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    ZNF419 zinc finger protein 419 [ Homo sapiens (human) ]

    Gene ID: 79744, updated on 17-Sep-2022

    Summary

    Official Symbol
    ZNF419provided by HGNC
    Official Full Name
    zinc finger protein 419provided by HGNC
    Primary source
    HGNC:HGNC:20648
    See related
    Ensembl:ENSG00000105136 MIM:617410; AllianceGenome:HGNC:20648
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZAPHIR; ZNF419A
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thyroid (RPKM 5.2), spleen (RPKM 4.2) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ZNF419 in Genome Data Viewer
    Location:
    19q13.43
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (57487750..57496098)
    110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (60584812..60593144)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (57999118..58007466)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene vomeronasal 1 receptor 107 pseudogene Neighboring gene zinc finger protein 772 Neighboring gene zinc finger protein 773 Neighboring gene zinc finger protein 549

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ23233

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    zinc finger protein 419
    Names
    zinc finger protein 419A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_054882.1 RefSeqGene

      Range
      5040..13388
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001098491.2NP_001091961.1  zinc finger protein 419 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC003005, AK026886, BC024259, DB004191
      Consensus CDS
      CCDS54325.1
      UniProtKB/Swiss-Prot
      Q96HQ0
      Related
      ENSP00000388864.1, ENST00000424930.6
      Conserved Domains (5) summary
      smart00349
      Location:2888
      KRAB; krueppel associated box
      COG5048
      Location:262418
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:262282
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:2867
      KRAB; KRAB box
      pfam13465
      Location:330355
      zf-H2C2_2; Zinc-finger double domain
    2. NM_001098492.2NP_001091962.1  zinc finger protein 419 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.
      Source sequence(s)
      AC003005, AK026886, BC024259, DC315347
      Consensus CDS
      CCDS54327.1
      UniProtKB/Swiss-Prot
      Q96HQ0
      Related
      ENSP00000390916.1, ENST00000426954.6
      Conserved Domains (5) summary
      smart00349
      Location:1575
      KRAB; krueppel associated box
      COG5048
      Location:249405
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:249269
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:1554
      KRAB; KRAB box
      pfam13465
      Location:317342
      zf-H2C2_2; Zinc-finger double domain
    3. NM_001098493.2NP_001091963.1  zinc finger protein 419 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (4) that is shorter than isoform 1.
      Source sequence(s)
      AC003005, AK026886, BC024259, DC392630
      Consensus CDS
      CCDS54328.1
      UniProtKB/Swiss-Prot
      Q96HQ0
      Related
      ENSP00000414709.2, ENST00000442920.6
      Conserved Domains (5) summary
      smart00349
      Location:1474
      KRAB; krueppel associated box
      COG5048
      Location:248404
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:248268
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:1453
      KRAB; KRAB box
      pfam13465
      Location:316341
      zf-H2C2_2; Zinc-finger double domain
    4. NM_001098494.2NP_001091964.1  zinc finger protein 419 isoform 5

      See identical proteins and their annotated locations for NP_001091964.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (5) that is shorter than isoform 1.
      Source sequence(s)
      AC003005, AK026886, BC024259
      Consensus CDS
      CCDS42637.1
      UniProtKB/Swiss-Prot
      Q96HQ0
      Related
      ENSP00000299860.9, ENST00000347466.10
      Conserved Domains (5) summary
      smart00349
      Location:2869
      KRAB; krueppel associated box
      COG5048
      Location:229385
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:229249
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:2867
      KRAB; KRAB box
      pfam13465
      Location:297322
      zf-H2C2_2; Zinc-finger double domain
    5. NM_001098495.2NP_001091965.1  zinc finger protein 419 isoform 6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks two alternate in-frame exons in the 5' coding region, compared to variant 1, resulting in an isoform (6) that is shorter than isoform 1.
      Source sequence(s)
      AC003005, AK026886, BC024259, BP336834, DC407547
      UniProtKB/Swiss-Prot
      Q96HQ0
      Conserved Domains (5) summary
      smart00349
      Location:1556
      KRAB; krueppel associated box
      COG5048
      Location:216372
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:216236
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:1554
      KRAB; KRAB box
      pfam13465
      Location:284309
      zf-H2C2_2; Zinc-finger double domain
    6. NM_001098496.2NP_001091966.1  zinc finger protein 419 isoform 7

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) lacks two alternate in-frame exons and and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (7) that is shorter than isoform 1.
      Source sequence(s)
      AC003005, AK026886, BC024259, DC315347, DC425209
      Consensus CDS
      CCDS46211.1
      UniProtKB/Swiss-Prot
      Q96HQ0
      Related
      ENSP00000392129.2, ENST00000415379.6
      Conserved Domains (5) summary
      smart00349
      Location:1455
      KRAB; krueppel associated box
      COG5048
      Location:215371
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:215235
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:1453
      KRAB; KRAB box
      pfam13465
      Location:283308
      zf-H2C2_2; Zinc-finger double domain
    7. NM_001291743.2NP_001278672.1  zinc finger protein 419 isoform 8

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) uses an alternate in-frame splice site and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (8) that is shorter than isoform 1.
      Source sequence(s)
      AC003005, AK026886, BC008297, CT002615, DC315347
      UniProtKB/Swiss-Prot
      Q96HQ0
      Conserved Domains (5) summary
      smart00349
      Location:2768
      KRAB; krueppel associated box
      COG5048
      Location:228384
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:228248
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:2766
      KRAB; KRAB box
      pfam13465
      Location:296321
      zf-H2C2_2; Zinc-finger double domain
    8. NM_001291744.2NP_001278673.1  zinc finger protein 419 isoform 9 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) uses an alternate splice site and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, and it also lacks an in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (9) is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AC003005, AK026886, BC008297, DA548110, DC315347
      UniProtKB/Swiss-Prot
      Q96HQ0
      Conserved Domains (3) summary
      COG5048
      Location:173329
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:173193
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:241266
      zf-H2C2_2; Zinc-finger double domain
    9. NM_001291745.2NP_001278674.1  zinc finger protein 419 isoform 10

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10) lacks an alternate in-frame exon in the 5' coding region, and it uses an alternate splice site in its 3' terminal exon and thus differs in the 3' coding region, compared to variant 1. The encoded isoform (10) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      BC008297, BF110540, DC315347
      UniProtKB/Swiss-Prot
      Q96HQ0
      Conserved Domains (2) summary
      smart00349
      Location:1575
      KRAB; krueppel associated box
      pfam01352
      Location:1554
      KRAB; KRAB box
    10. NM_024691.4NP_078967.3  zinc finger protein 419 isoform 2

      See identical proteins and their annotated locations for NP_078967.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
      Source sequence(s)
      AC003005, AK026886, BC024259, BP336834
      Consensus CDS
      CCDS54326.1
      UniProtKB/Swiss-Prot
      Q96HQ0, Q9H5P0
      Related
      ENSP00000221735.7, ENST00000221735.12
      Conserved Domains (5) summary
      smart00349
      Location:2787
      KRAB; krueppel associated box
      COG5048
      Location:261417
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:261281
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:2766
      KRAB; KRAB box
      pfam13465
      Location:329354
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      57487750..57496098
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      60584812..60593144
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)