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    LAMP2 lysosomal associated membrane protein 2 [ Bos taurus (cattle) ]

    Gene ID: 529148, updated on 27-Aug-2018

    Summary

    Official Symbol
    LAMP2provided by VGNC
    Official Full Name
    lysosomal associated membrane protein 2provided by VGNC
    Primary source
    VGNC:VGNC:30776
    See related
    BGD:BT12099; Ensembl:ENSBTAG00000007399
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs

    Genomic context

    See LAMP2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current ARS-UCD1.2 (GCF_002263795.1) X NC_037357.1 (4985631..5023603, complement)
    105 previous assembly Bos_taurus_UMD_3.1.1 (GCF_000003055.6) X AC_000187.1 (4846757..4884066)

    Chromosome X - NC_037357.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112445125 Neighboring gene ATPase Na+/K+ transporting family member beta 4 Neighboring gene putative testis-expressed protein 13C Neighboring gene uncharacterized LOC112445118 Neighboring gene cullin 4B

    Genomic regions, transcripts, and products

    Pathways from BioSystems

    • Autophagy - animal, organism-specific biosystem (from KEGG)
      Autophagy - animal, organism-specific biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
    • Autophagy - animal, conserved biosystem (from KEGG)
      Autophagy - animal, conserved biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Lysosome, organism-specific biosystem (from KEGG)
      Lysosome, organism-specific biosystemLysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than...
    • Lysosome, conserved biosystem (from KEGG)
      Lysosome, conserved biosystemLysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than...
    • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
      Neutrophil degranulation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Phagosome, organism-specific biosystem (from KEGG)
      Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Phagosome, conserved biosystem (from KEGG)
      Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
      Platelet activation, signaling and aggregation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Platelet degranulation, organism-specific biosystem (from REACTOME)
      Platelet degranulation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Response to elevated platelet cytosolic Ca2+, organism-specific biosystem (from REACTOME)
      Response to elevated platelet cytosolic Ca2+, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Senescence and Autophagy in Cancer, organism-specific biosystem (from WikiPathways)
      Senescence and Autophagy in Cancer, organism-specific biosystemSenescense and Autophagy Pathways in Cancer
    • Tuberculosis, organism-specific biosystem (from KEGG)
      Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Tuberculosis, conserved biosystem (from KEGG)
      Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...

    General gene information

    Markers

    Homology

    Clone Names

    • MGC127297

    General protein information

    Preferred Names
    lysosome-associated membrane glycoprotein 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034570.2NP_001029742.1  lysosome-associated membrane glycoprotein 2 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001029742.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes an alternate terminal exon and encodes a shorter protein isoform (2).
      Source sequence(s)
      BC102819, DT813358, DT826059
      UniProtKB/TrEMBL
      Q3SZJ7
      Related
      ENSBTAP00000046293.2, ENSBTAT00000049397.2
      Conserved Domains (2) summary
      cd12087
      Location:371400
      TM_EGFR-like; Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases
      pfam01299
      Location:114407
      Lamp; Lysosome-associated membrane glycoprotein (Lamp)
    2. NM_001113244.1NP_001106715.1  lysosome-associated membrane glycoprotein 2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001106715.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) includes an alternate terminal exon and encodes a longer protein isoform (1).
      Source sequence(s)
      CO875688, DT813358, DV891215
      UniProtKB/TrEMBL
      G3MXJ5
      Related
      ENSBTAP00000054262.1, ENSBTAT00000065411.1
      Conserved Domains (1) summary
      pfam01299
      Location:114407
      Lamp; Lysosome-associated membrane glycoprotein (Lamp)

    RefSeqs of Annotated Genomes: Bos taurus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD1.2 Primary Assembly

    Genomic

    1. NC_037357.1 Reference ARS-UCD1.2 Primary Assembly

      Range
      4985631..5023603 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005227463.4XP_005227520.1  lysosome-associated membrane glycoprotein 2 isoform X1

      Conserved Domains (1) summary
      pfam01299
      Location:159453
      Lamp; Lysosome-associated membrane glycoprotein (Lamp)
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