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    S surface glycoprotein [ Severe acute respiratory syndrome coronavirus 2 ]

    Gene ID: 43740568, updated on 22-Nov-2021

    Summary

    Gene symbol
    S
    Gene description
    surface glycoprotein
    Locus tag
    GU280_gp02
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Severe acute respiratory syndrome coronavirus 2 (isolate: Wuhan-Hu-1, nat-host: Homo sapiens)
    Lineage
    Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes; Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae; Betacoronavirus; Sarbecovirus
    Also known as
    spike glycoprotein
    Summary
    Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped, positive-sense, single-stranded RNA virus that causes coronavirus disease 2019 (COVID-19). Virus particles include the RNA genetic material and structural proteins needed for invasion of host cells. Once inside the cell the infecting RNA is used to encode structural proteins that make up virus particles, nonstructural proteins that direct virus assembly, transcription, replication and host control and accessory proteins whose function has not been determined.~ The structural proteins of SARS-CoV-2 include the envelope protein (E), spike or surface glycoprotein (S), membrane protein (M) and the nucleocapsid protein (N). The spike glycoprotein is found on the outside of the virus particle and gives coronavirus viruses their crown-like appearance. This glycoprotein mediates attachment of the virus particle and entry into the host cell. S protein is an important target for vaccine development, antibody therapies and diagnostic antigen-based tests.
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    Genomic context

    Sequence:
    NC_045512.2 (21563..25384)

    NC_045512.2Genomic Context describing neighboring genes Neighboring gene ORF1a polyprotein;ORF1ab polyprotein Neighboring gene ORF3a protein Neighboring gene envelope protein

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    surface glycoprotein
    YP_009724390.1
    • structural protein; spike protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_045512.2 Reference assembly

      Range
      21563..25384
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_009724390.1 surface glycoprotein [Severe acute respiratory syndrome coronavirus 2]

      Status: PROVISIONAL

      Conserved Domains (4) summary
      cd21480
      Location:319541
      SARS-CoV-2_Spike_S1_RBD; receptor-binding domain of the S1 subunit of severe acute respiratory syndrome coronavirus 2 Spike (S) protein
      cd21624
      Location:13304
      SARS-CoV-like_Spike_S1_NTD; N-terminal domain of the S1 subunit of the Spike (S) protein from Severe acute respiratory syndrome coronavirus and related betacoronaviruses in the B lineage
      pfam19214
      Location:12331273
      CoV_S2_C; Coronavirus spike glycoprotein S2, intravirion
      cd22378
      Location:5431208
      SARS-CoV-like_Spike_SD1-2_S1-S2_S2; SD-1 and SD-2 subdomains, the S1/S2 cleavage region, and the S2 fusion subunit of the spike (S) glycoprotein from SARS-CoV-2 (COVID-19) and related betacoronaviruses in the B lineage
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