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    Xrcc3 X-ray repair complementing defective repair in Chinese hamster cells 3 [ Mus musculus (house mouse) ]

    Gene ID: 74335, updated on 9-Sep-2018

    Summary

    Official Symbol
    Xrcc3provided by MGI
    Official Full Name
    X-ray repair complementing defective repair in Chinese hamster cells 3provided by MGI
    Primary source
    MGI:MGI:1921585
    See related
    Ensembl:ENSMUSG00000021287 Vega:OTTMUSG00000027508
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. Allelic variants in the human gene are associated with susceptibility to breast cancer and cutaneous malignant melanoma. [provided by RefSeq, Sep 2015]
    Expression
    Ubiquitous expression in ovary adult (RPKM 17.4), colon adult (RPKM 14.1) and 28 other tissues See more
    Orthologs

    Genomic context

    See Xrcc3 in Genome Data Viewer
    Location:
    12; 12 F1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (111803192..111813879, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (113041404..113052052, complement)

    Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 36635 Neighboring gene apoptogenic, mitochondrial 1 Neighboring gene BCL2-associated athanogene 5 Neighboring gene kinesin light chain 1 Neighboring gene zinc finger, FYVE domain containing 21 Neighboring gene protein phosphatase 1, regulatory subunit 13B Neighboring gene NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 4 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • 4432412E01Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-dependent ATPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to crossover junction endodeoxyribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to crossover junction endodeoxyribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to four-way junction DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to four-way junction DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    DNA recombination IEA
    Inferred from Electronic Annotation
    more info
     
    DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
     
    double-strand break repair via synthesis-dependent strand annealing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    interstrand cross-link repair ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mitotic cell cycle spindle assembly checkpoint ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of centrosome duplication ISO
    Inferred from Sequence Orthology
    more info
     
    resolution of mitotic recombination intermediates IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    resolution of mitotic recombination intermediates ISO
    Inferred from Sequence Orthology
    more info
     
    t-circle formation ISO
    Inferred from Sequence Orthology
    more info
     
    telomere maintenance via recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    telomere maintenance via recombination ISO
    Inferred from Sequence Orthology
    more info
     
    telomere maintenance via telomere trimming ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Rad51C-XRCC3 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Rad51C-XRCC3 complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    replication fork IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    replication fork ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    DNA repair protein XRCC3
    Names
    X-ray repair cross-complementing protein 3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028875.3NP_083151.1  DNA repair protein XRCC3

      See identical proteins and their annotated locations for NP_083151.1

      Status: REVIEWED

      Source sequence(s)
      AC152065, AK014491, BC043073, BY275474
      Consensus CDS
      CCDS26187.1
      UniProtKB/Swiss-Prot
      Q9CXE6
      UniProtKB/TrEMBL
      Q80W51
      Related
      ENSMUSP00000021715.5, OTTMUSP00000034360, ENSMUST00000021715.5, OTTMUST00000068090
      Conserved Domains (2) summary
      PRK04301
      Location:2341
      radA; DNA repair and recombination protein RadA; Validated
      cd01123
      Location:82341
      Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

      Range
      111803192..111813879 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516300.1XP_006516363.1  DNA repair protein XRCC3 isoform X1

      Conserved Domains (2) summary
      COG0468
      Location:48188
      RecA; RecA/RadA recombinase [Replication, recombination and repair]
      cl21455
      Location:64270
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
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