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    ZBBX zinc finger B-box domain containing [ Homo sapiens (human) ]

    Gene ID: 79740, updated on 11-Jun-2021

    Summary

    Official Symbol
    ZBBXprovided by HGNC
    Official Full Name
    zinc finger B-box domain containingprovided by HGNC
    Primary source
    HGNC:HGNC:26245
    See related
    Ensembl:ENSG00000169064
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Restricted expression toward testis (RPKM 11.7) See more
    Orthologs
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    Genomic context

    See ZBBX in Genome Data Viewer
    Location:
    3q26.1
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (167178399..167407886, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (166957631..167125674, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374196 Neighboring gene peptidylprolyl isomerase A pseudogene 74 Neighboring gene long intergenic non-protein coding RNA 1327 Neighboring gene uncharacterized LOC105374197 Neighboring gene serpin family I member 2 Neighboring gene WD repeat domain 49

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ23049

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cilium movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in motile cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    zinc finger B-box domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199201.2NP_001186130.1  zinc finger B-box domain-containing protein 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC107311, AC117463, BC034229, BC144444, CB321707, DA590037, DB078376
      Consensus CDS
      CCDS56296.1
      UniProtKB/TrEMBL
      B7ZMD2
      Related
      ENSP00000502603.1, ENST00000675490.1
      Conserved Domains (1) summary
      smart00336
      Location:133175
      BBOX; B-Box-type zinc finger
    2. NM_001199202.2NP_001186131.1  zinc finger B-box domain-containing protein 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an exon in the 5' UTR and has an additional exon in the 5' coding region which results in a downstream AUG start codon, as compared to variant 1. The resulting isoform (3) is shorter at the N-terminus, as compared to isoform 1.
      Source sequence(s)
      AC107311, AC117463, BC034229, BC144444, CB321707, DA590037
      Consensus CDS
      CCDS56295.1
      UniProtKB/TrEMBL
      B7ZMD2
      Related
      ENSP00000376517.1, ENST00000392764.5
      Conserved Domains (1) summary
      smart00336
      Location:104146
      BBOX; B-Box-type zinc finger
    3. NM_001377489.1NP_001364418.1  zinc finger B-box domain-containing protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC107311, AC117463
      Related
      ENSP00000390232.3, ENST00000455345.7
      Conserved Domains (1) summary
      cd19818
      Location:133175
      Bbox1_ZBBX; B-box-type 1 zinc finger found in zinc finger B-box domain-containing protein 1 (ZBBX) and similar proteins
    4. NM_024687.4NP_078963.2  zinc finger B-box domain-containing protein 1 isoform 2

      See identical proteins and their annotated locations for NP_078963.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the CDS, as compared to variant 1. The resulting isoform (2) lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      AC107311, AC117463, AK093296, BC034229, CB321707, DA590037, DB078376
      Consensus CDS
      CCDS3199.2
      UniProtKB/Swiss-Prot
      A8MT70
      Related
      ENSP00000376519.2, ENST00000392766.6
      Conserved Domains (1) summary
      cd19818
      Location:133175
      Bbox1_ZBBX; B-box-type 1 zinc finger found in zinc finger B-box domain-containing protein 1 (ZBBX) and similar proteins

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

      Range
      167178399..167407886 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024453753.1XP_024309521.1  zinc finger B-box domain-containing protein 1 isoform X9

      Conserved Domains (2) summary
      smart00336
      Location:133175
      BBOX; B-Box-type zinc finger
      cl08315
      Location:456559
      CAP_GLY; CAP-Gly domain
    2. XM_011513151.3XP_011511453.2  zinc finger B-box domain-containing protein 1 isoform X8

    3. XM_011513145.3XP_011511447.2  zinc finger B-box domain-containing protein 1 isoform X1

    4. XM_011513148.2XP_011511450.2  zinc finger B-box domain-containing protein 1 isoform X2

    5. XM_017007188.1XP_016862677.1  zinc finger B-box domain-containing protein 1 isoform X6

    6. XM_017007187.1XP_016862676.1  zinc finger B-box domain-containing protein 1 isoform X3

    7. XM_017007186.1XP_016862675.1  zinc finger B-box domain-containing protein 1 isoform X1

    8. XM_011513149.2XP_011511451.2  zinc finger B-box domain-containing protein 1 isoform X5

    9. XM_011513152.2XP_011511454.2  zinc finger B-box domain-containing protein 1 isoform X10

    10. XM_011513153.2XP_011511455.2  zinc finger B-box domain-containing protein 1 isoform X11

    11. XM_017007189.2XP_016862678.1  zinc finger B-box domain-containing protein 1 isoform X7

      UniProtKB/Swiss-Prot
      A8MT70
      Conserved Domains (1) summary
      cd19818
      Location:133175
      Bbox1_ZBBX; B-box-type 1 zinc finger found in zinc finger B-box domain-containing protein 1 (ZBBX) and similar proteins
    12. XM_011513144.1XP_011511446.1  zinc finger B-box domain-containing protein 1 isoform X4

      See identical proteins and their annotated locations for XP_011511446.1

      Conserved Domains (1) summary
      smart00336
      Location:133175
      BBOX; B-Box-type zinc finger
    13. XM_011513156.1XP_011511458.1  zinc finger B-box domain-containing protein 1 isoform X12

      See identical proteins and their annotated locations for XP_011511458.1

      Related
      ENSP00000502279.1, ENST00000674903.1
      Conserved Domains (1) summary
      smart00336
      Location:133175
      BBOX; B-Box-type zinc finger
    14. XM_011513155.1XP_011511457.1  zinc finger B-box domain-containing protein 1 isoform X12

      See identical proteins and their annotated locations for XP_011511457.1

      Conserved Domains (1) summary
      smart00336
      Location:133175
      BBOX; B-Box-type zinc finger

    RNA

    1. XR_924174.2 RNA Sequence

    2. XR_001740269.1 RNA Sequence

    3. XR_924172.1 RNA Sequence

    4. XR_924173.1 RNA Sequence

    5. XR_924177.2 RNA Sequence

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