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    QPCTL glutaminyl-peptide cyclotransferase like [ Homo sapiens (human) ]

    Gene ID: 54814, updated on 5-Sep-2021

    Summary

    Official Symbol
    QPCTLprovided by HGNC
    Official Full Name
    glutaminyl-peptide cyclotransferase likeprovided by HGNC
    Primary source
    HGNC:HGNC:25952
    See related
    Ensembl:ENSG00000011478
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    gQC
    Expression
    Ubiquitous expression in thyroid (RPKM 3.4), prostate (RPKM 3.3) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See QPCTL in Genome Data Viewer
    Location:
    19q13.32
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (45692400..45703987)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (46195924..46207245)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene gastric inhibitory polypeptide receptor Neighboring gene microRNA 642a Neighboring gene microRNA 642b Neighboring gene small nuclear ribonucleoprotein D2 polypeptide Neighboring gene F-box protein 46 Neighboring gene meiosis initiator

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
    GeneReviews: Not available
    Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
    GeneReviews: Not available
    Meta-analysis identifies common variants associated with body mass index in east Asians.
    GeneReviews: Not available
    Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.
    GeneReviews: Not available

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with QPCTL; predicted interaction to be within the Golgi PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ20084

    General protein information

    Preferred Names
    glutaminyl-peptide cyclotransferase-like protein
    Names
    glutaminyl cyclase-like
    golgi-resident glutaminyl-peptide cyclotransferase
    isoQC
    NP_001156849.1
    NP_060129.2
    XP_011525350.1
    XP_016882389.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163377.2NP_001156849.1  glutaminyl-peptide cyclotransferase-like protein isoform 2

      See identical proteins and their annotated locations for NP_001156849.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AC007191, AK222636, BC011553, BP216511
      Consensus CDS
      CCDS54282.1
      UniProtKB/Swiss-Prot
      Q9NXS2
      Related
      ENSP00000387944.2, ENST00000366382.8
      Conserved Domains (1) summary
      cl14876
      Location:116285
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42
    2. NM_017659.4NP_060129.2  glutaminyl-peptide cyclotransferase-like protein isoform 1

      See identical proteins and their annotated locations for NP_060129.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC007191, AK000091, AK222636, BC011553, BP216511
      Consensus CDS
      CCDS12672.1
      UniProtKB/Swiss-Prot
      Q9NXS2
      Related
      ENSP00000012049.4, ENST00000012049.10
      Conserved Domains (1) summary
      cd03880
      Location:79379
      M28_QC_like; M28 Zn-Peptidase Glutaminyl Cyclase

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

      Range
      45692400..45703987
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011527048.3XP_011525350.1  glutaminyl-peptide cyclotransferase-like protein isoform X2

      Conserved Domains (1) summary
      cl14876
      Location:79191
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42
    2. XM_017026900.1XP_016882389.1  glutaminyl-peptide cyclotransferase-like protein isoform X1

    RNA

    1. XR_001753711.1 RNA Sequence

      Related
      ENST00000678862.1
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