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    MIER1 MIER1 transcriptional regulator [ Homo sapiens (human) ]

    Gene ID: 57708, updated on 2-Oct-2018

    Summary

    Official Symbol
    MIER1provided by HGNC
    Official Full Name
    MIER1 transcriptional regulatorprovided by HGNC
    Primary source
    HGNC:HGNC:29657
    See related
    Ensembl:ENSG00000198160 MIM:616848; Vega:OTTHUMG00000009194
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ER1; MI-ER1
    Summary
    This gene encodes a protein that was first identified in Xenopus laevis by its role in a mesoderm induction early response (MIER). The encoded protein functions as a transcriptional regulator. Alternatively spliced transcript variants encode multiple isoforms, some of which lack a C-terminal nuclear localization signal. [provided by RefSeq, May 2013]
    Expression
    Ubiquitous expression in bone marrow (RPKM 19.6), colon (RPKM 10.3) and 24 other tissues See more
    Orthologs

    Genomic context

    See MIER1 in Genome Data Viewer
    Location:
    1p31.3
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (66924895..66988619)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (67390578..67454302)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene insulin like 5 Neighboring gene WD repeat domain 78 Neighboring gene solute carrier family 35 member D1 Neighboring gene chromosome 1 open reading frame 141 Neighboring gene interleukin 23 receptor

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA1610, MGC131940, MGC150640, MGC150641, DKFZp781G0451

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
     
    DNA-binding transcription factor activity, RNA polymerase II-specific ISM
    Inferred from Sequence Model
    more info
    PubMed 
    DNA-binding transcription factor activity, RNA polymerase II-specific NAS
    Non-traceable Author Statement
    more info
    PubMed 
    RNA polymerase II repressing transcription factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    histone deacetylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone deacetylase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    histone deacetylase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcriptional repressor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    mesoderm induction early response protein 1
    Names
    mesoderm induction early response 1 homolog
    mesoderm induction early response 1, transcriptional regulator

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029847.1 RefSeqGene

      Range
      5001..68725
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001077700.2NP_001071168.2  mesoderm induction early response protein 1 isoform b

      See identical proteins and their annotated locations for NP_001071168.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region and uses an alternate upstream translation start site, compared to variant 1. The resulting isoform (b) has a longer and distinct N-terminus, compared to isoform a.
      Source sequence(s)
      AK302061, AL500525, BM987758
      Consensus CDS
      CCDS53326.1
      UniProtKB/Swiss-Prot
      Q8N108
      Related
      ENSP00000383820.1, OTTHUMP00000010963, ENST00000401041.5, OTTHUMT00000025944
      Conserved Domains (2) summary
      cd11661
      Location:341385
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:235284
      ELM2; ELM2 domain
    2. NM_001077701.2NP_001071169.1  mesoderm induction early response protein 1 isoform c

      See identical proteins and their annotated locations for NP_001071169.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The resulting isoform (c, also known as N3-beta) has a shorter and distinct N-terminus, compared to isoform a.
      Source sequence(s)
      AF515446, AL500525, BM987758
      Consensus CDS
      CCDS41348.1
      UniProtKB/Swiss-Prot
      Q8N108
      Related
      ENSP00000347514.3, OTTHUMP00000010783, ENST00000355356.3, OTTHUMT00000025491
      Conserved Domains (2) summary
      cd11661
      Location:288332
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:182231
      ELM2; ELM2 domain
    3. NM_001077702.2NP_001071170.2  mesoderm induction early response protein 1 isoform d precursor

      See identical proteins and their annotated locations for NP_001071170.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an alternate segment in the 3' coding region, compared to variant 1. The resulting isoform (d) has a shorter and distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AF515448, AK302061, AL500525, BM987758
      Consensus CDS
      CCDS53327.1
      UniProtKB/Swiss-Prot
      Q8N108
      Related
      ENSP00000360055.1, OTTHUMP00000010960, ENST00000371016.5, OTTHUMT00000025941
      Conserved Domains (2) summary
      cd11661
      Location:305349
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:199248
      ELM2; ELM2 domain
    4. NM_001077703.2NP_001071171.2  mesoderm induction early response protein 1 isoform e

      See identical proteins and their annotated locations for NP_001071171.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an alternate exon in the 5' coding region, uses an alternate upstream translation start site, and lacks an alternate segment in the 3' coding region, compared to variant 1. The resulting isoform (e) has a longer and distinct N-terminus and a shorter and distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AK302061, AL500525, AY124187, BM987758
      Consensus CDS
      CCDS53325.1
      UniProtKB/Swiss-Prot
      Q8N108
      Related
      ENSP00000360053.1, OTTHUMP00000010962, ENST00000371014.5, OTTHUMT00000025943
      Conserved Domains (2) summary
      cd11661
      Location:341385
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:235284
      ELM2; ELM2 domain
    5. NM_001077704.2NP_001071172.1  mesoderm induction early response protein 1 isoform f

