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    AUNIP aurora kinase A and ninein interacting protein [ Homo sapiens (human) ]

    Gene ID: 79000, updated on 5-Aug-2022

    Summary

    Official Symbol
    AUNIPprovided by HGNC
    Official Full Name
    aurora kinase A and ninein interacting proteinprovided by HGNC
    Primary source
    HGNC:HGNC:28363
    See related
    Ensembl:ENSG00000127423 AllianceGenome:HGNC:28363
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AIBP; C1orf135
    Summary
    Enables damaged DNA binding activity. Involved in double-strand break repair via homologous recombination; negative regulation of double-strand break repair via nonhomologous end joining; and spindle organization. Located in centrosome; site of DNA damage; and spindle pole. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis (RPKM 11.8), adrenal (RPKM 7.3) and 24 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See AUNIP in Genome Data Viewer
    Location:
    1p36.11
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (25831906..25859457, complement)
    110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (25669339..25696890, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (26158397..26185948, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene selenoprotein N Neighboring gene uncharacterized LOC646471 Neighboring gene mitochondrial fission regulator 1 like Neighboring gene progestin and adipoQ receptor family member 7 Neighboring gene stathmin 1 Neighboring gene small nuclear ribonucleoprotein polypeptide F pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC2603, FLJ14264

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables damaged DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in site of DNA damage IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in spindle pole IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    aurora kinase A and ninein-interacting protein
    Names
    aurora A-binding protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001287490.2NP_001274419.1  aurora kinase A and ninein-interacting protein isoform 1

      See identical proteins and their annotated locations for NP_001274419.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AL020996, BF987554, BJ989876, GQ844687
      Consensus CDS
      CCDS72731.1
      UniProtKB/Swiss-Prot
      Q9H7T9
      Related
      ENSP00000443647.1, ENST00000538789.5
      Conserved Domains (1) summary
      pfam15334
      Location:26348
      AIB; Aurora kinase A and ninein interacting protein
    2. NM_024037.3NP_076942.1  aurora kinase A and ninein-interacting protein isoform 2

      See identical proteins and their annotated locations for NP_076942.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 3' terminal exon, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AI198661, AL020996, BC000209, BJ989876
      Consensus CDS
      CCDS266.1
      UniProtKB/Swiss-Prot
      Q53F70, Q9H7T9
      Related
      ENSP00000363416.4, ENST00000374298.4
      Conserved Domains (1) summary
      pfam15334
      Location:26350
      AIB; Aurora kinase A and ninein interacting protein

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      25831906..25859457 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047430116.1XP_047286072.1  aurora kinase A and ninein-interacting protein isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      25669339..25696890 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)