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    YES1 YES proto-oncogene 1, Src family tyrosine kinase [ Homo sapiens (human) ]

    Gene ID: 7525, updated on 15-Apr-2019

    Summary

    Official Symbol
    YES1provided by HGNC
    Official Full Name
    YES proto-oncogene 1, Src family tyrosine kinaseprovided by HGNC
    Primary source
    HGNC:HGNC:12841
    See related
    Ensembl:ENSG00000176105 MIM:164880
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Yes; c-yes; HsT441; P61-YES
    Summary
    This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in placenta (RPKM 22.4), fat (RPKM 16.6) and 25 other tissues See more
    Orthologs

    Genomic context

    See YES1 in Genome Data Viewer
    Location:
    18p11.32
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 18 NC_000018.10 (721592..812846, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (721592..812327, complement)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene clusterin like 1 Neighboring gene TYMS opposite strand Neighboring gene thymidylate synthetase Neighboring gene enolase superfamily member 1 Neighboring gene RNA, U1 small nuclear 109, pseudogene Neighboring gene bolA family member 2 pseudogene 1 Neighboring gene proteasome 26S subunit, non-ATPase 8 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
    NHGRI GWA Catalog
    Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients.
    NHGRI GWA Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat downregulates the expression of v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 (YES1) in human primary T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    epidermal growth factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    ion channel binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    non-membrane spanning protein tyrosine kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    phosphotyrosine residue binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein tyrosine kinase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    protein tyrosine kinase activity TAS
    Traceable Author Statement
    more info
     
    signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    Fc-gamma receptor signaling pathway involved in phagocytosis TAS
    Traceable Author Statement
    more info
     
    T cell costimulation TAS
    Traceable Author Statement
    more info
     
    cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular protein modification process TAS
    Traceable Author Statement
    more info
    PubMed 
    cellular response to platelet-derived growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to retinoic acid IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to transforming growth factor beta stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    ephrin receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    leukocyte migration TAS
    Traceable Author Statement
    more info
     
    peptidyl-tyrosine autophosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of glucose transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of vascular permeability TAS
    Traceable Author Statement
    more info
    PubMed 
    transmembrane receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    actin filament IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    extracellular exosome HDA PubMed 
    extrinsic component of cytoplasmic side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    focal adhesion HDA PubMed 
    glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule organizing center IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynaptic specialization, intracellular component IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    tyrosine-protein kinase Yes
    Names
    YES1 proto-oncogene, Src family tyrosine kinase
    Yamaguchi sarcoma oncogene
    cellular yes-1 protein
    proto-oncogene c-Yes
    proto-oncogene tyrosine-protein kinase YES
    v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
    NP_005424.1
    XP_005258196.1
    XP_016881449.1
    XP_024307011.1
    XP_024307012.1
    XP_024307013.1
    XP_024307014.1
    XP_024307015.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005433.4NP_005424.1  tyrosine-protein kinase Yes

      See identical proteins and their annotated locations for NP_005424.1

      Status: REVIEWED

      Source sequence(s)
      AP000894, AP001020, AP001178
      Consensus CDS
      CCDS11824.1
      UniProtKB/Swiss-Prot
      P07947
      Related
      ENSP00000324740.4, ENST00000314574.5
      Conserved Domains (3) summary
      cd09933
      Location:154253
      SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
      cd12007
      Location:94151
      SH3_Yes; Src homology 3 domain of Yes Protein Tyrosine Kinase
      cd05069
      Location:264542
      PTKc_Yes; Catalytic domain of the Protein Tyrosine Kinase, Yes

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p12 Primary Assembly

      Range
      721592..812846 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024451244.1XP_024307012.1  tyrosine-protein kinase Yes isoform X1

      Conserved Domains (3) summary
      cd09933
      Location:154253
      SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
      cd12007
      Location:94151
      SH3_Yes; Src homology 3 domain of Yes Protein Tyrosine Kinase
      cd05069
      Location:264542
      PTKc_Yes; Catalytic domain of the Protein Tyrosine Kinase, Yes
    2. XM_024451243.1XP_024307011.1  tyrosine-protein kinase Yes isoform X1

      Related
      ENSP00000462468.1, ENST00000584307.5
      Conserved Domains (3) summary
      cd09933
      Location:154253
      SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
      cd12007
      Location:94151
      SH3_Yes; Src homology 3 domain of Yes Protein Tyrosine Kinase
      cd05069
      Location:264542
      PTKc_Yes; Catalytic domain of the Protein Tyrosine Kinase, Yes
    3. XM_024451247.1XP_024307015.1  tyrosine-protein kinase Yes isoform X2

      Conserved Domains (3) summary
      cd09933
      Location:154253
      SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
      cd12007
      Location:94151
      SH3_Yes; Src homology 3 domain of Yes Protein Tyrosine Kinase
      cl21453
      Location:264498
      PKc_like; Protein Kinases, catalytic domain
    4. XM_024451246.1XP_024307014.1  tyrosine-protein kinase Yes isoform X1

      Conserved Domains (3) summary
      cd09933
      Location:154253
      SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
      cd12007
      Location:94151
      SH3_Yes; Src homology 3 domain of Yes Protein Tyrosine Kinase
      cd05069
      Location:264542
      PTKc_Yes; Catalytic domain of the Protein Tyrosine Kinase, Yes
    5. XM_005258139.4XP_005258196.1  tyrosine-protein kinase Yes isoform X2

      See identical proteins and their annotated locations for XP_005258196.1

      Conserved Domains (3) summary
      cd09933
      Location:154253
      SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
      cd12007
      Location:94151
      SH3_Yes; Src homology 3 domain of Yes Protein Tyrosine Kinase
      cl21453
      Location:264498
      PKc_like; Protein Kinases, catalytic domain
    6. XM_017025960.2XP_016881449.1  tyrosine-protein kinase Yes isoform X1

      UniProtKB/Swiss-Prot
      P07947
      Conserved Domains (3) summary
      cd09933
      Location:154253
      SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
      cd12007
      Location:94151
      SH3_Yes; Src homology 3 domain of Yes Protein Tyrosine Kinase
      cd05069
      Location:264542
      PTKc_Yes; Catalytic domain of the Protein Tyrosine Kinase, Yes
    7. XM_024451245.1XP_024307013.1  tyrosine-protein kinase Yes isoform X1

      Related
      ENSP00000464380.1, ENST00000577961.5
      Conserved Domains (3) summary
      cd09933
      Location:154253
      SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
      cd12007
      Location:94151
      SH3_Yes; Src homology 3 domain of Yes Protein Tyrosine Kinase
      cd05069
      Location:264542
      PTKc_Yes; Catalytic domain of the Protein Tyrosine Kinase, Yes
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