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    Clasp2 CLIP associating protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 76499, updated on 8-Apr-2018
    Official Symbol
    Clasp2provided by MGI
    Official Full Name
    CLIP associating protein 2provided by MGI
    Primary source
    MGI:MGI:1923749
    See related
    Ensembl:ENSMUSG00000033392 Vega:OTTMUSG00000062438
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C77448; mKIAA0627; CLASP2beta; 1500004F14Rik; 8030404L10Rik
    Expression
    Broad expression in CNS E18 (RPKM 23.3), cerebellum adult (RPKM 19.0) and 21 other tissues See more
    Orthologs
    Location:
    9; 9 F3
    Exon count:
    48
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (113741059..113919697)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (113650591..113828815)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene programmed cell death 6 interacting protein Neighboring gene predicted gene, 38623 Neighboring gene uncharacterized LOC108167687 Neighboring gene upstream binding protein 1 Neighboring gene F-box and leucine-rich repeat protein 2

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    actin filament binding ISO
    Inferred from Sequence Orthology
    more info
     
    dystroglycan binding ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule binding ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule plus-end binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    Golgi organization ISO
    Inferred from Sequence Orthology
    more info
     
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    establishment or maintenance of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    exit from mitosis ISO
    Inferred from Sequence Orthology
    more info
     
    meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule anchoring ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule nucleation ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule organizing center organization ISO
    Inferred from Sequence Orthology
    more info
     
    mitotic spindle organization ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of focal adhesion assembly ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of microtubule depolymerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of microtubule depolymerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of microtubule depolymerization ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of wound healing, spreading of epidermal cells ISO
    Inferred from Sequence Orthology
    more info
     
    platelet-derived growth factor receptor-beta signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of basement membrane assembly involved in embryonic body morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of epithelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of exocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of extracellular matrix disassembly ISO
    Inferred from Sequence Orthology
    more info
     
    protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of axon extension ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of gastrulation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of microtubule polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of microtubule polymerization or depolymerization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of microtubule-based process ISO
    Inferred from Sequence Orthology
    more info
     
    vesicle targeting ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    axonal growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    basal cortex ISO
    Inferred from Sequence Orthology
    more info
     
    cell cortex ISO
    Inferred from Sequence Orthology
    more info
     
    cell leading edge IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell leading edge ISO
    Inferred from Sequence Orthology
    more info
     
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
     
    cortical microtubule plus-end ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with cytoplasmic microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasmic microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    ruffle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    CLIP-associating protein 2
    Names
    CLASP2alpha
    CLASP2gamma
    CLIP-associating protein CLASP2
    cytoplasmic linker-associated protein 2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081960.1NP_001075429.1  CLIP-associating protein 2 isoform b

      See identical proteins and their annotated locations for NP_001075429.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 3. It encodes isoform b, which has a shorter and distinct N-terminus, compared to isoform c.
      Source sequence(s)
      AC107803, AK164326, BC117963
      Consensus CDS
      CCDS40787.1
      UniProtKB/TrEMBL
      Q08EB6
      Related
      ENSMUSP00000130201.2, OTTMUSP00000078939, ENSMUST00000166734.9, OTTMUST00000152236
      Conserved Domains (2) summary
      pfam12348
      Location:100311
      CLASP_N; CLASP N terminal
      sd00044
      Location:10571079
      HEAT; HEAT repeat [structural motif]
    2. NM_001114347.1NP_001107819.1  CLIP-associating protein 2 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (c).
      Source sequence(s)
      AC107803, AC167246
      Conserved Domains (2) summary
      pfam12348
      Location:327538
      CLASP_N; CLASP N terminal
      sd00044
      Location:91121
      HEAT; HEAT repeat [structural motif]
    3. NM_001286599.1NP_001273528.1  CLIP-associating protein 2 isoform d

      See identical proteins and their annotated locations for NP_001273528.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 3' UTR, lacks a portion of the 3' coding region, and includes an alternate 3' terminal exon, compared to variant 3. It encodes isoform d, which has a shorter and distinct C-terminus, compared to isoform c.
      Source sequence(s)
      AI529145, AK005146, AK034560
      UniProtKB/Swiss-Prot
      Q8BRT1
      UniProtKB/TrEMBL
      Q8BSE7
      Related
      ENSMUSP00000150741.1, OTTMUSP00000078937, ENSMUST00000216817.1, OTTMUST00000152230
      Conserved Domains (2) summary
      pfam12348
      Location:80197
      CLASP_N; CLASP N terminal
      sd00044
      Location:91121
      HEAT; HEAT repeat [structural motif]
    4. NM_001286600.1NP_001273529.1  CLIP-associating protein 2 isoform e

