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    Atp13a2 ATPase type 13A2 [ Mus musculus (house mouse) ]

    Gene ID: 74772, updated on 17-Jul-2018

    Summary

    Official Symbol
    Atp13a2provided by MGI
    Official Full Name
    ATPase type 13A2provided by MGI
    Primary source
    MGI:MGI:1922022
    See related
    Ensembl:ENSMUSG00000036622 Vega:OTTMUSG00000010089
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AA589443; 1110012E06Rik
    Expression
    Ubiquitous expression in spleen adult (RPKM 76.5), ovary adult (RPKM 68.9) and 28 other tissues See more
    Orthologs

    Genomic context

    See Atp13a2 in Genome Data Viewer
    Location:
    4; 4 D3
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (140986861..141007701)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (140542788..140563616)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene peptidyl arginine deiminase, type II Neighboring gene predicted gene 13031 Neighboring gene predicted gene, 34431 Neighboring gene succinate dehydrogenase complex, subunit B, iron sulfur (Ip) Neighboring gene microfibrillar-associated protein 2 Neighboring gene ciliary rootlet coiled-coil, rootletin

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidic acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylinositol-3,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    autophagosome organization ISO
    Inferred from Sequence Orthology
    more info
     
    cation transport IEA
    Inferred from Electronic Annotation
    more info
     
    cellular calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    cellular iron ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to manganese ion ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    cellular zinc ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome biogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-aspartic acid autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    polyamine transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of exosomal secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of exosomal secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of autophagosome size ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of glucosylceramidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of intracellular protein transport NAS
    Non-traceable Author Statement
    more info
    PubMed 
    regulation of lysosomal protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of lysosomal protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of macroautophagy ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
     
    zinc ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    zinc ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    autophagosome ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    late endosome ISO
    Inferred from Sequence Orthology
    more info
     
    lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    multivesicular body ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    transport vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    cation-transporting ATPase 13A2; probable cation-transporting ATPase 13A2
    NP_001157838.1
    NP_083373.2
    XP_006539299.1
    XP_006539300.1
    XP_017175913.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164366.1NP_001157838.1  cation-transporting ATPase 13A2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AL645625
      Consensus CDS
      CCDS51345.1
      UniProtKB/TrEMBL
      E9Q2A4
      Related
      ENSMUSP00000132183.1, OTTMUSP00000049173, ENSMUST00000127833.2, OTTMUST00000023465
      Conserved Domains (6) summary
      COG4087
      Location:839888
      COG4087; Soluble P-type ATPase [General function prediction only]
      TIGR01657
      Location:351067
      P-ATPase-V; P-type ATPase of unknown pump specificity (type V)
      pfam00122
      Location:258493
      E1-E2_ATPase; E1-E2 ATPase
      pfam12409
      Location:35161
      P5-ATPase; P5-type ATPase cation transporter
      pfam13246
      Location:621658
      Cation_ATPase; Cation transport ATPase (P-type)
      cl02930
      Location:188260
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    2. NM_029097.2NP_083373.2  cation-transporting ATPase 13A2 isoform 1

      See identical proteins and their annotated locations for NP_083373.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL645625
      Consensus CDS
      CCDS18859.1
      UniProtKB/Swiss-Prot
      Q9CTG6
      Related
      ENSMUSP00000039648.7, OTTMUSP00000010718, ENSMUST00000037055.13, OTTMUST00000023462
      Conserved Domains (6) summary
      COG4087
      Location:839888
      COG4087; Soluble P-type ATPase [General function prediction only]
      TIGR01657
      Location:351112
      P-ATPase-V; P-type ATPase of unknown pump specificity (type V)
      pfam00122
      Location:258493
      E1-E2_ATPase; E1-E2 ATPase
      pfam12409
      Location:35161
      P5-ATPase; P5-type ATPase cation transporter
      pfam13246
      Location:621658
      Cation_ATPase; Cation transport ATPase (P-type)
      cl02930
      Location:188260
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      140986861..141007701
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539236.3XP_006539299.1  probable cation-transporting ATPase 13A2 isoform X1

      Conserved Domains (6) summary
      COG4087
      Location:922971
      COG4087; Soluble P-type ATPase [General function prediction only]
      TIGR01657
      Location:351195
      P-ATPase-V; P-type ATPase of unknown pump specificity (type V)
      pfam00122
      Location:341576
      E1-E2_ATPase; E1-E2 ATPase
      pfam12409
      Location:35110
      P5-ATPase; P5-type ATPase cation transporter
      pfam13246
      Location:704741
      Cation_ATPase; Cation transport ATPase (P-type)
      cl02930
      Location:271343
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    2. XM_006539237.3XP_006539300.1  probable cation-transporting ATPase 13A2 isoform X2

      Related
      ENSMUSP00000126461.1, OTTMUSP00000049172, ENSMUST00000168047.7, OTTMUST00000089892
      Conserved Domains (6) summary
      COG4087
      Location:922971
      COG4087; Soluble P-type ATPase [General function prediction only]
      TIGR01657
      Location:351150
      P-ATPase-V; P-type ATPase of unknown pump specificity (type V)
      pfam00122
      Location:341576
      E1-E2_ATPase; E1-E2 ATPase
      pfam12409
      Location:35110
      P5-ATPase; P5-type ATPase cation transporter
      pfam13246
      Location:704741
      Cation_ATPase; Cation transport ATPase (P-type)
      cl02930
      Location:271343
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    3. XM_017320424.1XP_017175913.1  probable cation-transporting ATPase 13A2 isoform X3

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