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    MAPK13 mitogen-activated protein kinase 13 [ Homo sapiens (human) ]

    Gene ID: 5603, updated on 2-Mar-2021

    Summary

    Official Symbol
    MAPK13provided by HGNC
    Official Full Name
    mitogen-activated protein kinase 13provided by HGNC
    Primary source
    HGNC:HGNC:6875
    See related
    Ensembl:ENSG00000156711 MIM:602899
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SAPK4; PRKM13; MAPK 13; MAPK-13; p38delta
    Summary
    This gene encodes a member of the mitogen-activated protein (MAP) kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The encoded protein is a p38 MAP kinase and is activated by proinflammatory cytokines and cellular stress. Substrates of the encoded protein include the transcription factor ATF2 and the microtubule dynamics regulator stathmin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]
    Expression
    Broad expression in skin (RPKM 21.7), small intestine (RPKM 17.1) and 22 other tissues See more
    Orthologs
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    Genomic context

    See MAPK13 in Genome Data Viewer
    Location:
    6p21.31
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109.20210226 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (36130513..36144521)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (36098290..36112298)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 26 member 8 Neighboring gene uncharacterized LOC105375034 Neighboring gene mitogen-activated protein kinase 14 Neighboring gene ADP-sugar pyrophosphatase pseudogene Neighboring gene uncharacterized LOC102723648 Neighboring gene bromodomain and PHD finger containing 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 binding to CD4 results in activation of the mitogen-activated protein kinase (MAPK) in CD4(+) lymphocytes prestimulated through their T-cell receptor (TCR) PubMed
    Nef nef HIV-1 Nef involves MAPK13 in the regulation of IL6 expression PubMed
    nef Knockdown of p38 MAPK alpha or delta by siRNA shows significant reduction of CCL5 levels, suggesting that p38 MAPK alpha and delta proteins are involved in Nef-mediated upregulation of CCL5 PubMed
    Pr55(Gag) gag The amplified luminescent proximity homogeneous assay (AlphaScreen) identifies the interaction of HIV-1 Gag with p38delta PubMed
    Tat tat HIV-1 Tat-mediated upregulation of CCL5 involves JAK2/3, AKT2/3, p38delta, NF-kappaB (p65/p50), C/EBP alpha/gamma, and AP-1 proteins PubMed
    Vpr vpr p38-MAPK13 (delta isoform of p38-MAPK) is involved in Vpr-mediated IL6 induction in astrocytes PubMed
    vpr HIV-1 Vpr-induced upregulation of CCL5 requires p50 and p65 subunits of NF-kappaB, p38delta MAPK, Akt-2 and Akt-3, and AP-1 transcription factor in HIV-1 Vpr transfected astrocytes PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC99536

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    MAP kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    MAP kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to UV IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to anisomycin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to hydrogen peroxide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to interleukin-1 IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to sodium arsenite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to sorbitol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of inflammatory response IC
    Inferred by Curator
    more info
    PubMed 
    positive regulation of interleukin-6 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to osmotic stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    stress-activated MAPK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    mitogen-activated protein kinase 13
    Names
    MAP kinase 13
    MAP kinase p38 delta
    mitogen-activated protein kinase p38 delta
    stress-activated protein kinase 4
    NP_002745.1
    XP_024302259.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002754.5NP_002745.1  mitogen-activated protein kinase 13

      See identical proteins and their annotated locations for NP_002745.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and is protein-coding.
      Source sequence(s)
      AF092535, DB335275, DB473379, DR006449, U93232, Z95152
      Consensus CDS
      CCDS4818.1
      UniProtKB/Swiss-Prot
      O15264
      UniProtKB/TrEMBL
      A0A024RD04
      Related
      ENSP00000211287.4, ENST00000211287.9
      Conserved Domains (1) summary
      cd07879
      Location:9351
      STKc_p38delta; Catalytic domain of the Serine/Threonine Kinase, p38delta Mitogen-Activated Protein Kinase (also called MAPK13)

    RNA

    1. NR_072996.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks two consecutive internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      BC085196, DB335275, DB473379, DR006449, Z95152
      Related
      ENST00000373766.9

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

      Range
      36130513..36144521
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024446491.1XP_024302259.1  mitogen-activated protein kinase 13 isoform X1

      Conserved Domains (1) summary
      cl21453
      Location:1273
      PKc_like; Protein Kinases, catalytic domain
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