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    BLA major histocompatibility complex class II alpha chain BLA [ Gallus gallus (chicken) ]

    Gene ID: 430189, updated on 20-Jun-2018

    Summary

    Official Symbol
    BLAprovided by CGNC
    Official Full Name
    major histocompatibility complex class II alpha chain BLAprovided by CGNC
    Primary source
    CGNC:53878
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    B-LA; HLA-DRA
    Annotation information
    Annotation category: partial on reference assembly

    Genomic context

    See BLA in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    104 current GRCg6a (GCF_000002315.5) 23 NC_006110.5 (5959349..5959606, complement)
    103 previous assembly Gallus_gallus-5.0 (GCF_000002315.4) Unplaced Scaffold NT_466905.1 (2725..2982, complement)

    Chromosome 23 - NC_006110.5Genomic Context describing neighboring genes Neighboring gene NIPA like domain containing 3 Neighboring gene RCAN family member 3 Neighboring gene probable RNA-binding protein 23 Neighboring gene semaphorin-4A-like Neighboring gene solute carrier family 25 member 44

    Genomic regions, transcripts, and products

    Pathways from BioSystems

    • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
      Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
      Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Herpes simplex infection, organism-specific biosystem (from KEGG)
      Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Herpes simplex infection, conserved biosystem (from KEGG)
      Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Influenza A, organism-specific biosystem (from KEGG)
      Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Influenza A, conserved biosystem (from KEGG)
      Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Intestinal immune network for IgA production, organism-specific biosystem (from KEGG)
      Intestinal immune network for IgA production, organism-specific biosystemThe intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunity is its ability to generate great amounts of noninflammatory immunoglobulin A (IgA) antibodies tha...
    • Intestinal immune network for IgA production, conserved biosystem (from KEGG)
      Intestinal immune network for IgA production, conserved biosystemThe intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunity is its ability to generate great amounts of noninflammatory immunoglobulin A (IgA) antibodies tha...
    • Phagosome, organism-specific biosystem (from KEGG)
      Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Phagosome, conserved biosystem (from KEGG)
      Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...

    General gene information

    Homology

    General protein information

    Preferred Names
    B-LA
    Names
    MHC class II alpha chain
    MHC class II antigen alpha chain
    major histocompatibility complex class II alpha chain BLA, (similar to HLA class II, D alpha chain)
    major histocompatibility complex, class II, DR alpha

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001245061.1NP_001231990.1  B-LA precursor

      See identical proteins and their annotated locations for NP_001231990.1

      Status: PROVISIONAL

      Source sequence(s)
      DQ207939
      UniProtKB/TrEMBL
      Q3HM56
      Conserved Domains (3) summary
      cd05767
      Location:112205
      IgC_MHC_II_alpha; Class II major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      pfam00993
      Location:27107
      MHC_II_alpha; Class II histocompatibility antigen, alpha domain
      pfam16196
      Location:204253
      C1-set_C; C1-set C-terminal domain

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCg6a Primary Assembly

    Genomic

    1. NC_006110.5 Reference GRCg6a Primary Assembly

      Range
      5959349..5959606 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001001762.1: Suppressed sequence

      Description
      NM_001001762.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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