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    P2RX1 purinergic receptor P2X 1 [ Homo sapiens (human) ]

    Gene ID: 5023, updated on 8-Jul-2021

    Summary

    Official Symbol
    P2RX1provided by HGNC
    Official Full Name
    purinergic receptor P2X 1provided by HGNC
    Primary source
    HGNC:HGNC:8533
    See related
    Ensembl:ENSG00000108405 MIM:600845
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P2X1
    Summary
    The protein encoded by this gene belongs to the P2X family of G-protein-coupled receptors. These proteins can form homo-and heterotimers and function as ATP-gated ion channels and mediate rapid and selective permeability to cations. This protein is primarily localized to smooth muscle where binds ATP and mediates synaptic transmission between neurons and from neurons to smooth muscle and may being responsible for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. This protein may also be involved in promoting apoptosis. [provided by RefSeq, Jun 2013]
    Expression
    Broad expression in bone marrow (RPKM 20.3), urinary bladder (RPKM 20.1) and 15 other tissues See more
    Orthologs
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    Genomic context

    See P2RX1 in Genome Data Viewer
    Location:
    17p13.2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (3896591..3916506, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (3799886..3819759, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene integrin subunit alpha E Neighboring gene nuclear cap binding subunit 3 Neighboring gene calcium/calmodulin dependent protein kinase kinase 1 Neighboring gene ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 Neighboring gene long intergenic non-protein coding RNA 1975

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Infection of CD4+ T cells with HIV-1 in the presence of inhibitors of P2X receptors greatly inhibits HIV-1 infection via both cell-free and cell-to-cell contact in a dose-dependent manner, suggesting P2X receptors interact with gp120/gp41 in viral entry PubMed
    env Interaction of the HIV-1 gp120 with macrophages triggers an increase in ATP release that stimulates purinergic receptor P2X(1), P2X(7), and P2Y(1) proteins and facilitates HIV entry and subsequent stages of viral replication PubMed
    Envelope transmembrane glycoprotein gp41 env Infection of CD4+ T cells with HIV-1 in the presence of inhibitors of P2X receptors greatly inhibits HIV-1 infection via both cell-free and cell-to-cell contact in a dose-dependent manner, suggesting P2X receptors interact with gp120/gp41 in viral entry PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cation channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables extracellularly ATP-gated cation channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables purinergic nucleotide receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cation transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ceramide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in excitatory postsynaptic potential IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in insemination IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neuronal action potential IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in platelet activation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of calcium ion import across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in purinergic nucleotide receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of blood pressure IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of presynaptic cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of synaptic vesicle exocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of vascular associated smooth muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to ATP IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in serotonin secretion by platelet IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in synaptic transmission, glutamatergic IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in integral component of nuclear inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in integral component of postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of presynaptic active zone membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane raft IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in secretory granule membrane TAS
    Traceable Author Statement
    more info
     
    located_in specific granule membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    P2X purinoceptor 1
    Names
    ATP receptor
    P2X receptor, subunit 1
    P2X1 receptor
    purinergic receptor P2X, ligand gated ion channel, 1
    purinergic receptor P2X1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012109.1 RefSeqGene

      Range
      5202..25075
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_002558.4NP_002549.1  P2X purinoceptor 1

      See identical proteins and their annotated locations for NP_002549.1

      Status: REVIEWED

      Source sequence(s)
      AC005940, BC044657, BX644575
      Consensus CDS
      CCDS11040.1
      UniProtKB/Swiss-Prot
      P51575
      Related
      ENSP00000225538.3, ENST00000225538.4
      Conserved Domains (1) summary
      TIGR00863
      Location:1368
      P2X; cation transporter protein

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

      Range
      3896591..3916506 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006721529.2XP_006721592.1  P2X purinoceptor 1 isoform X5

      Conserved Domains (1) summary
      cl02993
      Location:1351
      P2X_receptor; ATP P2X receptor
    2. XM_011523897.2XP_011522199.1  P2X purinoceptor 1 isoform X2

      Conserved Domains (1) summary
      TIGR00863
      Location:1388
      P2X; cation transporter protein
    3. XM_011523898.3XP_011522200.1  P2X purinoceptor 1 isoform X3

      Conserved Domains (1) summary
      pfam00864
      Location:59389
      P2X_receptor; ATP P2X receptor
    4. XM_011523899.3XP_011522201.1  P2X purinoceptor 1 isoform X4

      Conserved Domains (1) summary
      pfam00864
      Location:59386
      P2X_receptor; ATP P2X receptor
    5. XM_011523896.3XP_011522198.1  P2X purinoceptor 1 isoform X1

      See identical proteins and their annotated locations for XP_011522198.1

      Conserved Domains (1) summary
      pfam00864
      Location:59406
      P2X_receptor; ATP P2X receptor
    6. XM_011523900.3XP_011522202.1  P2X purinoceptor 1 isoform X6

      Conserved Domains (1) summary
      cl02993
      Location:59187
      P2X_receptor; ATP P2X receptor

    RNA

    1. XR_934030.3 RNA Sequence

    2. XR_934029.3 RNA Sequence

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