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    nsr novel spermatogenesis regulator [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37577, updated on 28-Oct-2024

    Summary

    Official Symbol
    nsrprovided by FlyBase
    Official Full Name
    novel spermatogenesis regulatorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034740
    Locus tag
    Dmel_CG3875
    See related
    AllianceGenome:FB:FBgn0034740
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg3875; CG3875; Dmel\CG3875
    Summary
    Predicted to enable mRNA binding activity. Involved in post-transcriptional regulation of gene expression; sperm axoneme assembly; and sperm individualization. Located in nuclear speck. Orthologous to human KHDRBS2 (KH RNA binding domain containing, signal transduction associated 2) and KHDRBS3 (KH RNA binding domain containing, signal transduction associated 3). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
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    Genomic context

    See nsr in Genome Data Viewer
    Location:
    58F4-58F4; 2-100 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (22650556..22653595)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18538061..18541100)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Cytochrome P450 6d2 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45268 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding ISM
    Inferred from Sequence Model
    more info
    PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in post-transcriptional regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sperm axoneme assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sperm individualization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    putative spermatogenesis regulator
    Names
    CG3875-PA
    CG3875-PB
    nsr-PA
    nsr-PB

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      22650556..22653595
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299807.1NP_001286736.1  putative spermatogenesis regulator, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286736.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8E737, Q9W224
      Conserved Domains (1) summary
      cd02395
      Location:87206
      SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...
    2. NM_137838.3NP_611682.1  putative spermatogenesis regulator, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611682.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8E737, Q9W224
      Related
      FBpp0071772
      Conserved Domains (1) summary
      cd02395
      Location:87206
      SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...