      See identical proteins and their annotated locations for NP_001273529.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' and 3' coding region, and initiates translation at an alternate start codon, compared to variant 3. It encodes isoform e, which is shorter and has a distinct N-terminus, compared to isoform c.
      Source sequence(s)
      AC107803, AK043551, AK148966
      UniProtKB/Swiss-Prot
      Q8BRT1
      UniProtKB/TrEMBL
      Q08EB5, Q3UF57
      Related
      ENSMUSP00000149670.1, OTTMUSP00000078941, ENSMUST00000214522.1, OTTMUST00000152238
      Conserved Domains (2) summary
      pfam12348
      Location:100311
      CLASP_N; CLASP N terminal
      sd00044
      Location:10741096
      HEAT; HEAT repeat [structural motif]
    5. NM_001286601.1NP_001273530.1  CLIP-associating protein 2 isoform f

      See identical proteins and their annotated locations for NP_001273530.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' and 3' coding region, and initiates translation at an alternate start codon, compared to variant 3. It encodes isoform f, which is shorter and has a distinct N-terminus, compared to isoform c.
      Source sequence(s)
      AC107803, AK043551, AK164326
      UniProtKB/Swiss-Prot
      Q8BRT1
      UniProtKB/TrEMBL
      A2RRR3
      Conserved Domains (2) summary
      pfam12348
      Location:2113
      CLASP_N; CLASP N terminal
      sd00044
      Location:859881
      HEAT; HEAT repeat [structural motif]
    6. NM_001286602.1NP_001273531.1  CLIP-associating protein 2 isoform g

      See identical proteins and their annotated locations for NP_001273531.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR, lacks a portion of the 5' and 3' coding region, and initiates translation at an alternate start codon, compared to variant 3. It encodes isoform g, which is shorter and has a distinct N-terminus, compared to isoform c.
      Source sequence(s)
      AC107803, AK043551, AK164326
      UniProtKB/Swiss-Prot
      Q8BRT1
      UniProtKB/TrEMBL
      B9EJA4
      Related
      ENSMUSP00000128460.2, OTTMUSP00000078942, ENSMUST00000163895.2, OTTMUST00000152239
      Conserved Domains (3) summary
      pfam10265
      Location:459579
      DUF2217; Uncharacterized conserved protein (DUF2217)
      pfam12348
      Location:100311
      CLASP_N; CLASP N terminal
      sd00044
      Location:10781100
      HEAT; HEAT repeat [structural motif]
    7. NM_001286603.1NP_001273532.1  CLIP-associating protein 2 isoform h

      See identical proteins and their annotated locations for NP_001273532.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in both UTR's and the coding region but maintains the reading frame, compared to variant 3. This results in a protein (isoform h) that is shorter at both the N- and C-termini, compared to isoform c.
      Source sequence(s)
      AK005146, BC030468, CJ052159
      UniProtKB/Swiss-Prot
      Q8BRT1
      Conserved Domains (1) summary
      PLN02577
      Location:62156
      PLN02577; hydroxymethylglutaryl-CoA synthase
    8. NM_029633.2NP_083909.2  CLIP-associating protein 2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR, lacks a portion of the 5' and 3' coding region, and initiates translation at an alternate start codon, compared to variant 3. It encodes isoform a, which is shorter and has a distinct N-terminus, compared to isoform c.
      Source sequence(s)
      AC107803, AK164326, BC117963
      Consensus CDS
      CCDS52948.1
      UniProtKB/TrEMBL
      E9Q8N5, Q08EB6
      Related
      ENSMUSP00000107469.2, OTTMUSP00000078938, ENSMUST00000111838.9, OTTMUST00000152235
      Conserved Domains (2) summary
      pfam12348
      Location:100311
      CLASP_N; CLASP N terminal
      sd00044
      Location:10561078
      HEAT; HEAT repeat [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      113741059..113919697
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017313687.1XP_017169176.1  CLIP-associating protein 2 isoform X15

    2. XM_006512384.3XP_006512447.1  CLIP-associating protein 2 isoform X1

      Conserved Domains (3) summary
      pfam10265
      Location:714824
      DUF2217; Uncharacterized conserved protein (DUF2217)
      pfam12348
      Location:327538
      CLASP_N; CLASP N terminal
      sd00044
      Location:91121
      HEAT; HEAT repeat [structural motif]
    3. XM_006512385.3XP_006512448.1  CLIP-associating protein 2 isoform X2

      Conserved Domains (3) summary
      pfam10265
      Location:714824
      DUF2217; Uncharacterized conserved protein (DUF2217)
      pfam12348
      Location:327538
      CLASP_N; CLASP N terminal
      sd00044
      Location:91121
      HEAT; HEAT repeat [structural motif]
    4. XM_006512387.3XP_006512450.1  CLIP-associating protein 2 isoform X4

      Conserved Domains (3) summary
      pfam10265
      Location:714824
      DUF2217; Uncharacterized conserved protein (DUF2217)
      pfam12348
      Location:327538
      CLASP_N; CLASP N terminal
      sd00044
      Location:91121
      HEAT; HEAT repeat [structural motif]
    5. XM_006512391.3XP_006512454.1  CLIP-associating protein 2 isoform X8

