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    H3C1 H3 clustered histone 1 [ Homo sapiens (human) ]

    Gene ID: 8350, updated on 2-Mar-2021

    Summary

    Official Symbol
    H3C1provided by HGNC
    Official Full Name
    H3 clustered histone 1provided by HGNC
    Primary source
    HGNC:HGNC:4766
    See related
    Ensembl:ENSG00000275714 MIM:602810
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    H3/A; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3FA; H3C10; H3C11; H3C12; HIST1H3A
    Summary
    Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
    Orthologs
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    Genomic context

    See H3C1 in Genome Data Viewer
    Location:
    6p22.2
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    109.20210226 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (26020451..26020958)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (26020679..26021186)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene H3 histone pseudogene 26 Neighboring gene H1.1 linker histone, cluster member Neighboring gene H4 clustered histone 1 Neighboring gene H4 clustered histone 2

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 is identified to have a physical interaction with histone cluster 1, H3a (HIST1H3A) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    Tat tat HIV-1 Tat peptides bind core histones H2A, H2B, H3 and H4, and Tat protein recruits histone acetyltransferases to the HIV-1 LTR promoter leading to acetylation of histones H3 and H4, derepressing chromatin structure and increasing NFkappaB responsiveness PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    cadherin binding HDA PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    DNA replication-dependent nucleosome assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    blood coagulation TAS
    Traceable Author Statement
    more info
     
    cellular protein metabolic process TAS
    Traceable Author Statement
    more info
     
    chromatin organization TAS
    Traceable Author Statement
    more info
     
    interleukin-7-mediated signaling pathway TAS
    Traceable Author Statement
    more info
     
    negative regulation of gene expression, epigenetic TAS
    Traceable Author Statement
    more info
     
    nucleosome assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    rDNA heterochromatin assembly TAS
    Traceable Author Statement
    more info
     
    regulation of gene silencing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of gene silencing by miRNA TAS
    Traceable Author Statement
    more info
     
    regulation of megakaryocyte differentiation TAS
    Traceable Author Statement
    more info
     
    telomere organization TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular exosome HDA PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
     
    membrane HDA PubMed 
    nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus HDA PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    histone H3.1
    Names
    H3 histone family, member A
    histone 1, H3a
    histone H3/a
    histone cluster 1 H3 family member a
    histone cluster 1, H3a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003529.3NP_003520.1  histone H3.1

      See identical proteins and their annotated locations for NP_003520.1

      Status: REVIEWED

      Source sequence(s)
      U91328
      Consensus CDS
      CCDS4570.1
      UniProtKB/Swiss-Prot
      P68431
      Related
      ENSP00000480826.1, ENST00000613854.1
      Conserved Domains (1) summary
      PTZ00018
      Location:1136
      PTZ00018; histone H3; Provisional

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

      Range
      26020451..26020958
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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