene description
    CCT motif -containing response regulator protein
    Primary source
    Araport:AT5G61380
    Locus tag
    AT5G61380
    Gene type
    protein coding
    RNA name
    CCT motif -containing response regulator protein
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    APRR1; AtTOC1; MFB13.13; MFB13_13; PRR1; PSEUDO-RESPONSE REGULATOR 1; TIMING OF CAB EXPRESSION 1
    Summary
    Pseudo response regulator involved in the generation of circadian rhythms. TOC1 appears to shorten the period of circumnutation speed. TOC1 contributes to the plant fitness (carbon fixation, biomass) by influencing the circadian clock period. PRR3 may increase the stability of TOC1 by preventing interactions between TOC1 and the F-box protein ZTL. Expression of TOC1 is correlated with rhythmic changes in chromatin organization.

    Genomic context

    See TOC1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    6
    Sequence:
    Chromosome: 5; NC_003076.8 (24674963..24678550)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Protein kinase superfamily protein Neighboring gene hypothetical protein Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene Polynucleotidyl transferase, ribonuclease H-like superfamily protein Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Circadian rhythm - plant, organism-specific biosystem (from KEGG)
      Circadian rhythm - plant, organism-specific biosystemThe circadian system is an endogenous rhythm with the period of about 24 hours to provide temporal organization of biological activity. In Arabidopsis the circadian oscillator at the core of this sys...
    • Circadian rhythm - plant, conserved biosystem (from KEGG)
      Circadian rhythm - plant, conserved biosystemThe circadian system is an endogenous rhythm with the period of about 24 hours to provide temporal organization of biological activity. In Arabidopsis the circadian oscillator at the core of this sys...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    NM_125531.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphorelay response regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    NOT transcription regulatory region DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    circadian rhythm IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    circadian rhythm TAS
    Traceable Author Statement
    more info
    PubMed 
    circumnutation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    flower development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphorelay signal transduction system IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription, DNA-templated ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    regulation of transcription, DNA-templated TAS
    Traceable Author Statement
    more info
    PubMed 
    transcription, DNA-templated TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISM
    Inferred from Sequence Model
    more info
     
    nucleus TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    CCT motif -containing response regulator protein
    NP_200946.1
    • TIMING OF CAB EXPRESSION 1 (TOC1); CONTAINS InterPro DOMAIN/s: CheY-like (InterPro:IPR011006), Signal transduction response regulator, receiver domain (InterPro:IPR001789), CCT domain (InterPro:IPR010402); BEST Arabidopsis thaliana protein match is: pseudo-response regulator 3 (TAIR:AT5G60100.3); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      24674963..24678550
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125531.4NP_200946.1  CCT motif -containing response regulator protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_200946.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LKL2
      UniProtKB/TrEMBL
      A0A178UC73
      Conserved Domains (4) summary
      COG0745
      Location:20131
      OmpR; DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription]
      cd00156
      Location:22131
      REC; Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; ...
      pfam08430
      Location:402528
      Forkhead_N; Forkhead N-terminal region
      pfam06203
      Location:533575
      CCT; CCT motif
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