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    Nsmce1 NSE1 homolog, SMC5-SMC6 complex component [ Mus musculus (house mouse) ]

    Gene ID: 67711, updated on 5-Aug-2018

    Summary

    Official Symbol
    Nsmce1provided by MGI
    Official Full Name
    NSE1 homolog, SMC5-SMC6 complex componentprovided by MGI
    Primary source
    MGI:MGI:1914961
    See related
    Ensembl:ENSMUSG00000030750 Vega:OTTMUSG00000029028
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2510027N19Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 62.5), placenta adult (RPKM 30.9) and 28 other tissues See more
    Orthologs

    Genomic context

    See Nsmce1 in Genome Data Viewer
    Location:
    7; 7 F3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (125467640..125491575, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (132611154..132635056, complement)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 30717 Neighboring gene lysine (K)-specific demethylase 8 Neighboring gene guanosine diphosphate (GDP) dissociation inhibitor 2 pseudogene Neighboring gene interleukin 4 receptor, alpha

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein dimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    DNA recombination IEA
    Inferred from Electronic Annotation
    more info
     
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    postreplication repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    Smc5-Smc6 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Smc5-Smc6 complex ISO
    Inferred from Sequence Orthology
    more info
     
    chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    non-structural maintenance of chromosomes element 1 homolog
    Names
    non-SMC element 1 homolog
    NP_080606.2
    XP_006508197.1
    XP_006508198.1
    XP_006508199.1
    XP_017167758.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360659.1NP_001347588.1  non-structural maintenance of chromosomes element 1 homolog isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC125187
      Conserved Domains (2) summary
      pfam07574
      Location:30176
      SMC_Nse1; Nse1 non-SMC component of SMC5-6 complex
      cd16493
      Location:191235
      RING-CH-C4HC3_NSE1; RING-CH finger, H2 subclass (C4HC3-type), found in non-structural maintenance of chromosomes element 1 homolog (NSE1) and similar proteins
    2. NM_026330.3NP_080606.2  non-structural maintenance of chromosomes element 1 homolog isoform 1

      See identical proteins and their annotated locations for NP_080606.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC125187, BC049558, BE991892
      Consensus CDS
      CCDS21822.1
      UniProtKB/Swiss-Prot
      Q9D720
      UniProtKB/TrEMBL
      A0A0R4J0C0
      Related
      ENSMUSP00000033006.7, OTTMUSP00000036985, ENSMUST00000033006.13, OTTMUST00000072018
      Conserved Domains (2) summary
      pfam07574
      Location:30189
      SMC_Nse1; Nse1 non-SMC component of SMC5-6 complex
      cd16493
      Location:204248
      RING-CH-C4HC3_NSE1; RING-CH finger, H2 subclass (C4HC3-type), found in non-structural maintenance of chromosomes element 1 homolog (NSE1) and similar proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      125467640..125491575 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508134.3XP_006508197.1  non-structural maintenance of chromosomes element 1 homolog isoform X1

      Conserved Domains (2) summary
      pfam07574
      Location:30176
      SMC_Nse1; Nse1 non-SMC component of SMC5-6 complex
      cd16493
      Location:191235
      RING-CH-C4HC3_NSE1; RING-CH finger, H2 subclass (C4HC3-type), found in non-structural maintenance of chromosomes element 1 homolog (NSE1) and similar proteins
    2. XM_017312269.1XP_017167758.1  non-structural maintenance of chromosomes element 1 homolog isoform X2

      UniProtKB/Swiss-Prot
      Q9D720
      Conserved Domains (2) summary
      pfam07574
      Location:16175
      SMC_Nse1; Nse1 non-SMC component of SMC5-6 complex
      pfam08746
      Location:191231
      zf-RING-like; RING-like domain
    3. XM_006508136.2XP_006508199.1  non-structural maintenance of chromosomes element 1 homolog isoform X2

      See identical proteins and their annotated locations for XP_006508199.1

      UniProtKB/Swiss-Prot
      Q9D720
      Conserved Domains (2) summary
      pfam07574
      Location:16175
      SMC_Nse1; Nse1 non-SMC component of SMC5-6 complex
      pfam08746
      Location:191231
      zf-RING-like; RING-like domain
    4. XM_006508135.3XP_006508198.1  non-structural maintenance of chromosomes element 1 homolog isoform X2

      See identical proteins and their annotated locations for XP_006508198.1

      UniProtKB/Swiss-Prot
      Q9D720
      Conserved Domains (2) summary
      pfam07574
      Location:16175
      SMC_Nse1; Nse1 non-SMC component of SMC5-6 complex
      pfam08746
      Location:191231
      zf-RING-like; RING-like domain
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