Format

Send to:

Choose Destination
    • Showing Current items.

    MAPK12 mitogen-activated protein kinase 12 [ Homo sapiens (human) ]

    Gene ID: 6300, updated on 4-Feb-2021

    Summary

    Official Symbol
    MAPK12provided by HGNC
    Official Full Name
    mitogen-activated protein kinase 12provided by HGNC
    Primary source
    HGNC:HGNC:6874
    See related
    Ensembl:ENSG00000188130 MIM:602399
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ERK3; ERK6; ERK-6; SAPK3; PRKM12; SAPK-3; MAPK 12; P38GAMMA
    Summary
    Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this gene functions as a signal transducer during differentiation of myoblasts to myotubes. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in brain (RPKM 6.0), prostate (RPKM 5.7) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MAPK12 in Genome Data Viewer
    Location:
    22q13.33
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109.20201120 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (50252901..50261683, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (50691330..50700112, complement)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene tubulin gamma complex associated protein 6 Neighboring gene histone deacetylase 10 Neighboring gene mitogen-activated protein kinase 11 Neighboring gene plexin B2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
    GeneReviews: Not available

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 binding to CD4 results in activation of the mitogen-activated protein kinase (MAPK) in CD4(+) lymphocytes prestimulated through their T-cell receptor (TCR) PubMed
    reverse transcriptase gag-pol MEK1 in HIV-1 producer cells is able to activate virion-associated MAPK in trans, and the activated MAPK facilitates efficient disengagement of the HIV-1 reverse transcription complex from the cell membrane and subsequent nuclear translocation PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: HDAC10

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    MAP kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA damage induced protein phosphorylation TAS
    Traceable Author Statement
    more info
    PubMed 
    MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    cell cycle arrest TAS
    Traceable Author Statement
    more info
    PubMed 
    intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    muscle organ development TAS
    Traceable Author Statement
    more info
    PubMed 
    myoblast differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidyl-serine phosphorylation TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of muscle cell differentiation TAS
    Traceable Author Statement
    more info
     
    positive regulation of peptidase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    mitogen-activated protein kinase 12
    Names
    MAP kinase 12
    MAP kinase p38 gamma
    extracellular signal-regulated kinase 6
    mitogen-activated protein kinase 3
    mitogen-activated protein kinase p38 gamma
    stress-activated protein kinase 3
    NP_001290181.1
    NP_002960.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001303252.3NP_001290181.1  mitogen-activated protein kinase 12 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region compared to variant 1. This difference results in a shorter isoform (2), compared to isoform 1.
      Source sequence(s)
      BC015741, BX640648, CB123561, N94360, U66243, Y10487
      Consensus CDS
      CCDS77688.1
      UniProtKB/Swiss-Prot
      P53778
      UniProtKB/TrEMBL
      Q6N076
      Related
      ENSP00000479972.1, ENST00000622558.4
      Conserved Domains (2) summary
      cd07880
      Location:11343
      STKc_p38gamma; Catalytic domain of the Serine/Threonine Kinase, p38gamma Mitogen-Activated Protein Kinase (also called MAPK12)
      smart00220
      Location:27301
      S_TKc; Serine/Threonine protein kinases, catalytic domain
    2. NM_002969.6NP_002960.2  mitogen-activated protein kinase 12 isoform 1

      See identical proteins and their annotated locations for NP_002960.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC015741, CB123561, N94360, U66243, Y10487
      Consensus CDS
      CCDS14089.1
      UniProtKB/Swiss-Prot
      P53778
      Related
      ENSP00000215659.8, ENST00000215659.13
      Conserved Domains (1) summary
      cd07880
      Location:11353
      STKc_p38gamma; Catalytic domain of the Serine/Threonine Kinase, p38gamma Mitogen-Activated Protein Kinase (also called MAPK12)

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

      Range
      50252901..50261683 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center