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    QARS1 glutaminyl-tRNA synthetase 1 [ Homo sapiens (human) ]

    Gene ID: 5859, updated on 5-Sep-2021

    Summary

    Official Symbol
    QARS1provided by HGNC
    Official Full Name
    glutaminyl-tRNA synthetase 1provided by HGNC
    Primary source
    HGNC:HGNC:9751
    See related
    Ensembl:ENSG00000172053 MIM:603727
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    QARS; GLNRS; MSCCA; PRO2195
    Summary
    Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. In metazoans, 9 aminoacyl-tRNA synthetases specific for glutamine (gln), glutamic acid (glu), and 7 other amino acids are associated within a multienzyme complex. Although present in eukaryotes, glutaminyl-tRNA synthetase (QARS) is absent from many prokaryotes, mitochondria, and chloroplasts, in which Gln-tRNA(Gln) is formed by transamidation of the misacylated Glu-tRNA(Gln). Glutaminyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
    Expression
    Ubiquitous expression in colon (RPKM 48.6), skin (RPKM 46.9) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See QARS1 in Genome Data Viewer
    Location:
    3p21.31
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (49095932..49104758, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (49133365..49142190, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene inosine monophosphate dehydrogenase 2 Neighboring gene glutamine rich 1 Neighboring gene RNA, 7SL, cytoplasmic 182, pseudogene Neighboring gene microRNA 6890 Neighboring gene ubiquitin specific peptidase 19 Neighboring gene laminin subunit beta 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Interaction of HIV-1 Gag with glutaminyl-tRNA synthetase (QARS) is identified in a series of six affinity purification/mass spectrometry screens PubMed
    matrix gag HIV-1 MA is identified to have a physical interaction with glutaminyl-tRNA synthetase (QARS) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables glutamine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables glutamine-tRNA ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables glutamine-tRNA ligase activity TAS
    Traceable Author Statement
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase inhibitor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of aminoacyl-tRNA synthetase multienzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of aminoacyl-tRNA synthetase multienzyme complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in mitochondrial matrix TAS
    Traceable Author Statement
    more info
     
    part_of protein-containing complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    glutamine--tRNA ligase
    Names
    glutamine-tRNA synthetase
    NP_001259002.1
    NP_005042.1
    XP_016862454.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_042312.1 RefSeqGene

      Range
      5373..14198
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272073.2NP_001259002.1  glutamine--tRNA ligase isoform b

      See identical proteins and their annotated locations for NP_001259002.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (b) is shorter compared to isoform a.
      Source sequence(s)
      AK301559, BC000394
      Consensus CDS
      CCDS63633.1
      UniProtKB/Swiss-Prot
      P47897
      UniProtKB/TrEMBL
      B7Z840
      Related
      ENSP00000390015.1, ENST00000414533.5
      Conserved Domains (5) summary
      PLN02859
      Location:6763
      PLN02859; glutamine-tRNA ligase
      cd00807
      Location:252556
      GlnRS_core; catalytic core domain of glutaminyl-tRNA synthetase
      pfam03950
      Location:554741
      tRNA-synt_1c_C; tRNA synthetases class I (E and Q), anti-codon binding domain
      pfam04557
      Location:154245
      tRNA_synt_1c_R2; Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2
      pfam04558
      Location:10151
      tRNA_synt_1c_R1; Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1
    2. NM_005051.3NP_005042.1  glutamine--tRNA ligase isoform a

      See identical proteins and their annotated locations for NP_005042.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      BC000394, BM560535
      Consensus CDS
      CCDS2788.1
      UniProtKB/Swiss-Prot
      P47897
      UniProtKB/TrEMBL
      B7Z840
      Related
      ENSP00000307567.6, ENST00000306125.12
      Conserved Domains (5) summary
      PLN02859
      Location:6774
      PLN02859; glutamine-tRNA ligase
      cd00807
      Location:263567
      GlnRS_core; catalytic core domain of glutaminyl-tRNA synthetase
      pfam03950
      Location:565752
      tRNA-synt_1c_C; tRNA synthetases class I (E and Q), anti-codon binding domain
      pfam04557
      Location:165256
      tRNA_synt_1c_R2; Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2
      pfam04558
      Location:10162
      tRNA_synt_1c_R1; Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1

    RNA

    1. NR_073590.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK056815, BC000394, BC001567
      Related
      ENST00000430182.5

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

      Range
      49095932..49104758 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017006965.2XP_016862454.2  glutamine--tRNA ligase isoform X1

      Conserved Domains (1) summary
      cl27212
      Location:6732
      GlnS; Glutamyl- or glutaminyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
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