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    notch3 notch 3 [ Danio rerio (zebrafish) ]

    Gene ID: 58066, updated on 28-Oct-2018

    Summary

    Official Symbol
    notch3provided by ZNC
    Official Full Name
    notch 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-000329-5
    See related
    Ensembl:ENSDARG00000052139 Vega:OTTDARG00000035144
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Danio
    Also known as
    notch5; fa14b08; wu:fa14b08

    Genomic context

    See notch3 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (53529714..53559408, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (53275051..53304745, complement)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene zmp:0000001048 Neighboring gene zgc:171711 Neighboring gene retinol dehydrogenase 8a Neighboring gene collagen, type V, alpha 3a

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    General gene information

    Markers

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Notch signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    arterial endothelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    blood vessel morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    dorsal aorta development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    dorsal aorta development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hematopoietic progenitor cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    hematopoietic progenitor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    liver development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    liver development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    maintenance of permeability of blood-brain barrier IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of neurogenesis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    negative regulation of neurogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    neural plate development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    neuronal stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    oligodendrocyte development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    oligodendrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peripheral nervous system neuron axonogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    pronephros development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of blood vessel size IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of developmental process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of receptor-mediated endocytosis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of vascular permeability IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    rhombomere boundary formation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    sclerotome development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    sclerotome development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    somatic stem cell population maintenance IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    symmetric cell division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ventral spinal cord interneuron differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    neurogenic locus notch homolog protein 3
    Names
    notch homolog 3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131549.2NP_571624.2  neurogenic locus notch homolog protein 3 precursor

      See identical proteins and their annotated locations for NP_571624.2

      Status: PROVISIONAL

      Source sequence(s)
      AF152001
      UniProtKB/TrEMBL
      Q800E4
      Related
      ENSDARP00000068420.4, OTTDARP00000039201, ENSDART00000073930.7, OTTDART00000049952
      Conserved Domains (11) summary
      smart00818
      Location:22322325
      Amelogenin; Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth
      COG0666
      Location:17841896
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00054
      Location:824860
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00204
      Location:18691995
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam00066
      Location:14291462
      Notch; LNR domain
      pfam06816
      Location:15081559
      NOD; NOTCH protein
      pfam07684
      Location:15771634
      NODP; NOTCH protein
      pfam11936
      Location:23842445
      DUF3454; Domain of unknown function (DUF3454)
      pfam12796
      Location:19132005
      Ank_2; Ankyrin repeats (3 copies)
      pfam13857
      Location:18611916
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:19081939
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      53529714..53559408 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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