      Conserved Domains (2) summary
      pfam12348
      Location:327538
      CLASP_N; CLASP N terminal
      sd00044
      Location:91121
      HEAT; HEAT repeat [structural motif]
    6. XM_006512392.3XP_006512455.1  CLIP-associating protein 2 isoform X9

      Conserved Domains (2) summary
      pfam12348
      Location:327538
      CLASP_N; CLASP N terminal
      sd00044
      Location:91121
      HEAT; HEAT repeat [structural motif]
    7. XM_006512390.3XP_006512453.1  CLIP-associating protein 2 isoform X7

      Conserved Domains (3) summary
      pfam10265
      Location:686806
      DUF2217; Uncharacterized conserved protein (DUF2217)
      pfam12348
      Location:327538
      CLASP_N; CLASP N terminal
      sd00044
      Location:91121
      HEAT; HEAT repeat [structural motif]
    8. XM_006512393.3XP_006512456.1  CLIP-associating protein 2 isoform X11

      Conserved Domains (3) summary
      pfam10265
      Location:686806
      DUF2217; Uncharacterized conserved protein (DUF2217)
      pfam12348
      Location:327538
      CLASP_N; CLASP N terminal
      sd00044
      Location:91121
      HEAT; HEAT repeat [structural motif]
    9. XM_017313686.1XP_017169175.1  CLIP-associating protein 2 isoform X14

    10. XM_006512386.3XP_006512449.1  CLIP-associating protein 2 isoform X3

      Conserved Domains (3) summary
      pfam10265
      Location:708818
      DUF2217; Uncharacterized conserved protein (DUF2217)
      pfam12348
      Location:327538
      CLASP_N; CLASP N terminal
      sd00044
      Location:91121
      HEAT; HEAT repeat [structural motif]
    11. XM_017313684.1XP_017169173.1  CLIP-associating protein 2 isoform X10

    12. XM_006512388.3XP_006512451.1  CLIP-associating protein 2 isoform X5

      Conserved Domains (3) summary
      pfam10265
      Location:706816
      DUF2217; Uncharacterized conserved protein (DUF2217)
      pfam12348
      Location:327538
      CLASP_N; CLASP N terminal
      sd00044
      Location:91121
      HEAT; HEAT repeat [structural motif]
    13. XM_017313685.1XP_017169174.1  CLIP-associating protein 2 isoform X12

    14. XM_006512389.3XP_006512452.1  CLIP-associating protein 2 isoform X6

      Conserved Domains (3) summary
      pfam10265
      Location:700810
      DUF2217; Uncharacterized conserved protein (DUF2217)
      pfam12348
      Location:327538
      CLASP_N; CLASP N terminal
      sd00044
      Location:91121
      HEAT; HEAT repeat [structural motif]
    15. XM_006512394.3XP_006512457.1  CLIP-associating protein 2 isoform X13

      Conserved Domains (3) summary
      pfam10265
      Location:672792
      DUF2217; Uncharacterized conserved protein (DUF2217)
      pfam12348
      Location:327538
      CLASP_N; CLASP N terminal
      sd00044
      Location:91121
      HEAT; HEAT repeat [structural motif]
    16. XM_006512397.3XP_006512460.1  CLIP-associating protein 2 isoform X22

      Conserved Domains (3) summary
      pfam10265
      Location:672792
      DUF2217; Uncharacterized conserved protein (DUF2217)
      pfam12348
      Location:327538
      CLASP_N; CLASP N terminal
      sd00044
      Location:91121
      HEAT; HEAT repeat [structural motif]
    17. XM_017313690.1XP_017169179.1  CLIP-associating protein 2 isoform X20

    18. XM_006512396.1XP_006512459.1  CLIP-associating protein 2 isoform X17

      Conserved Domains (3) summary
      pfam10265
      Location:481591
      DUF2217; Uncharacterized conserved protein (DUF2217)
      pfam12348
      Location:94305
      CLASP_N; CLASP N terminal
      sd00044
      Location:10901112
      HEAT; HEAT repeat [structural motif]
    19. XM_017313689.1XP_017169178.1  CLIP-associating protein 2 isoform X19

    20. XM_017313691.1XP_017169180.1  CLIP-associating protein 2 isoform X21

    21. XM_006512395.3XP_006512458.1  CLIP-associating protein 2 isoform X16

      Conserved Domains (3) summary
      pfam10265
      Location:487597
      DUF2217; Uncharacterized conserved protein (DUF2217)
      pfam12348
      Location:100311
      CLASP_N; CLASP N terminal
      sd00044
      Location:10961118
      HEAT; HEAT repeat [structural motif]
    22. XM_017313688.1XP_017169177.1  CLIP-associating protein 2 isoform X18

    RNA

    1. XR_379881.3 RNA Sequence

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