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    OAS2 2'-5'-oligoadenylate synthetase 2 [ Homo sapiens (human) ]

    Gene ID: 4939, updated on 21-Jul-2021

    Summary

    Official Symbol
    OAS2provided by HGNC
    Official Full Name
    2'-5'-oligoadenylate synthetase 2provided by HGNC
    Primary source
    HGNC:HGNC:8087
    See related
    Ensembl:ENSG00000111335 MIM:603350
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
    Annotation information
    Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
    Expression
    Broad expression in spleen (RPKM 18.2), lymph node (RPKM 14.1) and 22 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See OAS2 in Genome Data Viewer
    Location:
    12q24.13
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (112978466..113011723)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (113416324..113449528)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene 2'-5'-oligoadenylate synthetase 1 Neighboring gene 2'-5'-oligoadenylate synthetase 3 Neighboring gene inner mitochondrial membrane peptidase subunit 1 pseudogene 2 Neighboring gene ribosomal protein S15a pseudogene 32

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
    GeneReviews: Not available
    Preliminary evidence of genetic determinants of adiponectin response to fenofibrate in the Genetics of Lipid Lowering Drugs and Diet Network.
    GeneReviews: Not available

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 and the viral protein Tat modulate the expression of 2',5'-oligoadenylate synthetase 2, 69/71kDa (OAS2) in immature dendritic cells and monocyte-derived macrophages PubMed
    tat HIV-1 Tat interacts with interferon-inducible enzymes 2-5A synthetase and dsRNA-dependent protein kinase to influence the rate of translation and protein synthesis in vitro PubMed
    Vpr vpr HIV-1 Vpr upregulates the gene expression of OAS2 in human monocyte-derived dendritic cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC78578

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 2'-5'-oligoadenylate synthetase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables 2'-5'-oligoadenylate synthetase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables 2'-5'-oligoadenylate synthetase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables ATP binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables double-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables double-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables double-stranded RNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in RNA catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in defense response to virus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in defense response to virus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in interleukin-27-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of viral genome replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in nucleobase-containing compound metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of interferon-beta production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of tumor necrosis factor production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of lactation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of ribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in response to virus TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in type I interferon signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in intracellular membrane-bounded organelle TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in membrane HDA PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    2'-5'-oligoadenylate synthase 2
    Names
    (2'-5')oligo(A) synthetase 2
    2'-5'-oligoadenylate synthetase 2, 69/71kDa
    2-5A synthase 2
    p69 OAS / p71 OAS
    NP_001027903.1
    NP_002526.2
    NP_058197.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029692.1 RefSeqGene

      Range
      5051..38255
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001032731.2NP_001027903.1  2'-5'-oligoadenylate synthase 2 isoform 3

      See identical proteins and their annotated locations for NP_001027903.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an additional segment in the 5' coding region, compared to variant 1, which leads to a premature stop codon. It encodes isoform 3, which has a shorter, distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC004551, BC069052, BE885222
      Consensus CDS
      CCDS44982.1
      UniProtKB/Swiss-Prot
      P29728
      UniProtKB/TrEMBL
      Q7Z6D0
      Related
      ENSP00000411763.2, ENST00000449768.2
      Conserved Domains (1) summary
      cd05400
      Location:31150
      NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
    2. NM_002535.3NP_002526.2  2'-5'-oligoadenylate synthase 2 isoform 2

      See identical proteins and their annotated locations for NP_002526.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an additional segment in the 3' coding region, compared to variant 1, which leads to a premature stop codon. It encodes isoform 2, also known as p69, which has a shorter, distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC004551, BC049215, BE885222, BQ213828
      Consensus CDS
      CCDS41839.1
      UniProtKB/Swiss-Prot
      P29728
      Related
      ENSP00000376362.3, ENST00000392583.7
      Conserved Domains (2) summary
      cd05400
      Location:362545
      NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
      pfam10421
      Location:498685
      OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
    3. NM_016817.3NP_058197.2  2'-5'-oligoadenylate synthase 2 isoform 1

      See identical proteins and their annotated locations for NP_058197.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1), which is also known as the p71 isoform.
      Source sequence(s)
      AC004551, BC049215, BE885222, BQ213828
      Consensus CDS
      CCDS31906.1
      UniProtKB/Swiss-Prot
      P29728
      Related
      ENSP00000342278.4, ENST00000342315.8
      Conserved Domains (2) summary
      cd05400
      Location:362545
      NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
      pfam10421
      Location:496683
      OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

      Range
      112978466..113011723
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_001748725.2 RNA Sequence

      Related
      ENST00000680138.1
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