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    NCAPG2 non-SMC condensin II complex subunit G2 [ Homo sapiens (human) ]

    Gene ID: 54892, updated on 15-Jun-2019

    Summary

    Official Symbol
    NCAPG2provided by HGNC
    Official Full Name
    non-SMC condensin II complex subunit G2provided by HGNC
    Primary source
    HGNC:HGNC:21904
    See related
    Ensembl:ENSG00000146918 MIM:608532
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    3KS; MTB; CAPG2; LUZP5; CAP-G2; hCAP-G2
    Summary
    This gene encodes a protein that belongs to the Condensin2nSMC family of proteins. The encoded protein is a regulatory subunit of the condensin II complex which, along with the condensin I complex, plays a role in chromosome assembly and segregation during mitosis. A similar protein in mouse is required for early development of the embryo. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
    Expression
    Broad expression in testis (RPKM 7.7), bone marrow (RPKM 6.8) and 24 other tissues See more
    Orthologs

    Genomic context

    See NCAPG2 in Genome Data Viewer
    Location:
    7q36.3
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (158631169..158704831, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (158424002..158497520, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1022 Neighboring gene microRNA 5707 Neighboring gene THAP domain containing 5 pseudogene 1 Neighboring gene ribosomal protein L21 pseudogene 76 Neighboring gene extended synaptotagmin 2 Neighboring gene uncharacterized LOC105379752

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Cell Cycle, organism-specific biosystem (from REACTOME)
      Cell Cycle, organism-specific biosystem
      Cell Cycle
    • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
      Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
    • Condensation of Prophase Chromosomes, organism-specific biosystem (from REACTOME)
      Condensation of Prophase Chromosomes, organism-specific biosystemIn mitotic prophase, the action of the condensin II complex enables initial chromosome condensation.The condensin II complex subunit NCAPD3 binds monomethylated histone H4 (H4K20me1), thereby associa...
    • Endoderm Differentiation, organism-specific biosystem (from WikiPathways)
      Endoderm Differentiation, organism-specific biosystemModel depicting endoderm specification based on the literature and highly enriched gene expression profiles via comparison across dozens of independent induced and embryonic pluripotent stem cell lin...
    • M Phase, organism-specific biosystem (from REACTOME)
      M Phase, organism-specific biosystemMitosis, or the M phase, involves nuclear division and cytokinesis, where two identical daughter cells are produced. Mitosis involves prophase, prometaphase, metaphase, anaphase, and telophase. Fin...
    • Mesodermal Commitment Pathway, organism-specific biosystem (from WikiPathways)
      Mesodermal Commitment Pathway, organism-specific biosystemModel depicting mesodermal specification based on the literature and highly enriched gene expression profiles via comparison across dozens of independent induced and embryonic pluripotent stem cell l...
    • Mitotic Prophase, organism-specific biosystem (from REACTOME)
      Mitotic Prophase, organism-specific biosystemDuring prophase, the chromatin in the nucleus condenses, and the nucleolus disappears. Centrioles begin moving to the opposite poles or sides of the cell. Some of the fibers that extend from the cen...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Clone Names

    • FLJ20311

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    bHLH transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    methylated histone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    molecular function regulator IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    chromosome condensation IEA
    Inferred from Electronic Annotation
    more info
     
    erythrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    inner cell mass cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of erythrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    condensin complex IEA
    Inferred from Electronic Annotation
    more info
     
    membrane HDA PubMed 
    nuclear speck IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    condensin-2 complex subunit G2
    Names
    chromosome-associated protein G2
    leucine zipper protein 5
    more than blood homolog

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047159.1 RefSeqGene

      Range
      5001..78663
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001281932.2NP_001268861.1  condensin-2 complex subunit G2 isoform a

