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    G2E3 G2/M-phase specific E3 ubiquitin protein ligase [ Homo sapiens (human) ]

    Gene ID: 55632, updated on 8-Jul-2021

    Summary

    Official Symbol
    G2E3provided by HGNC
    Official Full Name
    G2/M-phase specific E3 ubiquitin protein ligaseprovided by HGNC
    Primary source
    HGNC:HGNC:20338
    See related
    Ensembl:ENSG00000092140 MIM:611299
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PHF7B; KIAA1333
    Expression
    Broad expression in testis (RPKM 10.5), lymph node (RPKM 4.4) and 24 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See G2E3 in Genome Data Viewer
    Location:
    14q12
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (30559136..30620064)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (31028364..31089270)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene G2E3 antisense RNA 1 Neighboring gene uncharacterized LOC105370432 Neighboring gene SYF2 pre-mRNA splicing factor pseudogene 1 Neighboring gene sec1 family domain containing 1 Neighboring gene ubiquitin conjugating enzyme E2 C pseudogene 1 Neighboring gene ribosomal protein L12 pseudogene 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ20333, KIAA1333

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    G2/M phase-specific E3 ubiquitin-protein ligase
    Names
    G2/M phase-specific HECT-type E3 ubiquitin transferase
    G2/M-phase specific E3 ubiquitin ligase
    PHD finger protein 7B
    NP_001295026.1
    NP_060239.2
    XP_011535227.1
    XP_011535228.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308097.2NP_001295026.1  G2/M phase-specific E3 ubiquitin-protein ligase isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks an exon in the 5' coding region, which results in use of a downstream start codon compared to variant 1. It encodes isoform 2, which has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AB037754, AK296872, AW963891, BC008436, BC040179, BM993069
      Consensus CDS
      CCDS76669.1
      UniProtKB/Swiss-Prot
      Q7L622
      UniProtKB/TrEMBL
      B4DL73, F5GX24, Q49AD9
      Related
      ENSP00000391068.2, ENST00000438909.6
      Conserved Domains (4) summary
      smart00119
      Location:365646
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd15496
      Location:186239
      PHD_PHF7_G2E3_like; PHD finger found in PHD finger protein 7 (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)
      cd15669
      Location:181
      ePHD_PHF7_G2E3_like; Extended PHD finger found in PHD finger protein 7 (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)
      cl00077
      Location:376646
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    2. NM_017769.5NP_060239.2  G2/M phase-specific E3 ubiquitin-protein ligase isoform 1

      See identical proteins and their annotated locations for NP_060239.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AB037754, AI432917, BM993069, DA491192
      Consensus CDS
      CCDS9638.1
      UniProtKB/Swiss-Prot
      Q7L622
      Related
      ENSP00000206595.6, ENST00000206595.11
      Conserved Domains (3) summary
      cd15496
      Location:232285
      PHD_PHF7_G2E3_like; PHD finger found in PHD finger protein 7 (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)
      cd15669
      Location:14127
      ePHD_PHF7_G2E3_like; Extended PHD finger found in PHD finger protein 7 (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)
      cl27008
      Location:411692
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

      Range
      30559136..30620064
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011536926.2XP_011535228.1  G2/M phase-specific E3 ubiquitin-protein ligase isoform X2

      Conserved Domains (4) summary
      smart00119
      Location:372653
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd15669
      Location:14127
      ePHD_PHF7_G2E3_like; Extended PHD finger found in PHD finger protein 7 (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)
      cl00077
      Location:383653
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cl22851
      Location:210246
      PHD_SF; PHD finger superfamily
    2. XM_011536925.2XP_011535227.1  G2/M phase-specific E3 ubiquitin-protein ligase isoform X1

      See identical proteins and their annotated locations for XP_011535227.1

      UniProtKB/Swiss-Prot
      Q7L622
      Related
      ENSP00000451653.1, ENST00000553504.5
      Conserved Domains (3) summary
      cd15496
      Location:232285
      PHD_PHF7_G2E3_like; PHD finger found in PHD finger protein 7 (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)
      cd15669
      Location:14127
      ePHD_PHF7_G2E3_like; Extended PHD finger found in PHD finger protein 7 (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)
      cl27008
      Location:411692
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    RNA

    1. XR_001750412.2 RNA Sequence

    2. XR_001750411.2 RNA Sequence

    3. XR_001750409.2 RNA Sequence

    4. XR_001750413.2 RNA Sequence

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