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    SLCO1C1 solute carrier organic anion transporter family member 1C1 [ Homo sapiens (human) ]

    Gene ID: 53919, updated on 2-Oct-2018

    Summary

    Official Symbol
    SLCO1C1provided by HGNC
    Official Full Name
    solute carrier organic anion transporter family member 1C1provided by HGNC
    Primary source
    HGNC:HGNC:13819
    See related
    Ensembl:ENSG00000139155 MIM:613389; Vega:OTTHUMG00000168966
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OATP1; OATPF; OATP-F; OATP14; OATP1C1; OATPRP5; SLC21A14
    Summary
    This gene encodes a member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of thyroid hormones in brain tissues. This protein has particularly high affinity for the thyroid hormones thyroxine, tri-iodothyronine and reverse tri-iodothyronine. Polymorphisms in the gene encoding this protein may be associated with fatigue and depression in patients suffering from hyperthyroidism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]
    Expression
    Biased expression in brain (RPKM 4.0), fat (RPKM 0.5) and 3 other tissues See more
    Orthologs

    Genomic context

    See SLCO1C1 in Genome Data Viewer
    Location:
    12p12.2
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (20681800..20753386)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (20848289..20906320)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 3A Neighboring gene ubiquitin conjugating enzyme E2 L2 (pseudogene) Neighboring gene ubiquitin like with PHD and ring finger domains 1 pseudogene Neighboring gene solute carrier organic anion transporter family member 1B3 Neighboring gene solute carrier organic anion transporter family member 1B7 (putative)

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Hundreds of variants clustered in genomic loci and biological pathways affect human height.
    NHGRI GWA Catalog
    Investigation of single nucleotide polymorphisms and biological pathways associated with response to TNFα inhibitors in patients with rheumatoid arthritis.
    NHGRI GWA Catalog
    Many sequence variants affecting diversity of adult human height.
    NHGRI GWA Catalog

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    bile acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    sodium-independent organic anion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    thyroid hormone transmembrane transporter activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    bile acid and bile salt transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    sodium-independent organic anion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    sodium-independent organic anion transport TAS
    Traceable Author Statement
    more info
     
    thyroid hormone transport IEA
    Inferred from Electronic Annotation
    more info
     
    transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    solute carrier organic anion transporter family member 1C1
    Names
    OAT-RP-5
    OATP-14
    organic anion transporter F
    organic anion transporter polypeptide-related protein 5
    organic anion transporting polypeptide 14
    solute carrier family 21 (organic anion transporter), member 14
    solute carrier family 21 member 14
    thyroxine transporter

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145944.1NP_001139416.1  solute carrier organic anion transporter family member 1C1 isoform 4

      See identical proteins and their annotated locations for NP_001139416.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC092491, AF205076, AF260704, AK294333
      Consensus CDS
      CCDS53759.1
      UniProtKB/Swiss-Prot
      Q9NYB5
      Related
      ENSP00000444527.1, OTTHUMP00000239829, ENST00000545102.1, OTTHUMT00000401768
      Conserved Domains (1) summary
      pfam03137
      Location:69520
      OATP; Organic Anion Transporter Polypeptide (OATP) family
    2. NM_001145945.1NP_001139417.1  solute carrier organic anion transporter family member 1C1 isoform 3

      See identical proteins and their annotated locations for NP_001139417.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform 3) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC092491, AF260704, AK296236, DA345251
      Consensus CDS
      CCDS53758.1
      UniProtKB/Swiss-Prot
      Q9NYB5
      Related
      ENSP00000438665.1, OTTHUMP00000239827, ENST00000540354.5, OTTHUMT00000401764
      Conserved Domains (2) summary
      cd01330
      Location:423476
      KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
      pfam03137
      Location:44589
      OATP; Organic Anion Transporter Polypeptide (OATP) family
    3. NM_001145946.1NP_001139418.1  solute carrier organic anion transporter family member 1C1 isoform 1

      See identical proteins and their annotated locations for NP_001139418.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC092491, AF260704, AK303713, DA345251
      Consensus CDS
      CCDS53757.1
      UniProtKB/Swiss-Prot
      Q9NYB5
      Related
      ENSP00000444149.1, OTTHUMP00000275001, ENST00000545604.5, OTTHUMT00000474423
      Conserved Domains (3) summary
      cd06174
      Location:48446
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      cd01330
      Location:472525
      KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
      pfam03137
      Location:44638
      OATP; Organic Anion Transporter Polypeptide (OATP) family
    4. NM_017435.4NP_059131.1  solute carrier organic anion transporter family member 1C1 isoform 2