      See identical proteins and their annotated locations for NP_001071172.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region, initiates translation at an alternate start codon, and lacks an alternate segment in the 3' coding region, compared to variant 1. The resulting isoform (f, also known as N3-alpha), has shorter and distinct N- and C-termini, compared to isoform a.
      Source sequence(s)
      AL500525, AY124188, BM987758
      Consensus CDS
      CCDS41347.1
      UniProtKB/Swiss-Prot
      Q8N108
      Related
      ENSP00000383821.3, OTTHUMP00000010961, ENST00000401042.7, OTTHUMT00000025942
      Conserved Domains (2) summary
      cd11661
      Location:288332
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:182231
      ELM2; ELM2 domain
    6. NM_001146110.1NP_001139582.1  mesoderm induction early response protein 1 isoform a precursor

      See identical proteins and their annotated locations for NP_001139582.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) uses an alternate splice site in the 5' UTR compared to variant 1. Both variants 1 and 10 encode the same isoform (a).
      Source sequence(s)
      AK302061, AK307717, AL500525, BC108726, BM987758
      Consensus CDS
      CCDS53329.1
      UniProtKB/Swiss-Prot
      Q8N108
      Related
      ENSP00000350321.2, OTTHUMP00000010782, ENST00000357692.6, OTTHUMT00000025490
      Conserved Domains (2) summary
      cd11661
      Location:305349
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:199248
      ELM2; ELM2 domain
    7. NM_001146111.1NP_001139583.1  mesoderm induction early response protein 1 isoform g precursor

      See identical proteins and their annotated locations for NP_001139583.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks an alternate segment in the 3' coding region, compared to variant 1. The resulting isoform (g) has a shorter and distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AK302061, AL500525, BC108726, BM987758
      Consensus CDS
      CCDS53328.1
      UniProtKB/Swiss-Prot
      Q8N108
      Related
      ENSP00000360057.3, ENST00000371018.7
      Conserved Domains (2) summary
      cd11661
      Location:305349
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:199248
      ELM2; ELM2 domain
    8. NM_001146112.1NP_001139584.1  mesoderm induction early response protein 1 isoform h

      See identical proteins and their annotated locations for NP_001139584.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) lacks a portion of the 5' coding region and initiates translation at a downstream in-frame start codon, compared to variant 1. The resulting isoform (h) has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AF515446, AK302061, AL139216, AL500525, BM987758
      UniProtKB/Swiss-Prot
      Q8N108
      Conserved Domains (3) summary
      smart00717
      Location:261306
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd11661
      Location:261305
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:155204
      ELM2; ELM2 domain
    9. NM_001146113.1NP_001139585.1  mesoderm induction early response protein 1 isoform i

      See identical proteins and their annotated locations for NP_001139585.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) lacks two alternate exons in the 5' coding region, initiates translation at a downsteram in-frame start codon, and lacks an alternate segment in the 3' coding region, compared to variant 1. The resulting isoform (i) has a shorter N-terminus and a shorter and distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AK302061, AL500525, BC125217, BM987758
      Consensus CDS
      CCDS53330.1
      UniProtKB/Swiss-Prot
      Q8N108
      Related
      ENSP00000348253.6, ENST00000355977.10
      Conserved Domains (2) summary
      cd11661
      Location:225269
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:119168
      ELM2; ELM2 domain
    10. NM_001278215.1NP_001265144.1  mesoderm induction early response protein 1 isoform j precursor

      See identical proteins and their annotated locations for NP_001265144.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) lacks multiple 3' exons and its transcription extends past a splice site used in variant 1, resulting in a distinct 3' coding region and 3' UTR. The encoded isoform (j) has a shorter and distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AK302061, AL139216, BC066898
      Consensus CDS
      CCDS60163.1
      UniProtKB/Swiss-Prot
      Q8N108
      Related
      ENSP00000360051.2, OTTHUMP00000010959, ENST00000371012.6, OTTHUMT00000025938
    11. NM_001350530.1NP_001337459.1  mesoderm induction early response protein 1 isoform k

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12) contains an alternate exon in its 5' coding region, resulting in a shorter 5' UTR and the use of an alternate upstream translation start site, compared to variant 1. The resulting isoform (k) has a longer and distinct N-terminus, compared to isoform a
      Source sequence(s)
      AF515448, AK302061, AL139216, AL500525, BM987758, CB998535
      Conserved Domains (2) summary
      cd11661
      Location:378422
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:272321
      ELM2; ELM2 domain
    12. NM_020948.3NP_065999.2  mesoderm induction early response protein 1 isoform a precursor

