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    ZNF701 zinc finger protein 701 [ Homo sapiens (human) ]

    Gene ID: 55762, updated on 5-Mar-2024

    Summary

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    Official Symbol
    ZNF701provided by HGNC
    Official Full Name
    zinc finger protein 701provided by HGNC
    Primary source
    HGNC:HGNC:25597
    See related
    Ensembl:ENSG00000167562 AllianceGenome:HGNC:25597
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thyroid (RPKM 1.6), placenta (RPKM 1.6) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    Location:
    19q13.41
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (52570287..52600149)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (55654861..55684595)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (53073540..53090427)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 578 Neighboring gene zinc finger protein 347 pseudogene Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:52986584-52987370 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:52987371-52988156 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:52990721-52991690 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:52996369-52997007 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:52997008-52997645 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:53003665-53004504 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:53029540-53030366 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:53030367-53031194 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:53039321-53039907 Neighboring gene zinc finger protein 808 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:53061637-53062248 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:53062249-53062862 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:53072140-53072749 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15051 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:53073969-53074577 Neighboring gene ribosomal protein L39 pseudogene 34 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:53091538-53091757 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10995 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:53104606-53105112 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15054 Neighboring gene zinc finger protein 137, pseudogene Neighboring gene zinc finger protein 677-like Neighboring gene zinc finger protein 83 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:53140536-53141054 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:53141055-53141572 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10996 Neighboring gene Sharpr-MPRA regulatory region 1800 Neighboring gene Zinc finger protein LOC122539214 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:53167404-53167904 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:53171845-53172346 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:53172853-53174052 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:53177263-53177762 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:53179336-53179900 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:53179901-53180465 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:53192883-53193418 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10997

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Mediating effect of genome-wide DNA methylation on suicidal ideation induced by perceived stress. Dada O, et al. Psychiatr Genet, 2021 Oct 1. PMID 34050117
    2. Molecular basis for recognition of Gly/N-degrons by CRL2(ZYG11B) and CRL2(ZER1). Yan X, et al. Mol Cell, 2021 Aug 19. PMID 34214466
    3. Regulation of epidermal differentiation through KDF1-mediated deubiquitination of IKKα. Li Y, et al. EMBO Rep, 2020 May 6. PMID 32239614, Free PMC Article
    4. A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication. Yeung ML, et al. J Biol Chem, 2009 Jul 17. PMID 19460752, Free PMC Article
    5. ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold. Yang W, et al. Theranostics, 2022. PMID 36168627, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mediating effect of genome-wide DNA methylation on suicidal ideation induced by perceived stress.
      Title: Mediating effect of genome-wide DNA methylation on suicidal ideation induced by perceived stress.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of zinc finger protein 701 (ZNF701) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ10891

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 701

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001172655.1 → NP_001166126.1  zinc finger protein 701 isoform 1

      See identical proteins and their annotated locations for NP_001166126.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC022150, BC067346
      Consensus CDS
      CCDS54311.1
      UniProtKB/Swiss-Prot
      A2RRM8, B9EGF2, F5GZM6, Q66K42, Q9NV72
      Related
      ENSP00000444339.1, ENST00000540331.1
      Conserved Domains (5) summary
      smart00349
      Location:74 → 114
      KRAB; krueppel associated box
      COG5048
      Location:390 → 527
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:338 → 358
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:74 → 113
      KRAB; KRAB box
      pfam13465
      Location:406 → 431
      zf-H2C2_2; Zinc-finger double domain

    2. NM_018260.3 → NP_060730.2  zinc finger protein 701 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR, lacks an alternate exon, and uses a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC022150
      Consensus CDS
      CCDS33092.1
      UniProtKB/Swiss-Prot
      Q9NV72
      Related
      ENSP00000375662.2, ENST00000391785.8
      Conserved Domains (5) summary
      smart00349
      Location:8 → 48
      KRAB; krueppel associated box
      COG5048
      Location:324 → 461
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:272 → 292
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:8 → 47
      KRAB; KRAB box
      pfam13465
      Location:340 → 365
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      52570287..52600149
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047439071.1 → XP_047295027.1  zinc finger protein 701 isoform X1

      UniProtKB/Swiss-Prot
      A2RRM8, B9EGF2, F5GZM6, Q66K42, Q9NV72

    2. XM_047439072.1 → XP_047295028.1  zinc finger protein 701 isoform X1

      UniProtKB/Swiss-Prot
      A2RRM8, B9EGF2, F5GZM6, Q66K42, Q9NV72

    3. XM_047439074.1 → XP_047295030.1  zinc finger protein 701 isoform X1

      UniProtKB/Swiss-Prot
      A2RRM8, B9EGF2, F5GZM6, Q66K42, Q9NV72

    4. XM_047439073.1 → XP_047295029.1  zinc finger protein 701 isoform X1

      UniProtKB/Swiss-Prot
      A2RRM8, B9EGF2, F5GZM6, Q66K42, Q9NV72
      Related
      ENSP00000301093.2, ENST00000301093.6

    5. XM_047439075.1 → XP_047295031.1  zinc finger protein 701 isoform X2

    6. XM_047439077.1 → XP_047295033.1  zinc finger protein 701 isoform X2

    7. XM_047439076.1 → XP_047295032.1  zinc finger protein 701 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      55654861..55684595
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321412.1 → XP_054177387.1  zinc finger protein 701 isoform X1

    2. XM_054321413.1 → XP_054177388.1  zinc finger protein 701 isoform X1

    3. XM_054321415.1 → XP_054177390.1  zinc finger protein 701 isoform X1

    4. XM_054321414.1 → XP_054177389.1  zinc finger protein 701 isoform X1

    5. XM_054321416.1 → XP_054177391.1  zinc finger protein 701 isoform X2

    6. XM_054321418.1 → XP_054177393.1  zinc finger protein 701 isoform X2

    7. XM_054321417.1 → XP_054177392.1  zinc finger protein 701 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NV72.3 GenPept UniProtKB/Swiss-Prot:Q9NV72

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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