      See identical proteins and their annotated locations for NP_059131.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate splice site in the 3' coding region that results in a frameshift, compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC092491, AF205076, AF260704
      Consensus CDS
      CCDS8683.1
      UniProtKB/Swiss-Prot
      Q9NYB5
      Related
      ENSP00000266509.2, OTTHUMP00000239828, ENST00000266509.6, OTTHUMT00000401765
      Conserved Domains (3) summary
      cd06174
      Location:48299
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      cd01330
      Location:472525
      KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
      pfam03137
      Location:44638
      OATP; Organic Anion Transporter Polypeptide (OATP) family

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

      Range
      20681800..20753386
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017019489.2XP_016874978.1  solute carrier organic anion transporter family member 1C1 isoform X7

      Conserved Domains (3) summary
      cd06174
      Location:2261
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      cd01330
      Location:287340
      KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
      pfam03137
      Location:2453
      OATP; Organic Anion Transporter Polypeptide (OATP) family
    2. XM_017019490.2XP_016874979.1  solute carrier organic anion transporter family member 1C1 isoform X7

      Conserved Domains (3) summary
      cd06174
      Location:2261
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      cd01330
      Location:287340
      KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
      pfam03137
      Location:2453
      OATP; Organic Anion Transporter Polypeptide (OATP) family
    3. XM_017019486.2XP_016874975.1  solute carrier organic anion transporter family member 1C1 isoform X5

    4. XM_011520711.3XP_011519013.1  solute carrier organic anion transporter family member 1C1 isoform X6

      Conserved Domains (3) summary
      cd06174
      Location:16280
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      cd01330
      Location:306359
      KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
      pfam03137
      Location:21472
      OATP; Organic Anion Transporter Polypeptide (OATP) family
    5. XM_005253396.3XP_005253453.1  solute carrier organic anion transporter family member 1C1 isoform X4

      See identical proteins and their annotated locations for XP_005253453.1

      UniProtKB/Swiss-Prot
      Q9NYB5
      Conserved Domains (1) summary
      pfam03137
      Location:69520
      OATP; Organic Anion Transporter Polypeptide (OATP) family
    6. XM_017019487.2XP_016874976.1  solute carrier organic anion transporter family member 1C1 isoform X5

    7. XM_005253394.3XP_005253451.1  solute carrier organic anion transporter family member 1C1 isoform X2

      See identical proteins and their annotated locations for XP_005253451.1

      UniProtKB/Swiss-Prot
      Q9NYB5
      Conserved Domains (3) summary
      cd06174
      Location:48299
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      cd01330
      Location:472525
      KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
      pfam03137
      Location:44638
      OATP; Organic Anion Transporter Polypeptide (OATP) family
    8. XM_011520703.3XP_011519005.1  solute carrier organic anion transporter family member 1C1 isoform X1

      Conserved Domains (3) summary
      cd06174
      Location:48446
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      cd01330
      Location:472525
      KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
      pfam03137
      Location:44637
      OATP; Organic Anion Transporter Polypeptide (OATP) family
    9. XM_011520704.3XP_011519006.1  solute carrier organic anion transporter family member 1C1 isoform X3

      Conserved Domains (3) summary
      cd06174
      Location:48299
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      cd01330
      Location:472525
      KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
      pfam03137
      Location:44637
      OATP; Organic Anion Transporter Polypeptide (OATP) family
    10. XM_024449025.1XP_024304793.1  solute carrier organic anion transporter family member 1C1 isoform X4

      Conserved Domains (1) summary
      pfam03137
      Location:69520
      OATP; Organic Anion Transporter Polypeptide (OATP) family
    11. XM_024449024.1XP_024304792.1  solute carrier organic anion transporter family member 1C1 isoform X4

      Conserved Domains (1) summary
      pfam03137
      Location:69520
      OATP; Organic Anion Transporter Polypeptide (OATP) family

    RNA

    1. XR_001748771.2 RNA Sequence

    2. XR_001748768.2 RNA Sequence

    3. XR_001748769.2 RNA Sequence

    4. XR_001748770.2 RNA Sequence

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