VPS37B VPS37B subunit of ESCRT-I [Homo sapiens (human)] - Gene

Summary

Official Symbol: VPS37Bprovided by HGNC
Official Full Name: VPS37B subunit of ESCRT-Iprovided by HGNC
Primary source: HGNC:HGNC:25754
See related: Ensembl:ENSG00000139722 MIM:610037; AllianceGenome:HGNC:25754
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: Enables calcium-dependent protein binding activity. Involved in positive regulation of viral budding via host ESCRT complex. Located in endosome membrane; midbody; and plasma membrane. Part of ESCRT I complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in esophagus (RPKM 9.2), colon (RPKM 9.0) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 12q24.31

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (122865330..122896124, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (122860577..122891354, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (123349877..123380671, complement)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

VPS37B and appeared to interact with ALG-2 in a stronger manner than TSG101 does.
Title: VPS37 isoforms differentially modulate the ternary complex formation of ALIX, ALG-2, and ESCRT-I.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Pr55(Gag)	gag	Tsg 101, VPS 28, and VPS 37B form the human endosomal sorting complex required for transport (ESCRT-I), which is required for HIV-1 Gag budding and virus infectivity	PubMed
nucleocapsid	gag	GST-fused NCp6 fragment binds ESCRT-I subunits such as MVB12B, VPS37B, VPS28, and TSG101	PubMed
	gag	ESCRT-I complexes contain three common subunits (TSG101, VPS28, and VPS37), and a fourth subunit MVB12. Recombinant ESCRT-I complexes bind HIV-1 p6	PubMed
p6	gag	GST-fused NCp6 fragment binds ESCRT-I subunits such as MVB12B, VPS37B, VPS28, and TSG101	PubMed
	gag	ESCRT-I complexes contain three common subunits (TSG101, VPS28, and VPS37), and a fourth subunit MVB12. Recombinant ESCRT-I complexes bind HIV-1 p6	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BCD1833 (e-PCR)
- UniSTS:18757

RH98647 (e-PCR)
- UniSTS:84296

RH80051 (e-PCR)
- UniSTS:85226

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables calcium-dependent protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in macroautophagy	TAS Traceable Author Statement more info	PubMed
involved_in membrane fission	NAS Non-traceable Author Statement more info	PubMed
involved_in multivesicular body assembly	NAS Non-traceable Author Statement more info	PubMed
involved_in multivesicular body assembly	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of viral budding via host ESCRT complex	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein targeting to membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein targeting to vacuole	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in viral budding via host ESCRT complex	TAS Traceable Author Statement more info	PubMed
involved_in viral release from host cell	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of ESCRT I complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ESCRT I complex	IDA Inferred from Direct Assay more info	PubMed
part_of ESCRT I complex	IPI Inferred from Physical Interaction more info	PubMed
part_of ESCRT I complex	TAS Traceable Author Statement more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in endosome membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endosome membrane	NAS Non-traceable Author Statement more info	PubMed
located_in endosome membrane	TAS Traceable Author Statement more info
located_in extracellular exosome	HDA more info	PubMed
located_in late endosome membrane	IEA Inferred from Electronic Annotation more info
located_in midbody	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: vacuolar protein sorting-associated protein 37B

Names: ESCRT-I complex subunit VPS37B; VPS37B, ESCRT-I subunit; hVps37B; vacuolar protein sorting 37 homolog B; vacuolar protein sorting 37B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_024667.3 → NP_078943.1 vacuolar protein sorting-associated protein 37B

See identical proteins and their annotated locations for NP_078943.1

Status: VALIDATED

Source sequence(s)

AK022812, BU629695

Consensus CDS

CCDS9239.1

UniProtKB/Swiss-Prot

Q9H9H4

UniProtKB/TrEMBL

F5H4M0

Related

ENSP00000267202.2, ENST00000267202.7

Conserved Domains (1) summary

pfam07200
Location:11 → 156

Mod_r; Modifier of rudimentary (Mod(r)) protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000012.12 Reference GRCh38.p14 Primary Assembly

Range

122865330..122896124 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011538743.3 → XP_011537045.1 vacuolar protein sorting-associated protein 37B isoform X1

Conserved Domains (1) summary

pfam07200
Location:96 → 211

Mod_r; Modifier of rudimentary (Mod(r)) protein
XM_011538745.3 → XP_011537047.1 vacuolar protein sorting-associated protein 37B isoform X2

UniProtKB/TrEMBL

F5H4M0

Conserved Domains (1) summary

pfam07200
Location:20 → 134

Mod_r; Modifier of rudimentary (Mod(r)) protein
XM_047429550.1 → XP_047285506.1 vacuolar protein sorting-associated protein 37B isoform X3
XM_006719602.5 → XP_006719665.1 vacuolar protein sorting-associated protein 37B isoform X3

See identical proteins and their annotated locations for XP_006719665.1

UniProtKB/TrEMBL

F5H4M0

Conserved Domains (1) summary

pfam07200
Location:10 → 124

Mod_r; Modifier of rudimentary (Mod(r)) protein
XM_017019971.2 → XP_016875460.1 vacuolar protein sorting-associated protein 37B isoform X4

Alternate T2T-CHM13v2.0

Genomic

NC_060936.1 Alternate T2T-CHM13v2.0

Range

122860577..122891354 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054373237.1 → XP_054229212.1 vacuolar protein sorting-associated protein 37B isoform X1
XM_054373238.1 → XP_054229213.1 vacuolar protein sorting-associated protein 37B isoform X2
XM_054373239.1 → XP_054229214.1 vacuolar protein sorting-associated protein 37B isoform X3
XM_054373240.1 → XP_054229215.1 vacuolar protein sorting-associated protein 37B isoform X3
XM_054373241.1 → XP_054229216.1 vacuolar protein sorting-associated protein 37B isoform X3
XM_054373242.1 → XP_054229217.1 vacuolar protein sorting-associated protein 37B isoform X4