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    AURKAIP1 aurora kinase A interacting protein 1 [ Homo sapiens (human) ]

    Gene ID: 54998, updated on 5-Aug-2022

    Summary

    Official Symbol
    AURKAIP1provided by HGNC
    Official Full Name
    aurora kinase A interacting protein 1provided by HGNC
    Primary source
    HGNC:HGNC:24114
    See related
    Ensembl:ENSG00000175756 MIM:609183; AllianceGenome:HGNC:24114
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AIP; AKIP; MRP-S38
    Summary
    Acts upstream of or within positive regulation of proteolysis. Located in mitochondrion and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis (RPKM 40.0), kidney (RPKM 27.3) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See AURKAIP1 in Genome Data Viewer
    Location:
    1p36.33
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (1373736..1375207, complement)
    110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (804285..805756, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (1309116..1310587, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene matrix remodeling associated 8 Neighboring gene Sharpr-MPRA regulatory region 3626 Neighboring gene NADH:ubiquinone oxidoreductase subunit B4 pseudogene 8 Neighboring gene cyclin L2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ20608

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in mitochondrial inner membrane IC
    Inferred by Curator
    more info
    PubMed 
    located_in mitochondrial inner membrane TAS
    Traceable Author Statement
    more info
     
    part_of mitochondrial small ribosomal subunit IC
    Inferred by Curator
    more info
    PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    aurora kinase A-interacting protein
    Names
    28S ribosomal protein S38, mitochondrial
    AURKA-interacting protein
    aurora-A kinase interacting protein
    mitochondrial small ribosomal subunit protein mS38

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127229.2NP_001120701.1  aurora kinase A-interacting protein

      See identical proteins and their annotated locations for NP_001120701.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has a 5'UTR resulting from use of an alternate splice donor site.
      Source sequence(s)
      AK000615, AL139287, AW576100, BM781908, F31434
      Consensus CDS
      CCDS25.1
      UniProtKB/Swiss-Prot
      Q8TBD3, Q9NWT8
      UniProtKB/TrEMBL
      A0A024R0F0
      Related
      ENSP00000368130.3, ENST00000378853.3
      Conserved Domains (1) summary
      pfam08213
      Location:127157
      DUF1713; Mitochondrial domain of unknown function (DUF1713)
    2. NM_001127230.2NP_001120702.1  aurora kinase A-interacting protein

      See identical proteins and their annotated locations for NP_001120702.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has a 5'UTR resulting from use of an alternate splice donor site.
      Source sequence(s)
      AL139287, BC022808, BC062333, BE903314, BP198074, DN994953
      Consensus CDS
      CCDS25.1
      UniProtKB/Swiss-Prot
      Q8TBD3, Q9NWT8
      UniProtKB/TrEMBL
      A0A024R0F0
      Related
      ENSP00000319778.5, ENST00000321751.9
      Conserved Domains (1) summary
      pfam08213
      Location:127157
      DUF1713; Mitochondrial domain of unknown function (DUF1713)
    3. NM_017900.3NP_060370.1  aurora kinase A-interacting protein

      See identical proteins and their annotated locations for NP_060370.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) has a 5'UTR resulting from use of an alternate splice donor site.
      Source sequence(s)
      BC062333, BG764236
      Consensus CDS
      CCDS25.1
      UniProtKB/Swiss-Prot
      Q8TBD3, Q9NWT8
      UniProtKB/TrEMBL
      A0A024R0F0
      Related
      ENSP00000340656.5, ENST00000338338.10
      Conserved Domains (1) summary
      pfam08213
      Location:127157
      DUF1713; Mitochondrial domain of unknown function (DUF1713)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      1373736..1375207 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      804285..805756 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)