      See identical proteins and their annotated locations for NP_065999.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform a. Both variants 1 and 10 encode the same isoform (a).
      Source sequence(s)
      AF515448, AK302061, AL500525, BM987758
      Consensus CDS
      CCDS53329.1
      UniProtKB/Swiss-Prot
      Q8N108
      Conserved Domains (2) summary
      cd11661
      Location:305349
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:199248
      ELM2; ELM2 domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

      Range
      66924895..66988619
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017001932.1XP_016857421.1  mesoderm induction early response protein 1 isoform X9

    2. XM_017001921.1XP_016857410.1  mesoderm induction early response protein 1 isoform X3

      Conserved Domains (3) summary
      smart00717
      Location:321366
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd11661
      Location:321365
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:215264
      ELM2; ELM2 domain
    3. XM_017001923.1XP_016857412.1  mesoderm induction early response protein 1 isoform X4

    4. XM_011541865.2XP_011540167.1  mesoderm induction early response protein 1 isoform X1

      Conserved Domains (3) summary
      smart00717
      Location:365410
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd11661
      Location:365409
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:259308
      ELM2; ELM2 domain
    5. XM_017001929.1XP_016857418.1  mesoderm induction early response protein 1 isoform X7

      Conserved Domains (3) summary
      smart00717
      Location:287332
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd11661
      Location:287331
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:181230
      ELM2; ELM2 domain
    6. XM_017001926.1XP_016857415.1  mesoderm induction early response protein 1 isoform X5

      UniProtKB/Swiss-Prot
      Q8N108
      Conserved Domains (2) summary
      cd11661
      Location:305349
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:199248
      ELM2; ELM2 domain
    7. XM_017001924.1XP_016857413.1  mesoderm induction early response protein 1 isoform X5

      UniProtKB/Swiss-Prot
      Q8N108
      Conserved Domains (2) summary
      cd11661
      Location:305349
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:199248
      ELM2; ELM2 domain
    8. XM_005271076.3XP_005271133.1  mesoderm induction early response protein 1 isoform X5

      See identical proteins and their annotated locations for XP_005271133.1

      UniProtKB/Swiss-Prot
      Q8N108
      Conserved Domains (2) summary
      cd11661
      Location:305349
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:199248
      ELM2; ELM2 domain
    9. XM_017001919.1XP_016857408.1  mesoderm induction early response protein 1 isoform X2

      Conserved Domains (3) summary
      smart00717
      Location:324369
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd11661
      Location:324368
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:218267
      ELM2; ELM2 domain
    10. XM_017001931.1XP_016857420.1  mesoderm induction early response protein 1 isoform X8

      UniProtKB/Swiss-Prot
      Q8N108
      Conserved Domains (3) summary
      smart00717
      Location:261306
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd11661
      Location:261305
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:155204
      ELM2; ELM2 domain
    11. XM_017001927.1XP_016857416.1  mesoderm induction early response protein 1 isoform X6

      UniProtKB/Swiss-Prot
      Q8N108
      Conserved Domains (3) summary
      smart00717
      Location:287332
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd11661
      Location:287331
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:181230
      ELM2; ELM2 domain
    12. XM_017001928.2XP_016857417.1  mesoderm induction early response protein 1 isoform X6

      UniProtKB/Swiss-Prot
      Q8N108
      Conserved Domains (3) summary
      smart00717
      Location:287332
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd11661
      Location:287331
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:181230
      ELM2; ELM2 domain
    13. XM_017001925.1XP_016857414.1  mesoderm induction early response protein 1 isoform X5

      UniProtKB/Swiss-Prot
      Q8N108
      Conserved Domains (2) summary
      cd11661
      Location:305349
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:199248
      ELM2; ELM2 domain
    14. XM_017001922.1XP_016857411.1  mesoderm induction early response protein 1 isoform X3

      Conserved Domains (3) summary
      smart00717
      Location:321366
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd11661
      Location:321365
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:215264
      ELM2; ELM2 domain
    15. XM_017001920.1XP_016857409.1  mesoderm induction early response protein 1 isoform X2

      Conserved Domains (3) summary
      smart00717
      Location:324369
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd11661
      Location:324368
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:218267
      ELM2; ELM2 domain
    16. XM_017001930.1XP_016857419.1  mesoderm induction early response protein 1 isoform X7

      Conserved Domains (3) summary
      smart00717
      Location:287332
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd11661
      Location:287331
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:181230
      ELM2; ELM2 domain
    17. XM_017001933.1XP_016857422.1  mesoderm induction early response protein 1 isoform X9

    18. XM_017001934.1XP_016857423.1  mesoderm induction early response protein 1 isoform X9

    RNA

    1. XR_001737345.1 RNA Sequence

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