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    TSPAN11 tetraspanin 11 [ Homo sapiens (human) ]

    Gene ID: 441631, updated on 17-Sep-2024

    Summary

    Official Symbol
    TSPAN11provided by HGNC
    Official Full Name
    tetraspanin 11provided by HGNC
    Primary source
    HGNC:HGNC:30795
    See related
    Ensembl:ENSG00000110900 AllianceGenome:HGNC:30795
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    VSSW1971
    Summary
    Predicted to be involved in cell migration. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in brain (RPKM 4.2), gall bladder (RPKM 3.5) and 22 other tissues See more
    Orthologs
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    Genomic context

    See TSPAN11 in Genome Data Viewer
    Location:
    12p11.21
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (30926748..31016502)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (30801368..30891025)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (31079682..31149534)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984476 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:31027609-31028110 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:31062613-31063113 Neighboring gene uncharacterized LOC124902911 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_28199 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:31117766-31118266 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:31130578-31131412 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:31133507-31134008 Neighboring gene TSPAN11 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:31134009-31134508 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6161 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:31140539-31141040 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:31141041-31141540 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:31165500-31165701 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:31181720-31181949 Neighboring gene DDX11 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 7044 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:31226445-31226976 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:31227509-31228038 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:31232984-31233540 Neighboring gene DEAD/H-box helicase 11 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:31256969-31257468

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    tetraspanin-11
    Names
    tspan-11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080509.3NP_001073978.1  tetraspanin-11 isoform 1

      See identical proteins and their annotated locations for NP_001073978.1

      Status: VALIDATED

      Source sequence(s)
      AC008013, AC008150
      Consensus CDS
      CCDS31765.1
      UniProtKB/Swiss-Prot
      A1L157, A1L158, B2RUX6
      UniProtKB/TrEMBL
      B4DF63
      Related
      ENSP00000261177.9, ENST00000261177.10
      Conserved Domains (2) summary
      cd03155
      Location:112220
      CD151_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
      pfam00335
      Location:16244
      Tetraspannin; Tetraspanin family
    2. NM_001370301.1NP_001357230.1  tetraspanin-11 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC008013, AC008150
      UniProtKB/TrEMBL
      B4DV40
      Conserved Domains (2) summary
      cd03155
      Location:102210
      CD151_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
      pfam00335
      Location:19234
      Tetraspannin; Tetraspanin family
    3. NM_001370302.1NP_001357231.1  tetraspanin-11 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC008013, AC008150
      Consensus CDS
      CCDS31765.1
      UniProtKB/Swiss-Prot
      A1L157, A1L158, B2RUX6
      UniProtKB/TrEMBL
      B4DF63
      Related
      ENSP00000437403.1, ENST00000546076.6
      Conserved Domains (2) summary
      cd03155
      Location:112220
      CD151_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
      pfam00335
      Location:16244
      Tetraspannin; Tetraspanin family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      30926748..31016502
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011520679.3XP_011518981.1  tetraspanin-11 isoform X1

      Conserved Domains (3) summary
      PHA03242
      Location:50118
      PHA03242; envelope glycoprotein M; Provisional
      cd03155
      Location:112220
      CD151_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
      pfam00335
      Location:16235
      Tetraspannin; Tetraspanin family

    RNA

    1. XR_001748709.2 RNA Sequence

    2. XR_001748710.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      30801368..30891025
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054372080.1XP_054228055.1  tetraspanin-11 isoform X1

    RNA

    1. XR_008488588.1 RNA Sequence

    2. XR_008488589.1 RNA Sequence