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    NUDT11 nudix hydrolase 11 [ Homo sapiens (human) ]

    Gene ID: 55190, updated on 12-Aug-2018

    Summary

    Official Symbol
    NUDT11provided by HGNC
    Official Full Name
    nudix hydrolase 11provided by HGNC
    Primary source
    HGNC:HGNC:18011
    See related
    Ensembl:ENSG00000196368 MIM:300528; Vega:OTTHUMG00000021531
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    APS1; ASP1; DIPP3b; DIPP3beta; hDIPP3beta
    Summary
    NUDT11 belongs to a subgroup of phosphohydrolases that preferentially attack diphosphoinositol polyphosphates (Hidaka et al., 2002 [PubMed 12105228]).[supplied by OMIM, Mar 2008]
    Expression
    Biased expression in testis (RPKM 29.1), brain (RPKM 16.8) and 4 other tissues See more
    Orthologs

    Genomic context

    See NUDT11 in Genome Data Viewer
    Location:
    Xp11.22
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) X NC_000023.11 (51490011..51496607, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (51232863..51239459, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373204 Neighboring gene centromere protein V pseudogene Neighboring gene chromosome X open reading frame 67 Neighboring gene long intergenic non-protein coding RNA 1496 Neighboring gene transfer RNA-Glu (CTC) 18-1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer.
    NHGRI GWA Catalog
    Multiple newly identified loci associated with prostate cancer susceptibility.
    NHGRI GWA Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of nudix (nucleoside diphosphate linked moiety X)-type motif 11 (NUDT11) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Inositol phosphate metabolism, organism-specific biosystem (from REACTOME)
      Inositol phosphate metabolism, organism-specific biosystemInositol phosphates (IPs) are molecules involves in signalling processes in eukaryotes. myo-Inositol consists of a six-carbon cyclic alcohol with an axial 2-hydroxy and five equatorial hydroxyls. M...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Synthesis of pyrophosphates in the cytosol, organism-specific biosystem (from REACTOME)
      Synthesis of pyrophosphates in the cytosol, organism-specific biosystemInositol phosphates such as IP4, IP5 and IP6 are converted to an even wider variety of IPs including the di- and triphospho inositol phosphates, also known as pyrophosphates (Irvine & Schell 2001, Al...

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ10628

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    bis(5'-adenosyl)-hexaphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    bis(5'-adenosyl)-pentaphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    diphosphoinositol-polyphosphate diphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    diphosphoinositol-polyphosphate diphosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    endopolyphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    inositol bisdiphosphate tetrakisphosphate diphosphatase activity TAS
    Traceable Author Statement
    more info
     
    inositol diphosphate pentakisphosphate diphosphatase activity TAS
    Traceable Author Statement
    more info
     
    inositol diphosphate tetrakisphosphate diphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    m7G(5')pppN diphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    adenosine 5'-(hexahydrogen pentaphosphate) catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    diadenosine hexaphosphate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    diadenosine pentaphosphate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    diphosphoinositol polyphosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    inositol phosphate metabolic process TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    intracellular IDA
    Inferred from Direct Assay
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    diphosphoinositol polyphosphate phosphohydrolase 3-beta
    Names
    DIPP-3-beta
    DIPP3-beta
    diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 3-beta
    diadenosine hexaphosphate hydrolase (AMP-forming)
    diphosphoinositol polyphosphate phosphohydrolase 3, beta
    hAps1
    nucleoside diphosphate-linked moiety X motif 11
    nudix (nucleoside diphosphate linked moiety X)-type motif 11
    nudix motif 11
    NP_060629.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018159.3NP_060629.2  diphosphoinositol polyphosphate phosphohydrolase 3-beta

      See identical proteins and their annotated locations for NP_060629.2

      Status: VALIDATED

      Source sequence(s)
      AL158055, BC009942, BX419815
      Consensus CDS
      CCDS43952.1
      UniProtKB/Swiss-Prot
      Q96G61
      Related
      ENSP00000365160.3, OTTHUMP00000023300, ENST00000375992.3, OTTHUMT00000056579
      Conserved Domains (1) summary
      cd04666
      Location:18137
      Nudix_Hydrolase_9; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p12 Primary Assembly

      Range
      51490011..51496607 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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