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    TAS2R38 taste 2 receptor member 38 [ Homo sapiens (human) ]

    Gene ID: 5726, updated on 5-Jan-2022

    Summary

    Official Symbol
    TAS2R38provided by HGNC
    Official Full Name
    taste 2 receptor member 38provided by HGNC
    Primary source
    HGNC:HGNC:9584
    See related
    Ensembl:ENSG00000257138 MIM:607751
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PTC; T2R38; T2R61; THIOT
    Summary
    This gene encodes a seven-transmembrane G protein-coupled receptor that controls the ability to taste glucosinolates, a family of bitter-tasting compounds found in plants of the Brassica sp. Synthetic compounds phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) have been identified as ligands for this receptor and have been used to test the genetic diversity of this gene. Although several allelic forms of this gene have been identified worldwide, there are two predominant common forms (taster and non-taster) found outside of Africa. These alleles differ at three nucleotide positions resulting in amino acid changes in the protein (A49P, A262V, and V296I) with the amino acid combination PAV identifying the taster variant (and AVI identifying the non-taster variant). [provided by RefSeq, Oct 2009]
    Orthologs
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    Genomic context

    See TAS2R38 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (141972631..141973773, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (141672431..141673573, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 9 subfamily A member 4 Neighboring gene C-type lectin domain containing 5A Neighboring gene maltase-glucoamylase Neighboring gene maltase-glucoamylase 2 (putative)

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Genetic variants associated with disordered eating.
    GeneReviews: Not available
    GWAS of human bitter taste perception identifies new loci and reveals additional complexity of bitter taste genetics.
    GeneReviews: Not available
    The perception of quinine taste intensity is associated with common genetic variants in a bitter receptor cluster on chromosome 12.
    GeneReviews: Not available
    Thiourea tasting
    MedGen: C1868397 OMIM: 171200 GeneReviews: Not available
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    General protein information

    Preferred Names
    taste receptor type 2 member 38
    Names
    PTC bitter taste receptor
    taste receptor type 2 member 61
    taste receptor, type 2, member 38

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016141.1 RefSeqGene

      Range
      5001..6143
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_176817.5NP_789787.5  taste receptor type 2 member 38

      Status: REVIEWED

      Source sequence(s)
      AC073647
      Consensus CDS
      CCDS34765.1
      Related
      ENSP00000448219.1, ENST00000547270.1
      Conserved Domains (1) summary
      cd15025
      Location:16309
      7tm_TAS2R38; mammalian taste receptor 2, subtype 38, member of the seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

      Range
      141972631..141973773 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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