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    MKRN1 makorin ring finger protein 1 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 716752, updated on 14-Dec-2025
    Official Symbol
    MKRN1provided by VGNC
    Official Full Name
    makorin ring finger protein 1provided by VGNC
    Primary source
    VGNC:VGNC:81476
    See related
    Ensembl:ENSMMUG00000010420 Ensembl:ENSMMUG00000060002
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
    Try the new Gene page
    Try the new Transcripts and proteins table
    See MKRN1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2025_08 current T2T-MMU8v2.0 (GCF_049350105.2) 3 NC_133408.1 (180293448..180314378, complement)
    103 previous assembly Mmul_10 (GCF_003339765.1) 3 NC_041756.1 (166872513..166893235, complement)

    Chromosome 3 - NC_133408.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 37 member 3 Neighboring gene small nucleolar RNA U13 Neighboring gene RAB19, member RAS oncogene family Neighboring gene uncharacterized LOC144339991 Neighboring gene DENN domain containing 2A

    Go to nucleotide: Graphics FASTA GenBank

    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein polyubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Preferred Names
    E3 ubiquitin-protein ligase makorin-1; makorin ring finger protein 1

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: GCF_049350105.2-RS_2025_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference T2T-MMU8v2.0

    Genomic

    1. NC_133408.1 Reference T2T-MMU8v2.0

      Range
      180293448..180314378 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028846378.2 → XP_028702211.1  E3 ubiquitin-protein ligase makorin-1 isoform X2

      UniProtKB/TrEMBL
      F7CXP2, H9ET53
      Related
      ENSMMUP00000013664.4
      Conserved Domains (3) summary
      PHA03096
      Location:178 → 327
      PHA03096; p28-like protein; Provisional
      cd16730
      Location:235 → 295
      RING-HC_MKRN1_3; RING finger, HC subclass, found in makorin-1 (MKRN1), makorin-3 (MKRN3), and similar proteins
      pfam15815
      Location:349 → 439
      MKRN1_C; E3 ubiquitin-protein ligase makorin-1, C-terminal

    2. XM_015135050.3 → XP_014990536.2  E3 ubiquitin-protein ligase makorin-1 isoform X1

      UniProtKB/TrEMBL
      H9ET53, H9Z143
      Related
      ENSMMUP00000073677.1
      Conserved Domains (5) summary
      PHA03096
      Location:221 → 370
      PHA03096; p28-like protein; Provisional
      cd16730
      Location:278 → 338
      RING-HC_MKRN1_3; RING finger, HC subclass, found in makorin-1 (MKRN1), makorin-3 (MKRN3), and similar proteins
      pfam15815
      Location:392 → 482
      MKRN1_C; E3 ubiquitin-protein ligase makorin-1, C-terminal
      pfam18044
      Location:59 → 80
      zf-CCCH_4; CCCH-type zinc finger
      pfam18345
      Location:90 → 108
      zf_CCCH_4; Zinc finger domain

    3. XM_077997556.1 → XP_077853682.1  E3 ubiquitin-protein ligase makorin-1 isoform X3

    4. XM_077997563.1 → XP_077853689.1  E3 ubiquitin-protein ligase makorin-1 isoform X3

    5. XM_077997567.1 → XP_077853693.1  E3 ubiquitin-protein ligase makorin-1 isoform X3

    6. XM_001107668.5 → XP_001107668.2  E3 ubiquitin-protein ligase makorin-1 isoform X3

      See identical proteins and their annotated locations for XP_001107668.2

      UniProtKB/TrEMBL
      G7MMP2
      Conserved Domains (4) summary
      PHA03096
      Location:157 → 306
      PHA03096; p28-like protein; Provisional
      cd16730
      Location:214 → 274
      RING-HC_MKRN1_3; RING finger, HC subclass, found in makorin-1 (MKRN1), makorin-3 (MKRN3), and similar proteins
      pfam15815
      Location:328 → 418
      MKRN1_C; E3 ubiquitin-protein ligase makorin-1, C-terminal
      pfam18345
      Location:26 → 44
      zf_CCCH_4; Zinc finger domain

    7. XM_077997562.1 → XP_077853688.1  E3 ubiquitin-protein ligase makorin-1 isoform X3

    8. XM_015135051.3 → XP_014990537.1  E3 ubiquitin-protein ligase makorin-1 isoform X3

      UniProtKB/TrEMBL
      G7MMP2
      Conserved Domains (4) summary
      PHA03096
      Location:157 → 306
      PHA03096; p28-like protein; Provisional
      cd16730
      Location:214 → 274
      RING-HC_MKRN1_3; RING finger, HC subclass, found in makorin-1 (MKRN1), makorin-3 (MKRN3), and similar proteins
      pfam15815
      Location:328 → 418
      MKRN1_C; E3 ubiquitin-protein ligase makorin-1, C-terminal
      pfam18345
      Location:26 → 44
      zf_CCCH_4; Zinc finger domain

    9. XM_077997561.1 → XP_077853687.1  E3 ubiquitin-protein ligase makorin-1 isoform X3

    10. XM_077997565.1 → XP_077853691.1  E3 ubiquitin-protein ligase makorin-1 isoform X3

    11. XM_077997558.1 → XP_077853684.1  E3 ubiquitin-protein ligase makorin-1 isoform X3

    12. XM_077997566.1 → XP_077853692.1  E3 ubiquitin-protein ligase makorin-1 isoform X3

    13. XM_077997560.1 → XP_077853686.1  E3 ubiquitin-protein ligase makorin-1 isoform X3

    14. XM_077997559.1 → XP_077853685.1  E3 ubiquitin-protein ligase makorin-1 isoform X3

    15. XM_077997564.1 → XP_077853690.1  E3 ubiquitin-protein ligase makorin-1 isoform X3

    Nucleotide Protein
    Heading Accession and Version

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