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    UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 [ Homo sapiens (human) ]

    Gene ID: 6675, updated on 11-Jul-2021

    Summary

    Official Symbol
    UAP1provided by HGNC
    Official Full Name
    UDP-N-acetylglucosamine pyrophosphorylase 1provided by HGNC
    Primary source
    HGNC:HGNC:12457
    See related
    Ensembl:ENSG00000117143 MIM:602862
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AGX; AGX1; AGX2; SPAG2
    Expression
    Broad expression in testis (RPKM 52.4), liver (RPKM 41.2) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See UAP1 in Genome Data Viewer
    Location:
    1q23.3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (162561531..162599837)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (162531512..162569627)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ubiquinol-cytochrome c reductase binding protein pseudogene 2 Neighboring gene UAP1 divergent transcript Neighboring gene discoidin domain receptor tyrosine kinase 2 Neighboring gene RNA, 7SL, cytoplasmic 861, pseudogene Neighboring gene hydroxysteroid 17-beta dehydrogenase 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of UDP-N-acteylglucosamine pyrophosphorylase 1 (UAP1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables UDP-N-acetylgalactosamine diphosphorylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables UDP-N-acetylglucosamine diphosphorylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in UDP-N-acetylglucosamine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in UDP-N-acetylglucosamine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    UDP-N-acetylhexosamine pyrophosphorylase
    Names
    UDP-N-acetylglucosamine diphosphorylase 1
    UDP-N-acetylhexosamine pyrophosphorylase 1
    antigen X
    sperm associated antigen 2
    testis tissue sperm-binding protein Li 37a
    NP_001311042.1
    NP_001311043.1
    NP_001311044.1
    NP_001311045.1
    NP_001311046.1
    NP_001375330.1
    NP_001375331.1
    NP_003106.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001324113.2NP_001311042.1  UDP-N-acetylhexosamine pyrophosphorylase isoform a

      Status: VALIDATED

      Source sequence(s)
      AL596325
      Consensus CDS
      CCDS1240.1
      UniProtKB/Swiss-Prot
      Q16222
      UniProtKB/TrEMBL
      A0A140VKC0
      Conserved Domains (1) summary
      cd04193
      Location:88410
      UDPGlcNAc_PPase; UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc
    2. NM_001324114.2NP_001311043.1  UDP-N-acetylhexosamine pyrophosphorylase isoform a

      Status: VALIDATED

      Source sequence(s)
      AL596325
      Consensus CDS
      CCDS1240.1
      UniProtKB/Swiss-Prot
      Q16222
      UniProtKB/TrEMBL
      A0A140VKC0
      Conserved Domains (1) summary
      cd04193
      Location:88410
      UDPGlcNAc_PPase; UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc
    3. NM_001324115.3NP_001311044.1  UDP-N-acetylhexosamine pyrophosphorylase isoform a

      Status: VALIDATED

      Source sequence(s)
      AL596325
      Consensus CDS
      CCDS1240.1
      UniProtKB/Swiss-Prot
      Q16222
      UniProtKB/TrEMBL
      A0A140VKC0
      Conserved Domains (1) summary
      cd04193
      Location:88410
      UDPGlcNAc_PPase; UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc
    4. NM_001324116.5NP_001311045.1  UDP-N-acetylhexosamine pyrophosphorylase isoform b

      Status: VALIDATED

      Source sequence(s)
      AL596325
      Consensus CDS
      CCDS81393.1
      UniProtKB/Swiss-Prot
      Q16222
      Related
      ENSP00000271469.3, ENST00000271469.7
      Conserved Domains (1) summary
      cd04193
      Location:88410
      UDPGlcNAc_PPase; UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc
    5. NM_001324117.3NP_001311046.1  UDP-N-acetylhexosamine pyrophosphorylase isoform c

      Status: VALIDATED

      Source sequence(s)
      AL596325
      Consensus CDS
      CCDS81394.1
      UniProtKB/Swiss-Prot
      Q16222
      Related
      ENSP00000356901.1, ENST00000367924.1
      Conserved Domains (1) summary
      cd04193
      Location:88410
      UDPGlcNAc_PPase; UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc
    6. NM_001388401.1NP_001375330.1  UDP-N-acetylhexosamine pyrophosphorylase isoform b

      Status: VALIDATED

      Source sequence(s)
      AL596325
      Conserved Domains (1) summary
      cd04193
      Location:88410
      UDPGlcNAc_PPase; UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc
    7. NM_001388402.1NP_001375331.1  UDP-N-acetylhexosamine pyrophosphorylase isoform b

      Status: VALIDATED

      Source sequence(s)
      AL596325
      Conserved Domains (1) summary
      cd04193
      Location:88410
      UDPGlcNAc_PPase; UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc
    8. NM_003115.6NP_003106.3  UDP-N-acetylhexosamine pyrophosphorylase isoform a

      See identical proteins and their annotated locations for NP_003106.3

      Status: VALIDATED

      Source sequence(s)
      AL596325
      Consensus CDS
      CCDS1240.1
      UniProtKB/Swiss-Prot
      Q16222
      UniProtKB/TrEMBL
      A0A140VKC0
      Related
      ENSP00000356903.4, ENST00000367926.8
      Conserved Domains (1) summary
      cd04193
      Location:88410
      UDPGlcNAc_PPase; UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      162561531..162599837
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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