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    qkr54B quaking related 54B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36966, updated on 2-Nov-2024

    Summary

    Official Symbol
    qkr54Bprovided by FlyBase
    Official Full Name
    quaking related 54Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0022987
    Locus tag
    Dmel_CG4816
    See related
    AllianceGenome:FB:FBgn0022987
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4816; Dmel\CG4816; p62GAP; Qkr54B; QKR54B; qrk54B; Qrk54B; SAM; Sam50; SAM50
    Summary
    Enables RNA binding activity. Predicted to be involved in regulation of alternative mRNA splicing, via spliceosome. Located in cytoplasm. Is expressed in organism and ovary. Orthologous to several human genes including KHDRBS2 (KH RNA binding domain containing, signal transduction associated 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
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    Genomic context

    See qkr54B in Genome Data Viewer
    Location:
    54B16-54B16; 2-82 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17469624..17475129)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13357129..13362634)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Testin Neighboring gene insensible Neighboring gene uncharacterized protein Neighboring gene veil

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in regulation of alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    quaking related 54B
    Names
    CG4816-PA
    CG4816-PB
    CG4816-PD
    CG4816-PE
    qkr54B-PA
    qkr54B-PB
    qkr54B-PD
    qkr54B-PE

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      17469624..17475129
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274121.1NP_001261050.1  quaking related 54B, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261050.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFT9
      Conserved Domains (2) summary
      cd02395
      Location:122237
      SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...
      pfam16274
      Location:68117
      Qua1; Qua1 domain
    2. NM_166231.3NP_725680.2  quaking related 54B, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725680.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZAT7, O44433, Q7KNS5
      Conserved Domains (2) summary
      cd02395
      Location:122237
      SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...
      pfam16274
      Location:68117
      Qua1; Qua1 domain
    3. NM_166230.3NP_725679.1  quaking related 54B, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725679.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZAT7, O44433, Q7KNS5
      Related
      FBpp0086079
      Conserved Domains (2) summary
      cd02395
      Location:122237
      SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...
      pfam16274
      Location:68117
      Qua1; Qua1 domain
    4. NM_079048.4NP_523772.1  quaking related 54B, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523772.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZAT7, O44433, Q7KNS5
      Related
      FBpp0086081
      Conserved Domains (2) summary
      cd02395
      Location:122237
      SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...
      pfam16274
      Location:68117
      Qua1; Qua1 domain