Format

Send to:

Choose Destination
    • Showing Current items.

    Usp47 ubiquitin specific peptidase 47 [ Mus musculus (house mouse) ]

    Gene ID: 74996, updated on 9-Sep-2018

    Summary

    Official Symbol
    Usp47provided by MGI
    Official Full Name
    ubiquitin specific peptidase 47provided by MGI
    Primary source
    MGI:MGI:1922246
    See related
    Ensembl:ENSMUSG00000059263 Vega:OTTMUSG00000060217
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4930502N04Rik; A630020C16Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 27.4), testis adult (RPKM 27.0) and 28 other tissues See more
    Orthologs

    Genomic context

    See Usp47 in Genome Data Viewer
    Location:
    7; 7 F1
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (112023483..112111386)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (119167020..119254894)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene putative high mobility group protein B1-like 1 Neighboring gene predicted gene, 33204 Neighboring gene predicted gene 3960 Neighboring gene dickkopf WNT signaling pathway inhibitor 3 Neighboring gene predicted gene, 39071

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (2) 
    • Targeted (1) 
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC118655

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    WD40-repeat domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    thiol-dependent ubiquitin-specific protease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    thiol-dependent ubiquitin-specific protease activity ISO
    Inferred from Sequence Orthology
    more info
     
    thiol-dependent ubiquitinyl hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitinyl hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    base-excision repair ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to UV IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    monoubiquitinated protein deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of G2/M transition of mitotic cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell growth ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    protein deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of protein stability IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to drug ISO
    Inferred from Sequence Orthology
    more info
     
    response to drug ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    SCF ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    SCF ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 47
    Names
    deubiquitinating enzyme 47
    ubiquitin specific protease 47
    ubiquitin thioesterase 47
    ubiquitin thiolesterase 47
    ubiquitin-specific-processing protease 47
    NP_598519.2
    NP_796223.2
    XP_006508336.1
    XP_006508337.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357952.1NP_001344881.1  ubiquitin carboxyl-terminal hydrolase 47 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) encodes isoform 3. Variants 1 and 3 encode protein isoforms of identical length but with distinct amino acid sequences.
      Source sequence(s)
      AC122343
      Conserved Domains (1) summary
      cd02659
      Location:166566
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    2. NM_133758.3NP_598519.2  ubiquitin carboxyl-terminal hydrolase 47 isoform 2

      See identical proteins and their annotated locations for NP_598519.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region, compared to variant 1, which results in a shorter isoform (2), compared to isoform 1.
      Source sequence(s)
      AK041541, AK131138, BC089364, BY160489, CO042533
      Consensus CDS
      CCDS40089.1
      UniProtKB/Swiss-Prot
      Q8BY87
      Related
      ENSMUSP00000102264.2, OTTMUSP00000076701, ENSMUST00000106653.3, OTTMUST00000147392
      Conserved Domains (2) summary
      cd02659
      Location:166546
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:167541
      UCH; Ubiquitin carboxyl-terminal hydrolase
    3. NM_177249.3NP_796223.2  ubiquitin carboxyl-terminal hydrolase 47 isoform 1

      See identical proteins and their annotated locations for NP_796223.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1. Variants 1 and 3 encode protein isoforms of identical length but with distinct amino acid sequences.
      Source sequence(s)
      AK041541, AK082114, AK131138, BC089364, BY160489, CO042533
      Consensus CDS
      CCDS85384.1
      UniProtKB/Swiss-Prot
      Q8BY87
      Related
      ENSMUSP00000147619.1, OTTMUSP00000076702, ENSMUST00000210309.1, OTTMUST00000147394
      Conserved Domains (2) summary
      cd02659
      Location:186566
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:187561
      UCH; Ubiquitin carboxyl-terminal hydrolase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      112023483..112111386
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508273.3XP_006508336.1  ubiquitin carboxyl-terminal hydrolase 47 isoform X1

      Conserved Domains (2) summary
      cd02659
      Location:186586
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:187581
      UCH; Ubiquitin carboxyl-terminal hydrolase
    2. XM_006508274.3XP_006508337.1  ubiquitin carboxyl-terminal hydrolase 47 isoform X2

      UniProtKB/TrEMBL
      A0A1L1SV73
      Related
      ENSMUSP00000151051.1, OTTMUSP00000078844, ENSMUST00000215510.1, OTTMUST00000152059
      Conserved Domains (1) summary
      cd02659
      Location:166566
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    Support Center