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    Yars2 tyrosyl-tRNA synthetase 2 (mitochondrial) [ Mus musculus (house mouse) ]

    Gene ID: 70120, updated on 31-Jan-2019

    Summary

    Official Symbol
    Yars2provided by MGI
    Official Full Name
    tyrosyl-tRNA synthetase 2 (mitochondrial)provided by MGI
    Primary source
    MGI:MGI:1917370
    See related
    Ensembl:ENSMUSG00000022792
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    tyrRS; 2210023C10Rik
    Expression
    Ubiquitous expression in adrenal adult (RPKM 30.6), ovary adult (RPKM 17.1) and 28 other tissues See more
    Orthologs

    Genomic context

    See Yars2 in Genome Data Viewer
    Location:
    16; 16 A2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 16 NC_000082.6 (16302965..16309640)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (16303075..16309721)

    Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene plakophilin 2 Neighboring gene ribosomal protein L30 pseudogene Neighboring gene dynamin 1-like Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    tRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    tyrosine binding ISO
    Inferred from Sequence Orthology
    more info
     
    tyrosine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    tyrosine-tRNA ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    mitochondrial tyrosyl-tRNA aminoacylation ISO
    Inferred from Sequence Orthology
    more info
     
    tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    tRNA aminoacylation ISO
    Inferred from Sequence Orthology
    more info
     
    tRNA aminoacylation for protein translation IEA
    Inferred from Electronic Annotation
    more info
     
    translation IEA
    Inferred from Electronic Annotation
    more info
     
    tyrosyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrion HDA PubMed 
    mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear body ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    tyrosine--tRNA ligase, mitochondrial
    NP_937889.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198246.2NP_937889.1  tyrosine--tRNA ligase, mitochondrial

      See identical proteins and their annotated locations for NP_937889.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes a functional protein.
      Source sequence(s)
      AC112943, AK083653, BC060295
      Consensus CDS
      CCDS27983.1
      UniProtKB/Swiss-Prot
      Q8BYL4
      UniProtKB/TrEMBL
      Q8BJJ2
      Related
      ENSMUSP00000055277.8, ENSMUST00000059955.14
      Conserved Domains (2) summary
      cd00805
      Location:69351
      TyrRS_core; catalytic core domain of tyrosinyl-tRNA synthetase
      PRK05912
      Location:37469
      PRK05912; tyrosyl-tRNA synthetase; Validated

    RNA

    1. NR_038046.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC112943, AK138504
      Related
      ENSMUST00000159683.1

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000082.6 Reference GRCm38.p4 C57BL/6J

      Range
      16302965..16309640
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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