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    NAA10 N-alpha-acetyltransferase 10, NatA catalytic subunit [ Homo sapiens (human) ]

    Gene ID: 8260, updated on 19-Sep-2021

    Summary

    Official Symbol
    NAA10provided by HGNC
    Official Full Name
    N-alpha-acetyltransferase 10, NatA catalytic subunitprovided by HGNC
    Primary source
    HGNC:HGNC:18704
    See related
    Ensembl:ENSG00000102030 MIM:300013
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TE2; ARD1; NATD; ARD1A; ARD1P; OGDNS; hARD1; DXS707; MCOPS1
    Summary
    N-alpha-acetylation is among the most common post-translational protein modifications in eukaryotic cells. This process involves the transfer of an acetyl group from acetyl-coenzyme A to the alpha-amino group on a nascent polypeptide and is essential for normal cell function. This gene encodes an N-terminal acetyltransferase that functions as the catalytic subunit of the major amino-terminal acetyltransferase A complex. Mutations in this gene are the cause of Ogden syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
    Expression
    Ubiquitous expression in fat (RPKM 16.8), appendix (RPKM 16.4) and 25 other tissues See more
    Orthologs
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    Genomic context

    See NAA10 in Genome Data Viewer
    Location:
    Xq28
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (153929225..153935037, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (153194678..153200490, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene arginine vasopressin receptor 2 Neighboring gene Rho GTPase activating protein 4 Neighboring gene renin binding protein Neighboring gene host cell factor C1 Neighboring gene HCFC1 antisense RNA 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ78896, MGC71248

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    part_of NatA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of NatA complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in membrane HDA PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    N-alpha-acetyltransferase 10
    Names
    ARD1 homolog A, N-acetyltransferase
    N-acetyltransferase ARD1, human homolog of
    N-terminal acetyltransferase complex ARD1 subunit homolog A
    arrest defective protein 1
    natA catalytic subunit Naa10
    NP_001243048.1
    NP_001243049.1
    NP_003482.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_031987.1 RefSeqGene

      Range
      5118..10930
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001256119.2NP_001243048.1  N-alpha-acetyltransferase 10 isoform 2

      See identical proteins and their annotated locations for NP_001243048.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AY183135, CA313208, CR979270, U52112
      Consensus CDS
      CCDS59179.1
      UniProtKB/Swiss-Prot
      P41227
      Related
      ENSP00000359026.1, ENST00000370009.5
      Conserved Domains (1) summary
      COG0456
      Location:1134
      RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
    2. NM_001256120.2NP_001243049.1  N-alpha-acetyltransferase 10 isoform 3

      See identical proteins and their annotated locations for NP_001243049.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the central coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AK315997, AY183135, BI192945, CA313208, CR979270, U52112
      UniProtKB/TrEMBL
      B7Z9N2
      Conserved Domains (1) summary
      COG0456
      Location:1143
      RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
    3. NM_003491.4NP_003482.1  N-alpha-acetyltransferase 10 isoform 1

      See identical proteins and their annotated locations for NP_003482.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      BC000308, CA313208, CR979270, U52112
      Consensus CDS
      CCDS14737.1
      UniProtKB/Swiss-Prot
      P41227
      Related
      ENSP00000417763.1, ENST00000464845.6
      Conserved Domains (1) summary
      COG0456
      Location:1149
      RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

      Range
      153929225..153935037 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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