      See identical proteins and their annotated locations for NP_001268861.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein (isoform a).
      Source sequence(s)
      AC019084, AC093662, AK092008, DB069860, DW419642
      Consensus CDS
      CCDS43686.1
      UniProtKB/Swiss-Prot
      Q86XI2
      UniProtKB/TrEMBL
      B3KRQ2
      Related
      ENSP00000386569.1, ENST00000409423.5
      Conserved Domains (2) summary
      pfam12422
      Location:213361
      Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit
      sd00044
      Location:368405
      HEAT; HEAT repeat [structural motif]
    2. NM_001281933.2NP_001268862.1  condensin-2 complex subunit G2 isoform b

      See identical proteins and their annotated locations for NP_001268862.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate 3' terminal exon which results in a frameshift. The encoded isoform (b) has a distinct C-terminus and is longer than isoform a.
      Source sequence(s)
      AC019084, BX537845, DB069860
      Consensus CDS
      CCDS64816.1
      UniProtKB/Swiss-Prot
      Q86XI2
      Related
      ENSP00000387007.3, ENST00000409339.3
      Conserved Domains (2) summary
      pfam12422
      Location:213361
      Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit
      sd00044
      Location:368405
      HEAT; HEAT repeat [structural motif]
    3. NM_017760.7NP_060230.5  condensin-2 complex subunit G2 isoform a

      See identical proteins and their annotated locations for NP_060230.5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shortest transcript and encodes the shorter isoform (a). Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC093662, BC043404, DB069860, DW419642
      Consensus CDS
      CCDS43686.1
      UniProtKB/Swiss-Prot
      Q86XI2
      Related
      ENSP00000348657.3, ENST00000356309.7
      Conserved Domains (2) summary
      pfam12422
      Location:213361
      Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit
      sd00044
      Location:368405
      HEAT; HEAT repeat [structural motif]

    RNA

    1. NR_104054.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains three alternate exons and uses an alternate splice site in an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC093662, BC028618, DB069860, DW419642
      Related
      ENST00000432615.5

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

      Range
      158631169..158704831 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005249547.3XP_005249604.1  condensin-2 complex subunit G2 isoform X4

      See identical proteins and their annotated locations for XP_005249604.1

      Related
      ENSP00000408080.1, ENST00000441982.5
      Conserved Domains (2) summary
      pfam12422
      Location:213361
      Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit
      sd00044
      Location:368405
      HEAT; HEAT repeat [structural motif]
    2. XM_017012374.2XP_016867863.1  condensin-2 complex subunit G2 isoform X2

      Conserved Domains (2) summary
      pfam12422
      Location:213361
      Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit
      sd00044
      Location:368405
      HEAT; HEAT repeat [structural motif]
    3. XM_011516362.1XP_011514664.1  condensin-2 complex subunit G2 isoform X9

    4. XM_017012376.2XP_016867865.1  condensin-2 complex subunit G2 isoform X5

    5. XM_017012375.2XP_016867864.1  condensin-2 complex subunit G2 isoform X3

    6. XM_011516356.3XP_011514658.1  condensin-2 complex subunit G2 isoform X1

      See identical proteins and their annotated locations for XP_011514658.1

      UniProtKB/Swiss-Prot
      Q86XI2
      Conserved Domains (2) summary
      pfam12422
      Location:213361
      Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit
      sd00044
      Location:368405
      HEAT; HEAT repeat [structural motif]
    7. XM_011516357.2XP_011514659.1  condensin-2 complex subunit G2 isoform X1

      See identical proteins and their annotated locations for XP_011514659.1

      UniProtKB/Swiss-Prot
      Q86XI2
      Conserved Domains (2) summary
      pfam12422
      Location:213361
      Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit
      sd00044
      Location:368405
      HEAT; HEAT repeat [structural motif]
    8. XM_017012377.1XP_016867866.1  condensin-2 complex subunit G2 isoform X7

    9. XM_017012378.1XP_016867867.1  condensin-2 complex subunit G2 isoform X8

    10. XM_011516358.3XP_011514660.1  condensin-2 complex subunit G2 isoform X6

      Conserved Domains (2) summary
      pfam12422
      Location:213361
      Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit
      sd00044
      Location:368405
      HEAT; HEAT repeat [structural motif]
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